Core body temperature

Where it participates (unsigned role)

1. Administration of dihydrocapsaicin to rats resulted in a dose-dependent hypothermia over 0.5 to 10 mg/kg subcutaneously, and dihydrocapsaicin was approximately 65% more effective in producing hypothermia than capsaicin.

   Dihydrocapsaicin → Capsaicin source_derived_draftungraded
   Experimental context and source evidence

   evidence_span

   {"source_cache": "artifacts/dihydrocapsaicin-research/6184240.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dbeb69d90d490215b73d7a6f70fab0043e16cfdc8659c0daa4fda2cc0a7f6eaa", "start_char": 0, "end_char": 897, "text_sha256": "dbeb69d90d490215b73d7a6f70fab0043e16cfdc8659c0daa4fda2cc0a7f6eaa"}

   experimental_model

   Dose-ranging subcutaneous administration in rats with repeated dosing, antinociception testing and regional substance P measurement

   exposure

   Dihydrocapsaicin 0.5 to 10 mg/kg subcutaneously, single and repeated, against capsaicin

   limitations

   The founding comparison. It is a 1982 study and the antinociception endpoints are behavioural, but it is the only record here that puts a number on how the two compounds differ on temperature.

   nutrient_topic

   Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin

   organism

   Rat

   plain_language

   For lowering body temperature, dihydrocapsaicin is roughly two thirds more powerful than capsaicin.

   primary_references

   [dhc-p6184240] Dihydrocapsaicin-induced hypothermia and substance P depletion. (1982). https://pubmed.ncbi.nlm.nih.gov/6184240/ DOI: 10.1016/0014-2999(82)90263-1

   tissue_or_cell_type

   Whole body, dorsal root ganglia and spinal cord

   Dihydrocapsaicin: the second capsaicinoid, the hypothermia it is used to induce, what the gut and liver do to it, and what it does without TRPV1 (2026-09-21) · lines 179–190

   AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Dose-ranging subcutaneous administration in rats with repeated dosing, antinociception testing and regional substance P measurement · source_derived_draft · unverified_draft

   ### dhc-dhc-more-hypothermic Administration of dihydrocapsaicin to rats resulted in a dose-dependent hypothermia over 0.5 to 10 mg/kg subcutaneously, and dihydrocapsaicin was approximately 65% more effective in producing hypothermia than capsaicin. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: For lowering body temperature, dihydrocapsaicin is roughly two thirds more powerful than capsaicin. organism: Rat tissue_or_cell_type: Whole body, dorsal root ganglia and spinal cord experimental_model: Dose-ranging subcutaneous administration in rats with repeated dosing, antinociception testing and regional substance P measurement limitations: The founding comparison. It is a 1982 study and the antinociception endpoints are behavioural, but it is the only record here that puts a number on how the two compounds differ on temperature. exposure: Dihydrocapsaicin 0.5 to 10 mg/kg subcutaneously, single and repeated, against capsaicin evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/6184240.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dbeb69d90d490215b73d7a6f70fab0043e16cfdc8659c0daa4fda2cc0a7f6eaa", "start_char": 0, "end_char": 897, "text_sha256": "dbeb69d90d490215b73d7a6f70fab0043e16cfdc8659c0daa4fda2cc0a7f6eaa"} [dhc-p6184240] Dihydrocapsaicin-induced hypothermia and substance P depletion. (1982). https://pubmed.ncbi.nlm.nih.gov/6184240/ DOI: 10.1016/0014-2999(82)90263-1

   Complete structured claim and evidence

2. Desensitization and cross-tolerance occurred to the hypothermic effects of both capsaicin and dihydrocapsaicin in rats, and repeated administration of either compound resulted in chemogenic antinociception but not marked thermal antinociception.

   Dihydrocapsaicin → The cold-defence response that opposes induced cooling source_derived_draftungraded
   Experimental context and source evidence

   evidence_span

   {"source_cache": "artifacts/dihydrocapsaicin-research/6184240.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dbeb69d90d490215b73d7a6f70fab0043e16cfdc8659c0daa4fda2cc0a7f6eaa", "start_char": 0, "end_char": 897, "text_sha256": "dbeb69d90d490215b73d7a6f70fab0043e16cfdc8659c0daa4fda2cc0a7f6eaa"}

   experimental_model

   Dose-ranging subcutaneous administration in rats with repeated dosing, antinociception testing and regional substance P measurement

   exposure

   Dihydrocapsaicin 0.5 to 10 mg/kg subcutaneously, single and repeated, against capsaicin

   limitations

   The founding comparison. It is a 1982 study and the antinociception endpoints are behavioural, but it is the only record here that puts a number on how the two compounds differ on temperature.

