Hypothermia induced by a drug rather than by physical cooling

evidence_span

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experimental_model

Randomised seven-group study in 144 male Sprague Dawley rats after middle cerebral artery occlusion

exposure

Low-dose dihydrocapsaicin at 0.5 mg/kg or high-dose at 1.5 mg/kg, an ice pad at 31 degrees, and the combination, with an external-temperature-control arm

limitations

A large randomised design with a dose-response surprise: the high dose alone did nothing while the low dose worked. That non-monotonicity is recorded because it contradicts the simple dose-response in the other records.

nutrient_topic

Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin

organism

Rat

plain_language

Drug plus ice pack cooled faster and protected better than either on its own.

primary_references

[dhc-p30090648] Synergistically Induced Hypothermia and Enhanced Neuroprotection by Pharmacological and Physical Approaches in Stroke. (2018). https://pubmed.ncbi.nlm.nih.gov/30090648/ DOI: 10.14336/ad.2017.0817

tissue_or_cell_type

Brain

Dihydrocapsaicin: the second capsaicinoid, the hypothermia it is used to induce, what the gut and liver do to it, and what it does without TRPV1 (2026-09-21) · lines 335–346

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomised seven-group study in 144 male Sprague Dawley rats after middle cerebral artery occlusion · source_derived_draft · unverified_draft

### dhc-combination-beats-either Combination therapy of low-dose dihydrocapsaicin and an ice pad significantly improved every measured outcome compared with monotherapies, achieving hypothermia faster by 28.6% than the ice pad, 350% than low-dose dihydrocapsaicin and 200% than high-dose dihydrocapsaicin alone, reducing neurological deficits by 63% against 26% with low-dose alone, reducing reactive oxygen species at 6 and 24 hours, increasing ATP by 42.9% against 25%, and decreasing apoptotic cell death by 48.5% against 24.9%. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: Drug plus ice pack cooled faster and protected better than either on its own. organism: Rat tissue_or_cell_type: Brain experimental_model: Randomised seven-group study in 144 male Sprague Dawley rats after middle cerebral artery occlusion limitations: A large randomised design with a dose-response surprise: the high dose alone did nothing while the low dose worked. That non-monotonicity is recorded because it contradicts the simple dose-response in the other records. exposure: Low-dose dihydrocapsaicin at 0.5 mg/kg or high-dose at 1.5 mg/kg, an ice pad at 31 degrees, and the combination, with an external-temperature-control arm evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/30090648.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e688b4cd16fdd3847d8fe10113d243edf17839f32bef46fe85790a18ad6b920c", "start_char": 0, "end_char": 2110, "text_sha256": "e688b4cd16fdd3847d8fe10113d243edf17839f32bef46fe85790a18ad6b920c"} [dhc-p30090648] Synergistically Induced Hypothermia and Enhanced Neuroprotection by Pharmacological and Physical Approaches in Stroke. (2018). https://pubmed.ncbi.nlm.nih.gov/30090648/ DOI: 10.14336/ad.2017.0817

availability_state

machinery_impairment Imported condition classification; unverified.

evidence_span

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experimental_model

Focal cerebral ischaemia-reperfusion in conscious wild-type and TRPV1 knockout mice with osmotic-pump infusion

exposure

Dihydrocapsaicin 1.25 mg/kg subcutaneously, begun 90 minutes after the start of reperfusion, with normothermia by external heat support as a control arm

limitations

The two control arms are what make this the strongest record here: the knockout shows the receptor is required, and the heat-support arm shows the temperature drop rather than receptor activation is what protects.

nutrient_topic

Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin

organism

Mouse

plain_language

The stroke damage fell by almost nine tenths, and only when the animal was actually allowed to get cold.

primary_references

[dhc-p24305062] Pharmacologically induced hypothermia via TRPV1 channel agonism provides neuroprotection following ischemic stroke when initiated 90 min after reperfusion. (2014). https://pubmed.ncbi.nlm.nih.gov/24305062/ DOI: 10.1152/ajpregu.00329.2013

tissue_or_cell_type

Brain and cardiovascular system

trigger_kind

machinery_impairment Imported condition classification; unverified.

