{"id":"53bf0116-c081-54f5-947c-0c763cf9fb73","stable_key":"c953cca8-774f-596d-b27a-f13c2c0b5fce:dhc-hypothalamic-calcium-avp","predicate":"increases","statement":"Hypothalamic TRPV1 expression, hypothalamic intracellular calcium concentration and arginine vasopressin concentration in the ventral septum were significantly higher in the dihydrocapsaicin group than in the control, resuscitation and body surface cooling groups, and the authors concluded that dihydrocapsaicin activates TRPV1 on hypothalamic cells to cause a large calcium influx which causes the release of vasopressin to induce hypothermia.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"d8b1a8c4-5e5c-5cde-a384-9b541ba92a1e","mechanism_event_label":"The proposed route runs through the brain’s thermostat: calcium floods in and a hormone is released.","subject":{"id":"6259a8e0-9611-5f60-9e1b-53bbd8eb1afd","slug":"dihydrocapsaicin","display_name":"Dihydrocapsaicin","entity_type_key":"small_molecule"},"object":{"id":"765754d6-50c9-5d89-b52a-bac0b5fd0156","slug":"hypothalamic-calcium-influx","display_name":"Calcium influx into hypothalamic cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d8b1a8c4-5e5c-5cde-a384-9b541ba92a1e","stable_key":"c953cca8-774f-596d-b27a-f13c2c0b5fce:dhc-hypothalamic-calcium-avp-event","event_type":"biochemical_relationship","label":"The proposed route runs through the brain’s thermostat: calcium floods in and a hormone is released.","description":"Hypothalamic TRPV1 expression, hypothalamic intracellular calcium concentration and arginine vasopressin concentration in the ventral septum were significantly higher in the dihydrocapsaicin group than in the control, resuscitation and body surface cooling groups, and the authors concluded that dihydrocapsaicin activates TRPV1 on hypothalamic cells to cause a large calcium influx which causes the release of vasopressin to induce hypothermia.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8e0c61d8-3930-51d5-bce2-25a5edfb797c","slug":"human-trpv1","display_name":"Human transient receptor potential vanilloid 1 / TRPV1","entity_type_key":"protein"},"role":"proposed_receptor","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"10d57fac-7c12-5954-9317-d5818678e670","slug":"vasopressin","display_name":"Arginine vasopressin / antidiuretic hormone","entity_type_key":"small_molecule"},"role":"released_mediator","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"996272a1-6533-5f3c-82e6-7b5c9678fe6d","slug":"ventral-septum","display_name":"Ventral septal tissue","entity_type_key":"cell_type"},"role":"measured_site","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"61257bae-68e0-5ae5-937a-da7fdd9c4301","slug":"core-body-temperature","display_name":"Core body temperature","entity_type_key":"cellular_process"},"role":"downstream_endpoint","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"6259a8e0-9611-5f60-9e1b-53bbd8eb1afd","slug":"dihydrocapsaicin","display_name":"Dihydrocapsaicin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"765754d6-50c9-5d89-b52a-bac0b5fd0156","slug":"hypothalamic-calcium-influx","display_name":"Calcium influx into hypothalamic cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/dihydrocapsaicin-research/29035676.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"bb8f6fadb6a90a5afbd08a767fde07137140f2bf8cc536207ca8619e4168bf98\", \"start_char\": 0, \"end_char\": 2035, \"text_sha256\": \"bb8f6fadb6a90a5afbd08a767fde07137140f2bf8cc536207ca8619e4168bf98\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Four-group asphyxia arrest study in 24 male Sprague Dawley rats with immunohistochemistry and tissue assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Dihydrocapsaicin against cardiopulmonary resuscitation alone and against body surface cooling","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Proposes the central mechanism and measures each step, but with six animals per group and immunohistochemical rather than functional readouts.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin.","comparator":null,"unit":null,"notes":"","entity":{"slug":"dihydrocapsaicin","display_name":"Dihydrocapsaicin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rat","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The proposed route runs through the brain’s thermostat: calcium floods in and a hormone is released.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[dhc-p29035676] The Molecular Mechanism and Neuroprotective Effect of Dihydrocapsaicin-Induced Mild Hypothermia After Cardiopulmonary Resuscitation in Rats. (2018). https://pubmed.ncbi.nlm.nih.gov/29035676/ DOI: 10.1089/ther.2017.0032","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Hypothalamus, ventral septum and cerebral cortex","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9c3a71dc-172b-5a74-80c7-e6611f0d0a30","evidence_kind":"source_excerpt","locator":"Lines 426-437","start_line":426,"end_line":437,"excerpt":"### dhc-hypothalamic-calcium-avp\nHypothalamic TRPV1 expression, hypothalamic intracellular calcium concentration and arginine vasopressin concentration in the ventral septum were significantly higher in the dihydrocapsaicin group than in the control, resuscitation and body surface cooling groups, and the authors concluded that dihydrocapsaicin activates TRPV1 on hypothalamic cells to cause a large calcium influx which causes the release of vasopressin to induce hypothermia.\nCondition category: normal\nnutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin.\nplain_language: The proposed route runs through the brain’s thermostat: calcium floods in and a hormone is released.\norganism: Rat\ntissue_or_cell_type: Hypothalamus, ventral septum and cerebral cortex\nexperimental_model: Four-group asphyxia arrest study in 24 male Sprague Dawley rats with immunohistochemistry and tissue assays\nlimitations: Proposes the central mechanism and measures each step, but with six animals per group and immunohistochemical rather than functional readouts.\nexposure: Dihydrocapsaicin against cardiopulmonary resuscitation alone and against body surface cooling\nevidence_span: {\"source_cache\": \"artifacts/dihydrocapsaicin-research/29035676.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"bb8f6fadb6a90a5afbd08a767fde07137140f2bf8cc536207ca8619e4168bf98\", \"start_char\": 0, \"end_char\": 2035, \"text_sha256\": \"bb8f6fadb6a90a5afbd08a767fde07137140f2bf8cc536207ca8619e4168bf98\"}\n[dhc-p29035676] The Molecular Mechanism and Neuroprotective Effect of Dihydrocapsaicin-Induced Mild Hypothermia After Cardiopulmonary Resuscitation in Rats. (2018). https://pubmed.ncbi.nlm.nih.gov/29035676/ DOI: 10.1089/ther.2017.0032","model_system":"Four-group asphyxia arrest study in 24 male Sprague Dawley rats with immunohistochemistry and tissue assays","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [dhc-p29035676] The Molecular Mechanism and Neuroprotective Effect of Dihydrocapsaicin-Induced Mild Hypothermia After Cardiopulmonary Resuscitation in Rats. (2018). https://pubmed.ncbi.nlm.nih.gov/29035676/ DOI: 10.1089/ther.2017.0032","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"263a8425-969d-5a1b-8a9b-6101ba6a26a7","stable_key":"import-c953cca8-774f-596d-b27a-f13c2c0b5fce","title":"Dihydrocapsaicin: the second capsaicinoid, the hypothermia it is used to induce, what the gut and liver do to it, and what it does without TRPV1 (2026-09-21)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"97d90ff5dc65dc321068c3e2a0525585f32b2e17eb0c6bfa0d9ef26dc2d6c5a3","revision_id":"dbdc1ad7-a05a-579d-b2aa-c4348e3efc40","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}