   nutrient_topic

   Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin

   organism

   Rat

   plain_language

   Give it repeatedly and the cooling effect fades, and the fading carries across to capsaicin.

   primary_references

   [dhc-p6184240] Dihydrocapsaicin-induced hypothermia and substance P depletion. (1982). https://pubmed.ncbi.nlm.nih.gov/6184240/ DOI: 10.1016/0014-2999(82)90263-1

   tissue_or_cell_type

   Whole body, dorsal root ganglia and spinal cord

   Dihydrocapsaicin: the second capsaicinoid, the hypothermia it is used to induce, what the gut and liver do to it, and what it does without TRPV1 (2026-09-21) · lines 192–203

   AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Dose-ranging subcutaneous administration in rats with repeated dosing, antinociception testing and regional substance P measurement · source_derived_draft · unverified_draft

   ### dhc-early-desensitisation Desensitization and cross-tolerance occurred to the hypothermic effects of both capsaicin and dihydrocapsaicin in rats, and repeated administration of either compound resulted in chemogenic antinociception but not marked thermal antinociception. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: Give it repeatedly and the cooling effect fades, and the fading carries across to capsaicin. organism: Rat tissue_or_cell_type: Whole body, dorsal root ganglia and spinal cord experimental_model: Dose-ranging subcutaneous administration in rats with repeated dosing, antinociception testing and regional substance P measurement limitations: The founding comparison. It is a 1982 study and the antinociception endpoints are behavioural, but it is the only record here that puts a number on how the two compounds differ on temperature. exposure: Dihydrocapsaicin 0.5 to 10 mg/kg subcutaneously, single and repeated, against capsaicin evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/6184240.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dbeb69d90d490215b73d7a6f70fab0043e16cfdc8659c0daa4fda2cc0a7f6eaa", "start_char": 0, "end_char": 897, "text_sha256": "dbeb69d90d490215b73d7a6f70fab0043e16cfdc8659c0daa4fda2cc0a7f6eaa"} [dhc-p6184240] Dihydrocapsaicin-induced hypothermia and substance P depletion. (1982). https://pubmed.ncbi.nlm.nih.gov/6184240/ DOI: 10.1016/0014-2999(82)90263-1

   Complete structured claim and evidence

3. Hypothalamic TRPV1 expression, hypothalamic intracellular calcium concentration and arginine vasopressin concentration in the ventral septum were significantly higher in the dihydrocapsaicin group than in the control, resuscitation and body surface cooling groups, and the authors concluded that dihydrocapsaicin activates TRPV1 on hypothalamic cells to cause a large calcium influx which causes the release of vasopressin to induce hypothermia.

   Dihydrocapsaicin → Calcium influx into hypothalamic cells source_derived_draftungraded
   Experimental context and source evidence

   evidence_span

   {"source_cache": "artifacts/dihydrocapsaicin-research/29035676.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "bb8f6fadb6a90a5afbd08a767fde07137140f2bf8cc536207ca8619e4168bf98", "start_char": 0, "end_char": 2035, "text_sha256": "bb8f6fadb6a90a5afbd08a767fde07137140f2bf8cc536207ca8619e4168bf98"}

   experimental_model

   Four-group asphyxia arrest study in 24 male Sprague Dawley rats with immunohistochemistry and tissue assays

   exposure

   Dihydrocapsaicin against cardiopulmonary resuscitation alone and against body surface cooling

   limitations

   Proposes the central mechanism and measures each step, but with six animals per group and immunohistochemical rather than functional readouts.

   nutrient_topic

   Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin

   organism

   Rat

   plain_language

   The proposed route runs through the brain’s thermostat: calcium floods in and a hormone is released.

   primary_references

   [dhc-p29035676] The Molecular Mechanism and Neuroprotective Effect of Dihydrocapsaicin-Induced Mild Hypothermia After Cardiopulmonary Resuscitation in Rats. (2018). https://pubmed.ncbi.nlm.nih.gov/29035676/ DOI: 10.1089/ther.2017.0032

   tissue_or_cell_type

   Hypothalamus, ventral septum and cerebral cortex

   Dihydrocapsaicin: the second capsaicinoid, the hypothermia it is used to induce, what the gut and liver do to it, and what it does without TRPV1 (2026-09-21) · lines 426–437

   AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Four-group asphyxia arrest study in 24 male Sprague Dawley rats with immunohistochemistry and tissue assays · source_derived_draft · unverified_draft

   ### dhc-hypothalamic-calcium-avp Hypothalamic TRPV1 expression, hypothalamic intracellular calcium concentration and arginine vasopressin concentration in the ventral septum were significantly higher in the dihydrocapsaicin group than in the control, resuscitation and body surface cooling groups, and the authors concluded that dihydrocapsaicin activates TRPV1 on hypothalamic cells to cause a large calcium influx which causes the release of vasopressin to induce hypothermia. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: The proposed route runs through the brain’s thermostat: calcium floods in and a hormone is released. organism: Rat tissue_or_cell_type: Hypothalamus, ventral septum and cerebral cortex experimental_model: Four-group asphyxia arrest study in 24 male Sprague Dawley rats with immunohistochemistry and tissue assays limitations: Proposes the central mechanism and measures each step, but with six animals per group and immunohistochemical rather than functional readouts. exposure: Dihydrocapsaicin against cardiopulmonary resuscitation alone and against body surface cooling evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/29035676.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "bb8f6fadb6a90a5afbd08a767fde07137140f2bf8cc536207ca8619e4168bf98", "start_char": 0, "end_char": 2035, "text_sha256": "bb8f6fadb6a90a5afbd08a767fde07137140f2bf8cc536207ca8619e4168bf98"} [dhc-p29035676] The Molecular Mechanism and Neuroprotective Effect of Dihydrocapsaicin-Induced Mild Hypothermia After Cardiopulmonary Resuscitation in Rats. (2018). https://pubmed.ncbi.nlm.nih.gov/29035676/ DOI: 10.1089/ther.2017.0032

   Complete structured claim and evidence

4. In a rat model of cervical spinal cord injury, dihydrocapsaicin reliably induced systemic cooling to 32 to 33 degrees, and at both 48 hours and 6 weeks the two modes of hypothermia yielded similar improvements in neurological function and lesion size compared with normothermic controls, indicating that dihydrocapsaicin-induced hypothermia may be comparable with physical hypothermia in efficacy but more clinically feasible to administer.

   Dihydrocapsaicin → Hypothermia induced by physical means such as an ice pad or cold fluid source_derived_draftungraded
   Experimental context and source evidence

   evidence_span

   {"source_cache": "artifacts/dihydrocapsaicin-research/35675523.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "be32dc3c18b06ec73979a729e98459c00fb147186da0b9601fb1a8e96586fccf", "start_char": 0, "end_char": 1650, "text_sha256": "be32dc3c18b06ec73979a729e98459c00fb147186da0b9601fb1a8e96586fccf"}

   experimental_model

   Blinded rat cervical spinal cord injury study with telemetry and histopathology at 48 hours and 6 weeks

   exposure

   Intravenous dihydrocapsaicin totalling about 0.60 mg/kg begun after a 4 hour delay, against physical cooling, both to 33 degrees for 4 hours

   limitations

   A head-to-head against physical cooling with blinded assessment at two timepoints. It shows equivalence, not superiority, which is what the authors claim.

   nutrient_topic

   Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin

   organism

   Rat

   plain_language

   The drug worked about as well as packing the animal in cold fluid, and is easier to give.

   primary_references

   [dhc-p35675523] A Direct Comparison of Physical Versus Dihydrocapsaicin-Induced Hypothermia in a Rat Model of Traumatic Spinal Cord Injury. (2022). https://pubmed.ncbi.nlm.nih.gov/35675523/ DOI: 10.1089/ther.2021.0013

   tissue_or_cell_type

   Cervical spinal cord

   Dihydrocapsaicin: the second capsaicinoid, the hypothermia it is used to induce, what the gut and liver do to it, and what it does without TRPV1 (2026-09-21) · lines 452–463

   AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Blinded rat cervical spinal cord injury study with telemetry and histopathology at 48 hours and 6 weeks · source_derived_draft · unverified_draft