Dihydrocapsaicin: the second capsaicinoid, the hypothermia it is used to induce, what the gut and liver do to it, and what it does without TRPV1 (2026-09-21) · lines 309–320

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Focal cerebral ischaemia-reperfusion in conscious wild-type and TRPV1 knockout mice with osmotic-pump infusion · source_derived_draft · unverified_draft

### dhc-infarct-reduction In stroke mice, dihydrocapsaicin infusion begun 90 minutes after the start of reperfusion produced hypothermia, decreased infarct volume by 87% and improved neurofunctional score, and the hypothermic and neuroprotective effects were absent in TRPV1 knockout mice or in mice maintained normothermic with heat support. Condition category: machinery_impairment nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: The stroke damage fell by almost nine tenths, and only when the animal was actually allowed to get cold. organism: Mouse tissue_or_cell_type: Brain and cardiovascular system experimental_model: Focal cerebral ischaemia-reperfusion in conscious wild-type and TRPV1 knockout mice with osmotic-pump infusion limitations: The two control arms are what make this the strongest record here: the knockout shows the receptor is required, and the heat-support arm shows the temperature drop rather than receptor activation is what protects. exposure: Dihydrocapsaicin 1.25 mg/kg subcutaneously, begun 90 minutes after the start of reperfusion, with normothermia by external heat support as a control arm evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/24305062.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6f48560ff0df2e92e757c483dad96056155b0b629ddf0b5d5b41416201adfe17", "start_char": 0, "end_char": 1711, "text_sha256": "6f48560ff0df2e92e757c483dad96056155b0b629ddf0b5d5b41416201adfe17"} [dhc-p24305062] Pharmacologically induced hypothermia via TRPV1 channel agonism provides neuroprotection following ischemic stroke when initiated 90 min after reperfusion. (2014). https://pubmed.ncbi.nlm.nih.gov/24305062/ DOI: 10.1152/ajpregu.00329.2013

evidence_span

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experimental_model

Long-term outcome study in mice with diffusion tensor imaging and one-month behavioural follow-up

exposure

A single 8 hour treatment of dihydrocapsaicin-induced hypothermia begun 3.5 hours after stroke

limitations

The long follow-up and the remote-injury endpoint are unusual and valuable. Still one model and one species.

nutrient_topic

Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin

organism

Mouse

plain_language

Cooling for eight hours protected not only the injured area but a distant region that degenerates later, and the benefit was still there a month on.

primary_references

[dhc-p29247238] TRPV1-mediated Pharmacological Hypothermia Promotes Improved Functional Recovery Following Ischemic Stroke. (2017). https://pubmed.ncbi.nlm.nih.gov/29247238/ DOI: 10.1038/s41598-017-17548-y

tissue_or_cell_type

Cortex and thalamus

Dihydrocapsaicin: the second capsaicinoid, the hypothermia it is used to induce, what the gut and liver do to it, and what it does without TRPV1 (2026-09-21) · lines 322–333

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Long-term outcome study in mice with diffusion tensor imaging and one-month behavioural follow-up · source_derived_draft · unverified_draft

### dhc-secondary-injury-reduced Hypothermia by dihydrocapsaicin initiated 3.5 hours after stroke significantly reduced primary cortical injury and also reduced secondary thalamic injury, with treated mice showing 53% smaller thalamic lesion size, decreased neuronal loss and astrogliosis in the thalamus and less thalamic fibre loss by diffusion tensor imaging, and a single 8 hour treatment produced improved behavioural recovery at one month after stroke. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: Cooling for eight hours protected not only the injured area but a distant region that degenerates later, and the benefit was still there a month on. organism: Mouse tissue_or_cell_type: Cortex and thalamus experimental_model: Long-term outcome study in mice with diffusion tensor imaging and one-month behavioural follow-up limitations: The long follow-up and the remote-injury endpoint are unusual and valuable. Still one model and one species. exposure: A single 8 hour treatment of dihydrocapsaicin-induced hypothermia begun 3.5 hours after stroke evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/29247238.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "02b1d92f9972bd978e0b35a0a4f8130145f3dcd6832ff8a95f9d022fc7a4ce08", "start_char": 0, "end_char": 1517, "text_sha256": "02b1d92f9972bd978e0b35a0a4f8130145f3dcd6832ff8a95f9d022fc7a4ce08"} [dhc-p29247238] TRPV1-mediated Pharmacological Hypothermia Promotes Improved Functional Recovery Following Ischemic Stroke. (2017). https://pubmed.ncbi.nlm.nih.gov/29247238/ DOI: 10.1038/s41598-017-17548-y

availability_state

machinery_impairment Imported condition classification; unverified.

evidence_span

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experimental_model

Focal cerebral ischaemia-reperfusion in conscious wild-type and TRPV1 knockout mice with osmotic-pump infusion

exposure

Dihydrocapsaicin 1.25 mg/kg subcutaneously, begun 90 minutes after the start of reperfusion, with normothermia by external heat support as a control arm

limitations

The two control arms are what make this the strongest record here: the knockout shows the receptor is required, and the heat-support arm shows the temperature drop rather than receptor activation is what protects.

