{"id":"b05ffb40-0aa6-55a7-ac30-fdb005a42361","stable_key":"c953cca8-774f-596d-b27a-f13c2c0b5fce:dhc-matches-physical-cooling","predicate":"reported_comparison","statement":"In a rat model of cervical spinal cord injury, dihydrocapsaicin reliably induced systemic cooling to 32 to 33 degrees, and at both 48 hours and 6 weeks the two modes of hypothermia yielded similar improvements in neurological function and lesion size compared with normothermic controls, indicating that dihydrocapsaicin-induced hypothermia may be comparable with physical hypothermia in efficacy but more clinically feasible to administer.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"80845f83-28e0-577a-a7be-6ae92fc0ae96","mechanism_event_label":"The drug worked about as well as packing the animal in cold fluid, and is easier to give.","subject":{"id":"6259a8e0-9611-5f60-9e1b-53bbd8eb1afd","slug":"dihydrocapsaicin","display_name":"Dihydrocapsaicin","entity_type_key":"small_molecule"},"object":{"id":"6acb689f-5b37-547e-a884-d916fd96f138","slug":"physical-cooling","display_name":"Hypothermia induced by physical means such as an ice pad or cold fluid","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"80845f83-28e0-577a-a7be-6ae92fc0ae96","stable_key":"c953cca8-774f-596d-b27a-f13c2c0b5fce:dhc-matches-physical-cooling-event","event_type":"observed_intervention","label":"The drug worked about as well as packing the animal in cold fluid, and is easier to give.","description":"In a rat model of cervical spinal cord injury, dihydrocapsaicin reliably induced systemic cooling to 32 to 33 degrees, and at both 48 hours and 6 weeks the two modes of hypothermia yielded similar improvements in neurological function and lesion size compared with normothermic controls, indicating that dihydrocapsaicin-induced hypothermia may be comparable with physical hypothermia in efficacy but more clinically feasible to administer.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"adec485f-488f-5c33-819e-7776560e1a94","slug":"spinal-cord-injury-lesion","display_name":"Lesion size after cervical spinal cord injury","entity_type_key":"cellular_process"},"role":"measured_endpoint","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"61257bae-68e0-5ae5-937a-da7fdd9c4301","slug":"core-body-temperature","display_name":"Core body temperature","entity_type_key":"cellular_process"},"role":"matched_target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6259a8e0-9611-5f60-9e1b-53bbd8eb1afd","slug":"dihydrocapsaicin","display_name":"Dihydrocapsaicin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"6acb689f-5b37-547e-a884-d916fd96f138","slug":"physical-cooling","display_name":"Hypothermia induced by physical means such as an ice pad or cold fluid","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/dihydrocapsaicin-research/35675523.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"be32dc3c18b06ec73979a729e98459c00fb147186da0b9601fb1a8e96586fccf\", \"start_char\": 0, \"end_char\": 1650, \"text_sha256\": \"be32dc3c18b06ec73979a729e98459c00fb147186da0b9601fb1a8e96586fccf\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Blinded rat cervical spinal cord injury study with telemetry and histopathology at 48 hours and 6 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Intravenous dihydrocapsaicin totalling about 0.60 mg/kg begun after a 4 hour delay, against physical cooling, both to 33 degrees for 4 hours","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A head-to-head against physical cooling with blinded assessment at two timepoints. It shows equivalence, not superiority, which is what the authors claim.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin.","comparator":null,"unit":null,"notes":"","entity":{"slug":"dihydrocapsaicin","display_name":"Dihydrocapsaicin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rat","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The drug worked about as well as packing the animal in cold fluid, and is easier to give.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[dhc-p35675523] A Direct Comparison of Physical Versus Dihydrocapsaicin-Induced Hypothermia in a Rat Model of Traumatic Spinal Cord Injury. (2022). https://pubmed.ncbi.nlm.nih.gov/35675523/ DOI: 10.1089/ther.2021.0013","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Cervical spinal cord","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"adba4aa2-6c39-54a7-9e4e-e3177648b626","evidence_kind":"source_excerpt","locator":"Lines 452-463","start_line":452,"end_line":463,"excerpt":"### dhc-matches-physical-cooling\nIn a rat model of cervical spinal cord injury, dihydrocapsaicin reliably induced systemic cooling to 32 to 33 degrees, and at both 48 hours and 6 weeks the two modes of hypothermia yielded similar improvements in neurological function and lesion size compared with normothermic controls, indicating that dihydrocapsaicin-induced hypothermia may be comparable with physical hypothermia in efficacy but more clinically feasible to administer.\nCondition category: normal\nnutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin.\nplain_language: The drug worked about as well as packing the animal in cold fluid, and is easier to give.\norganism: Rat\ntissue_or_cell_type: Cervical spinal cord\nexperimental_model: Blinded rat cervical spinal cord injury study with telemetry and histopathology at 48 hours and 6 weeks\nlimitations: A head-to-head against physical cooling with blinded assessment at two timepoints. It shows equivalence, not superiority, which is what the authors claim.\nexposure: Intravenous dihydrocapsaicin totalling about 0.60 mg/kg begun after a 4 hour delay, against physical cooling, both to 33 degrees for 4 hours\nevidence_span: {\"source_cache\": \"artifacts/dihydrocapsaicin-research/35675523.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"be32dc3c18b06ec73979a729e98459c00fb147186da0b9601fb1a8e96586fccf\", \"start_char\": 0, \"end_char\": 1650, \"text_sha256\": \"be32dc3c18b06ec73979a729e98459c00fb147186da0b9601fb1a8e96586fccf\"}\n[dhc-p35675523] A Direct Comparison of Physical Versus Dihydrocapsaicin-Induced Hypothermia in a Rat Model of Traumatic Spinal Cord Injury. 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