   ### dhc-matches-physical-cooling In a rat model of cervical spinal cord injury, dihydrocapsaicin reliably induced systemic cooling to 32 to 33 degrees, and at both 48 hours and 6 weeks the two modes of hypothermia yielded similar improvements in neurological function and lesion size compared with normothermic controls, indicating that dihydrocapsaicin-induced hypothermia may be comparable with physical hypothermia in efficacy but more clinically feasible to administer. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: The drug worked about as well as packing the animal in cold fluid, and is easier to give. organism: Rat tissue_or_cell_type: Cervical spinal cord experimental_model: Blinded rat cervical spinal cord injury study with telemetry and histopathology at 48 hours and 6 weeks limitations: A head-to-head against physical cooling with blinded assessment at two timepoints. It shows equivalence, not superiority, which is what the authors claim. exposure: Intravenous dihydrocapsaicin totalling about 0.60 mg/kg begun after a 4 hour delay, against physical cooling, both to 33 degrees for 4 hours evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/35675523.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "be32dc3c18b06ec73979a729e98459c00fb147186da0b9601fb1a8e96586fccf", "start_char": 0, "end_char": 1650, "text_sha256": "be32dc3c18b06ec73979a729e98459c00fb147186da0b9601fb1a8e96586fccf"} [dhc-p35675523] A Direct Comparison of Physical Versus Dihydrocapsaicin-Induced Hypothermia in a Rat Model of Traumatic Spinal Cord Injury. (2022). https://pubmed.ncbi.nlm.nih.gov/35675523/ DOI: 10.1089/ther.2021.0013

   Complete structured claim and evidence

5. Dihydrocapsaicin produced a dose-dependent drop in core temperature over 2 to 4 mg/kg subcutaneously, a loading dose followed by continuous infusion produced a rapid and prolonged drop of more than six hours within the therapeutic range of 32 to 34 degrees, and the hypothermic effect was augmented in aged mice and was not desensitised with repeated administration.

   Dihydrocapsaicin → Hypothermia induced by a drug rather than by physical cooling source_derived_draftungraded
   Experimental context and source evidence

   evidence_span

   {"source_cache": "artifacts/dihydrocapsaicin-research/24595220.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f8844f6469d0412a4fabe00ebd706924083ebc2759c847bff9da104ae4404a87", "start_char": 0, "end_char": 1882, "text_sha256": "f8844f6469d0412a4fabe00ebd706924083ebc2759c847bff9da104ae4404a87"}

   experimental_model

   Controlled prospective study in conscious unrestrained young and aged male mice with implanted thermocouples and wireless transponders

   exposure

   Dihydrocapsaicin 2 to 4 mg/kg subcutaneously, alone and combined with the TRPM8 inhibitor compound 5 at 20 to 30 mg/kg

   limitations

   Includes aged animals, which most of this collection does not. Its finding that the effect does not desensitise is the direct opposite of the 1982 rat result and the two are recorded as conflicting.

   nutrient_topic

   Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin

   organism

   Mouse

   plain_language

   Given this way the cooling did not wear off with repetition, and it worked harder in old mice than young ones.

   primary_references

   [dhc-p24595220] Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse. (2014). https://pubmed.ncbi.nlm.nih.gov/24595220/ DOI: 10.1097/ccm.0000000000000229

   tissue_or_cell_type

   Core temperature

   Dihydrocapsaicin: the second capsaicinoid, the hypothermia it is used to induce, what the gut and liver do to it, and what it does without TRPV1 (2026-09-21) · lines 270–281

   AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled prospective study in conscious unrestrained young and aged male mice with implanted thermocouples and wireless transponders · source_derived_draft · unverified_draft

   ### dhc-no-desensitisation Dihydrocapsaicin produced a dose-dependent drop in core temperature over 2 to 4 mg/kg subcutaneously, a loading dose followed by continuous infusion produced a rapid and prolonged drop of more than six hours within the therapeutic range of 32 to 34 degrees, and the hypothermic effect was augmented in aged mice and was not desensitised with repeated administration. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: Given this way the cooling did not wear off with repetition, and it worked harder in old mice than young ones. organism: Mouse tissue_or_cell_type: Core temperature experimental_model: Controlled prospective study in conscious unrestrained young and aged male mice with implanted thermocouples and wireless transponders limitations: Includes aged animals, which most of this collection does not. Its finding that the effect does not desensitise is the direct opposite of the 1982 rat result and the two are recorded as conflicting. exposure: Dihydrocapsaicin 2 to 4 mg/kg subcutaneously, alone and combined with the TRPM8 inhibitor compound 5 at 20 to 30 mg/kg evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/24595220.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f8844f6469d0412a4fabe00ebd706924083ebc2759c847bff9da104ae4404a87", "start_char": 0, "end_char": 1882, "text_sha256": "f8844f6469d0412a4fabe00ebd706924083ebc2759c847bff9da104ae4404a87"} [dhc-p24595220] Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse. (2014). https://pubmed.ncbi.nlm.nih.gov/24595220/ DOI: 10.1097/ccm.0000000000000229

   Complete structured claim and evidence

6. Comparing bolus injection with femoral vein infusion, cardiovascular effects were seen only with a large-dose dihydrocapsaicin bolus injection, and four-hour infusion at 0.75 mg/kg/h after cardiac arrest maintained a body temperature of about 34 degrees for at least eight hours with treated rats remaining viable, showing higher electrical activity during the first four hours and better neurological recovery over three days than normothermia rats.