nutrient_topic

Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin

organism

Mouse

plain_language

The cooling happens through the receptor, and in these mice it barely touched the circulation.

primary_references

[dhc-p24305062] Pharmacologically induced hypothermia via TRPV1 channel agonism provides neuroprotection following ischemic stroke when initiated 90 min after reperfusion. (2014). https://pubmed.ncbi.nlm.nih.gov/24305062/ DOI: 10.1152/ajpregu.00329.2013

tissue_or_cell_type

Brain and cardiovascular system

trigger_kind

machinery_impairment Imported condition classification; unverified.

Dihydrocapsaicin: the second capsaicinoid, the hypothermia it is used to induce, what the gut and liver do to it, and what it does without TRPV1 (2026-09-21) · lines 296–307

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Focal cerebral ischaemia-reperfusion in conscious wild-type and TRPV1 knockout mice with osmotic-pump infusion · source_derived_draft · unverified_draft

### dhc-hypothermia-requires-trpv1 Dihydrocapsaicin at 1.25 mg/kg produced a stable drop in core temperature to 33 degrees in naive and ischaemia-reperfusion mice but not in TRPV1 knockout mice, and had no measurable effect on heart rate or cerebral perfusion while producing a slight transient drop in mean arterial pressure of less than 6 millimetres of mercury. Condition category: machinery_impairment nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: The cooling happens through the receptor, and in these mice it barely touched the circulation. organism: Mouse tissue_or_cell_type: Brain and cardiovascular system experimental_model: Focal cerebral ischaemia-reperfusion in conscious wild-type and TRPV1 knockout mice with osmotic-pump infusion limitations: The two control arms are what make this the strongest record here: the knockout shows the receptor is required, and the heat-support arm shows the temperature drop rather than receptor activation is what protects. exposure: Dihydrocapsaicin 1.25 mg/kg subcutaneously, begun 90 minutes after the start of reperfusion, with normothermia by external heat support as a control arm evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/24305062.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6f48560ff0df2e92e757c483dad96056155b0b629ddf0b5d5b41416201adfe17", "start_char": 0, "end_char": 1711, "text_sha256": "6f48560ff0df2e92e757c483dad96056155b0b629ddf0b5d5b41416201adfe17"} [dhc-p24305062] Pharmacologically induced hypothermia via TRPV1 channel agonism provides neuroprotection following ischemic stroke when initiated 90 min after reperfusion. (2014). https://pubmed.ncbi.nlm.nih.gov/24305062/ DOI: 10.1152/ajpregu.00329.2013

evidence_span

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experimental_model

Controlled prospective study in conscious unrestrained young and aged male mice with implanted thermocouples and wireless transponders

exposure

Dihydrocapsaicin 2 to 4 mg/kg subcutaneously, alone and combined with the TRPM8 inhibitor compound 5 at 20 to 30 mg/kg

limitations

Includes aged animals, which most of this collection does not. Its finding that the effect does not desensitise is the direct opposite of the 1982 rat result and the two are recorded as conflicting.

nutrient_topic

Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin

organism

Mouse

plain_language

Given this way the cooling did not wear off with repetition, and it worked harder in old mice than young ones.

primary_references

[dhc-p24595220] Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse. (2014). https://pubmed.ncbi.nlm.nih.gov/24595220/ DOI: 10.1097/ccm.0000000000000229

tissue_or_cell_type

Core temperature

Dihydrocapsaicin: the second capsaicinoid, the hypothermia it is used to induce, what the gut and liver do to it, and what it does without TRPV1 (2026-09-21) · lines 270–281

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled prospective study in conscious unrestrained young and aged male mice with implanted thermocouples and wireless transponders · source_derived_draft · unverified_draft