   Dihydrocapsaicin → Heart rate source_derived_draftungraded
   Experimental context and source evidence

   evidence_span

   {"source_cache": "artifacts/dihydrocapsaicin-research/28268688.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "90c0491fa4681d112ecfc224671b763a608eeb03af4bf563955dc49ef628b851", "start_char": 0, "end_char": 1500, "text_sha256": "90c0491fa4681d112ecfc224671b763a608eeb03af4bf563955dc49ef628b851"}

   experimental_model

   Asphyxial cardiac arrest in rats comparing bolus injection with femoral vein infusion

   exposure

   Dihydrocapsaicin by bolus injection or by infusion at 0.75 mg/kg/h for four hours after cardiac arrest

   limitations

   Directly compares two routes of the same drug and finds the route decides whether the cardiovascular effects appear. Neurological recovery was followed for only three days.

   nutrient_topic

   Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin

   organism

   Rat

   plain_language

   Injected all at once it disturbs the heart; infused slowly it does not, and the animals did better.

   primary_references

   [dhc-p28268688] Dihydrocapsaicin-induced hypothermia after asphyxiai cardiac arrest in rats. (2016). https://pubmed.ncbi.nlm.nih.gov/28268688/ DOI: 10.1109/embc.2016.7591082

   tissue_or_cell_type

   Brain and cardiovascular system

   Dihydrocapsaicin: the second capsaicinoid, the hypothermia it is used to induce, what the gut and liver do to it, and what it does without TRPV1 (2026-09-21) · lines 361–372

   AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Asphyxial cardiac arrest in rats comparing bolus injection with femoral vein infusion · source_derived_draft · unverified_draft

   ### dhc-route-decides-safety Comparing bolus injection with femoral vein infusion, cardiovascular effects were seen only with a large-dose dihydrocapsaicin bolus injection, and four-hour infusion at 0.75 mg/kg/h after cardiac arrest maintained a body temperature of about 34 degrees for at least eight hours with treated rats remaining viable, showing higher electrical activity during the first four hours and better neurological recovery over three days than normothermia rats. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: Injected all at once it disturbs the heart; infused slowly it does not, and the animals did better. organism: Rat tissue_or_cell_type: Brain and cardiovascular system experimental_model: Asphyxial cardiac arrest in rats comparing bolus injection with femoral vein infusion limitations: Directly compares two routes of the same drug and finds the route decides whether the cardiovascular effects appear. Neurological recovery was followed for only three days. exposure: Dihydrocapsaicin by bolus injection or by infusion at 0.75 mg/kg/h for four hours after cardiac arrest evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/28268688.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "90c0491fa4681d112ecfc224671b763a608eeb03af4bf563955dc49ef628b851", "start_char": 0, "end_char": 1500, "text_sha256": "90c0491fa4681d112ecfc224671b763a608eeb03af4bf563955dc49ef628b851"} [dhc-p28268688] Dihydrocapsaicin-induced hypothermia after asphyxiai cardiac arrest in rats. (2016). https://pubmed.ncbi.nlm.nih.gov/28268688/ DOI: 10.1109/embc.2016.7591082

   Complete structured claim and evidence

7. In conscious young cattle, with a body weight comparable to that of an adult human, intravenous infusion of dihydrocapsaicin maintained mild hypothermia of more than 3 degrees below baseline for more than 12 hours.

   Dihydrocapsaicin → Hypothermia induced by a drug rather than by physical cooling source_derived_draftungraded
   Experimental context and source evidence

   evidence_span

   {"source_cache": "artifacts/dihydrocapsaicin-research/20932337.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "add9a23357b3b1d89126189d178c377e3b4934e1c047d4022cf4aa15fdfa6602", "start_char": 0, "end_char": 1847, "text_sha256": "add9a23357b3b1d89126189d178c377e3b4934e1c047d4022cf4aa15fdfa6602"}

   experimental_model

   Screening of a heterogeneous group of TRPV1 agonists followed by dose-response studies in three species

   exposure

   Continuous intravenous infusion of dihydrocapsaicin at 0.125 to 0.75 mg/kg/h in conscious animals

   limitations

   The reason dihydrocapsaicin rather than capsaicin is the agent used for this purpose: it was selected out of a screen. The calf arm matters because it is the only body mass here comparable to an adult human.

   nutrient_topic

   Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin

   organism

   Rat, cynomolgus monkey and calf

   plain_language

   In an animal the size of a person it held the temperature down for half a day.

   primary_references

   [dhc-p20932337] Drug-induced mild therapeutic hypothermia obtained by administration of a transient receptor potential vanilloid type 1 agonist. (2010). https://pubmed.ncbi.nlm.nih.gov/20932337/ DOI: 10.1186/1471-2261-10-51

   tissue_or_cell_type

   Whole body

   Dihydrocapsaicin: the second capsaicinoid, the hypothermia it is used to induce, what the gut and liver do to it, and what it does without TRPV1 (2026-09-21) · lines 231–242

   AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Screening of a heterogeneous group of TRPV1 agonists followed by dose-response studies in three species · source_derived_draft · unverified_draft

   ### dhc-scales-to-human-mass In conscious young cattle, with a body weight comparable to that of an adult human, intravenous infusion of dihydrocapsaicin maintained mild hypothermia of more than 3 degrees below baseline for more than 12 hours. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: In an animal the size of a person it held the temperature down for half a day. organism: Rat, cynomolgus monkey and calf tissue_or_cell_type: Whole body experimental_model: Screening of a heterogeneous group of TRPV1 agonists followed by dose-response studies in three species limitations: The reason dihydrocapsaicin rather than capsaicin is the agent used for this purpose: it was selected out of a screen. The calf arm matters because it is the only body mass here comparable to an adult human. exposure: Continuous intravenous infusion of dihydrocapsaicin at 0.125 to 0.75 mg/kg/h in conscious animals evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/20932337.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "add9a23357b3b1d89126189d178c377e3b4934e1c047d4022cf4aa15fdfa6602", "start_char": 0, "end_char": 1847, "text_sha256": "add9a23357b3b1d89126189d178c377e3b4934e1c047d4022cf4aa15fdfa6602"} [dhc-p20932337] Drug-induced mild therapeutic hypothermia obtained by administration of a transient receptor potential vanilloid type 1 agonist. (2010). https://pubmed.ncbi.nlm.nih.gov/20932337/ DOI: 10.1186/1471-2261-10-51

   Complete structured claim and evidence

8. On screening a heterogeneous group of TRPV1 agonists in conscious rats, dihydrocapsaicin displayed a desirable hypothermic profile with regard to duration, depth and control, and in rats infusion at 0.125, 0.25, 0.50 and 0.75 mg/kg/h caused maximal temperature changes against vehicle of -0.9, -1.5, -2.0 and -4.2 degrees within about one hour until the six hour infusion was stopped, with dose-dependent immediate decreases also in cynomolgus monkeys.

   Dihydrocapsaicin → Hypothermia induced by a drug rather than by physical cooling source_derived_draftungraded
   Experimental context and source evidence

   evidence_span

   {"source_cache": "artifacts/dihydrocapsaicin-research/20932337.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "add9a23357b3b1d89126189d178c377e3b4934e1c047d4022cf4aa15fdfa6602", "start_char": 0, "end_char": 1847, "text_sha256": "add9a23357b3b1d89126189d178c377e3b4934e1c047d4022cf4aa15fdfa6602"}

   experimental_model

   Screening of a heterogeneous group of TRPV1 agonists followed by dose-response studies in three species

   exposure

   Continuous intravenous infusion of dihydrocapsaicin at 0.125 to 0.75 mg/kg/h in conscious animals

   limitations

   The reason dihydrocapsaicin rather than capsaicin is the agent used for this purpose: it was selected out of a screen. The calf arm matters because it is the only body mass here comparable to an adult human.

   nutrient_topic

   Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin

   organism

   Rat, cynomolgus monkey and calf

   plain_language

   Out of a set of receptor agonists, this one gave the most controllable cooling, and the deeper the dose the deeper the drop.

   primary_references

   [dhc-p20932337] Drug-induced mild therapeutic hypothermia obtained by administration of a transient receptor potential vanilloid type 1 agonist. (2010). https://pubmed.ncbi.nlm.nih.gov/20932337/ DOI: 10.1186/1471-2261-10-51

   tissue_or_cell_type

   Whole body

   Dihydrocapsaicin: the second capsaicinoid, the hypothermia it is used to induce, what the gut and liver do to it, and what it does without TRPV1 (2026-09-21) · lines 218–229

   AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Screening of a heterogeneous group of TRPV1 agonists followed by dose-response studies in three species · source_derived_draft · unverified_draft

   ### dhc-selected-from-a-screen On screening a heterogeneous group of TRPV1 agonists in conscious rats, dihydrocapsaicin displayed a desirable hypothermic profile with regard to duration, depth and control, and in rats infusion at 0.125, 0.25, 0.50 and 0.75 mg/kg/h caused maximal temperature changes against vehicle of -0.9, -1.5, -2.0 and -4.2 degrees within about one hour until the six hour infusion was stopped, with dose-dependent immediate decreases also in cynomolgus monkeys. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: Out of a set of receptor agonists, this one gave the most controllable cooling, and the deeper the dose the deeper the drop. organism: Rat, cynomolgus monkey and calf tissue_or_cell_type: Whole body experimental_model: Screening of a heterogeneous group of TRPV1 agonists followed by dose-response studies in three species limitations: The reason dihydrocapsaicin rather than capsaicin is the agent used for this purpose: it was selected out of a screen. The calf arm matters because it is the only body mass here comparable to an adult human. exposure: Continuous intravenous infusion of dihydrocapsaicin at 0.125 to 0.75 mg/kg/h in conscious animals evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/20932337.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "add9a23357b3b1d89126189d178c377e3b4934e1c047d4022cf4aa15fdfa6602", "start_char": 0, "end_char": 1847, "text_sha256": "add9a23357b3b1d89126189d178c377e3b4934e1c047d4022cf4aa15fdfa6602"} [dhc-p20932337] Drug-induced mild therapeutic hypothermia obtained by administration of a transient receptor potential vanilloid type 1 agonist. (2010). https://pubmed.ncbi.nlm.nih.gov/20932337/ DOI: 10.1186/1471-2261-10-51

   Complete structured claim and evidence

9. In conscious mice exposed to cooling at 10 degrees, TRPV1 activation by dihydrocapsaicin substantially suppressed total electromyographic muscle activity from 25.6 to 5.1 volt-seconds per minute, abolished the tachycardic response with heart rate change falling from 204 to 3 beats per minute, and produced a profound drop in core temperature from -2.2 to -8.9 degrees.

   Dihydrocapsaicin → The cold-defence response that opposes induced cooling source_derived_draftungraded
   Experimental context and source evidence

   evidence_span

   {"source_cache": "artifacts/dihydrocapsaicin-research/24005250.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e9d99ac4cc7a031474975ac4d7f3bcff0df922dc01047fe94bd51817ef5b3fea", "start_char": 0, "end_char": 1963, "text_sha256": "e9d99ac4cc7a031474975ac4d7f3bcff0df922dc01047fe94bd51817ef5b3fea"}

   experimental_model

   Conscious mice exposed to 10 degree cooling with implanted electromyography electrodes, electrocardiography and abdominal temperature transmitters

   exposure

   TRPV1 agonist dihydrocapsaicin or TRPM8 inhibitor compound 5, with TRPM8 knockout mice as a control

   limitations

   This is the record that explains why the drug is clinically interesting rather than merely cooling: it removes the defence that makes physical cooling intolerable in a conscious patient.

   nutrient_topic

   Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin

   organism

   Mouse

   plain_language

   It switches off the shivering and racing heart that normally fight off cooling, so the temperature falls much further.

   primary_references

   [dhc-p24005250] Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition. (2013). https://pubmed.ncbi.nlm.nih.gov/24005250/ DOI: 10.1152/ajpregu.00296.2013

   tissue_or_cell_type

   Back muscle, heart and core

   Dihydrocapsaicin: the second capsaicinoid, the hypothermia it is used to induce, what the gut and liver do to it, and what it does without TRPV1 (2026-09-21) · lines 244–255

   AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Conscious mice exposed to 10 degree cooling with implanted electromyography electrodes, electrocardiography and abdominal temperature transmitters · source_derived_draft · unverified_draft

   ### dhc-suppresses-cold-defence In conscious mice exposed to cooling at 10 degrees, TRPV1 activation by dihydrocapsaicin substantially suppressed total electromyographic muscle activity from 25.6 to 5.1 volt-seconds per minute, abolished the tachycardic response with heart rate change falling from 204 to 3 beats per minute, and produced a profound drop in core temperature from -2.2 to -8.9 degrees. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: It switches off the shivering and racing heart that normally fight off cooling, so the temperature falls much further. organism: Mouse tissue_or_cell_type: Back muscle, heart and core experimental_model: Conscious mice exposed to 10 degree cooling with implanted electromyography electrodes, electrocardiography and abdominal temperature transmitters limitations: This is the record that explains why the drug is clinically interesting rather than merely cooling: it removes the defence that makes physical cooling intolerable in a conscious patient. exposure: TRPV1 agonist dihydrocapsaicin or TRPM8 inhibitor compound 5, with TRPM8 knockout mice as a control evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/24005250.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e9d99ac4cc7a031474975ac4d7f3bcff0df922dc01047fe94bd51817ef5b3fea", "start_char": 0, "end_char": 1963, "text_sha256": "e9d99ac4cc7a031474975ac4d7f3bcff0df922dc01047fe94bd51817ef5b3fea"} [dhc-p24005250] Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition. (2013). https://pubmed.ncbi.nlm.nih.gov/24005250/ DOI: 10.1152/ajpregu.00296.2013

   Complete structured claim and evidence

10. The TRPM8 inhibitor compound 5 at 20 mg/kg subcutaneously augmented the drop in core temperature during cold exposure at 8 degrees, and when combined with dihydrocapsaicin at 1.25 to 2.5 mg/kg the drop in core temperature was amplified and prolonged, so that activating warm receptors and simultaneously inhibiting cold receptors potentiated the effect.

    The TRPM8 inhibitor referred to as compound 5 → Hypothermia induced by a drug rather than by physical cooling source_derived_draftungraded
    Experimental context and source evidence

    evidence_span

    {"source_cache": "artifacts/dihydrocapsaicin-research/24595220.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f8844f6469d0412a4fabe00ebd706924083ebc2759c847bff9da104ae4404a87", "start_char": 0, "end_char": 1882, "text_sha256": "f8844f6469d0412a4fabe00ebd706924083ebc2759c847bff9da104ae4404a87"}

    experimental_model

    Controlled prospective study in conscious unrestrained young and aged male mice with implanted thermocouples and wireless transponders

    exposure

    Dihydrocapsaicin 2 to 4 mg/kg subcutaneously, alone and combined with the TRPM8 inhibitor compound 5 at 20 to 30 mg/kg

    limitations

    Includes aged animals, which most of this collection does not. Its finding that the effect does not desensitise is the direct opposite of the 1982 rat result and the two are recorded as conflicting.

    nutrient_topic

    Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin

    organism

    Mouse

    plain_language

    Blocking the cold sensor at the same time makes the cooling go deeper and last longer.

    primary_references

    [dhc-p24595220] Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse. (2014). https://pubmed.ncbi.nlm.nih.gov/24595220/ DOI: 10.1097/ccm.0000000000000229

    tissue_or_cell_type

    Core temperature

    Dihydrocapsaicin: the second capsaicinoid, the hypothermia it is used to induce, what the gut and liver do to it, and what it does without TRPV1 (2026-09-21) · lines 283–294

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled prospective study in conscious unrestrained young and aged male mice with implanted thermocouples and wireless transponders · source_derived_draft · unverified_draft

    ### dhc-trpm8-inhibition-potentiates The TRPM8 inhibitor compound 5 at 20 mg/kg subcutaneously augmented the drop in core temperature during cold exposure at 8 degrees, and when combined with dihydrocapsaicin at 1.25 to 2.5 mg/kg the drop in core temperature was amplified and prolonged, so that activating warm receptors and simultaneously inhibiting cold receptors potentiated the effect. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: Blocking the cold sensor at the same time makes the cooling go deeper and last longer. organism: Mouse tissue_or_cell_type: Core temperature experimental_model: Controlled prospective study in conscious unrestrained young and aged male mice with implanted thermocouples and wireless transponders limitations: Includes aged animals, which most of this collection does not. Its finding that the effect does not desensitise is the direct opposite of the 1982 rat result and the two are recorded as conflicting. exposure: Dihydrocapsaicin 2 to 4 mg/kg subcutaneously, alone and combined with the TRPM8 inhibitor compound 5 at 20 to 30 mg/kg evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/24595220.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f8844f6469d0412a4fabe00ebd706924083ebc2759c847bff9da104ae4404a87", "start_char": 0, "end_char": 1882, "text_sha256": "f8844f6469d0412a4fabe00ebd706924083ebc2759c847bff9da104ae4404a87"} [dhc-p24595220] Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse. (2014). https://pubmed.ncbi.nlm.nih.gov/24595220/ DOI: 10.1097/ccm.0000000000000229

    Complete structured claim and evidence