### dhc-no-desensitisation Dihydrocapsaicin produced a dose-dependent drop in core temperature over 2 to 4 mg/kg subcutaneously, a loading dose followed by continuous infusion produced a rapid and prolonged drop of more than six hours within the therapeutic range of 32 to 34 degrees, and the hypothermic effect was augmented in aged mice and was not desensitised with repeated administration. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: Given this way the cooling did not wear off with repetition, and it worked harder in old mice than young ones. organism: Mouse tissue_or_cell_type: Core temperature experimental_model: Controlled prospective study in conscious unrestrained young and aged male mice with implanted thermocouples and wireless transponders limitations: Includes aged animals, which most of this collection does not. Its finding that the effect does not desensitise is the direct opposite of the 1982 rat result and the two are recorded as conflicting. exposure: Dihydrocapsaicin 2 to 4 mg/kg subcutaneously, alone and combined with the TRPM8 inhibitor compound 5 at 20 to 30 mg/kg evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/24595220.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f8844f6469d0412a4fabe00ebd706924083ebc2759c847bff9da104ae4404a87", "start_char": 0, "end_char": 1882, "text_sha256": "f8844f6469d0412a4fabe00ebd706924083ebc2759c847bff9da104ae4404a87"} [dhc-p24595220] Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse. (2014). https://pubmed.ncbi.nlm.nih.gov/24595220/ DOI: 10.1097/ccm.0000000000000229

evidence_span

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experimental_model

Screening of a heterogeneous group of TRPV1 agonists followed by dose-response studies in three species

exposure

Continuous intravenous infusion of dihydrocapsaicin at 0.125 to 0.75 mg/kg/h in conscious animals

limitations

The reason dihydrocapsaicin rather than capsaicin is the agent used for this purpose: it was selected out of a screen. The calf arm matters because it is the only body mass here comparable to an adult human.

nutrient_topic

Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin

organism

Rat, cynomolgus monkey and calf

plain_language

In an animal the size of a person it held the temperature down for half a day.

primary_references

[dhc-p20932337] Drug-induced mild therapeutic hypothermia obtained by administration of a transient receptor potential vanilloid type 1 agonist. (2010). https://pubmed.ncbi.nlm.nih.gov/20932337/ DOI: 10.1186/1471-2261-10-51

tissue_or_cell_type

Whole body

Dihydrocapsaicin: the second capsaicinoid, the hypothermia it is used to induce, what the gut and liver do to it, and what it does without TRPV1 (2026-09-21) · lines 231–242

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Screening of a heterogeneous group of TRPV1 agonists followed by dose-response studies in three species · source_derived_draft · unverified_draft

### dhc-scales-to-human-mass In conscious young cattle, with a body weight comparable to that of an adult human, intravenous infusion of dihydrocapsaicin maintained mild hypothermia of more than 3 degrees below baseline for more than 12 hours. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: In an animal the size of a person it held the temperature down for half a day. organism: Rat, cynomolgus monkey and calf tissue_or_cell_type: Whole body experimental_model: Screening of a heterogeneous group of TRPV1 agonists followed by dose-response studies in three species limitations: The reason dihydrocapsaicin rather than capsaicin is the agent used for this purpose: it was selected out of a screen. The calf arm matters because it is the only body mass here comparable to an adult human. exposure: Continuous intravenous infusion of dihydrocapsaicin at 0.125 to 0.75 mg/kg/h in conscious animals evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/20932337.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "add9a23357b3b1d89126189d178c377e3b4934e1c047d4022cf4aa15fdfa6602", "start_char": 0, "end_char": 1847, "text_sha256": "add9a23357b3b1d89126189d178c377e3b4934e1c047d4022cf4aa15fdfa6602"} [dhc-p20932337] Drug-induced mild therapeutic hypothermia obtained by administration of a transient receptor potential vanilloid type 1 agonist. (2010). https://pubmed.ncbi.nlm.nih.gov/20932337/ DOI: 10.1186/1471-2261-10-51

evidence_span

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experimental_model

Screening of a heterogeneous group of TRPV1 agonists followed by dose-response studies in three species

exposure

Continuous intravenous infusion of dihydrocapsaicin at 0.125 to 0.75 mg/kg/h in conscious animals

limitations

The reason dihydrocapsaicin rather than capsaicin is the agent used for this purpose: it was selected out of a screen. The calf arm matters because it is the only body mass here comparable to an adult human.

nutrient_topic

Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin

organism

Rat, cynomolgus monkey and calf

plain_language

Out of a set of receptor agonists, this one gave the most controllable cooling, and the deeper the dose the deeper the drop.

primary_references

[dhc-p20932337] Drug-induced mild therapeutic hypothermia obtained by administration of a transient receptor potential vanilloid type 1 agonist. (2010). https://pubmed.ncbi.nlm.nih.gov/20932337/ DOI: 10.1186/1471-2261-10-51

tissue_or_cell_type

Whole body

Dihydrocapsaicin: the second capsaicinoid, the hypothermia it is used to induce, what the gut and liver do to it, and what it does without TRPV1 (2026-09-21) · lines 218–229

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Screening of a heterogeneous group of TRPV1 agonists followed by dose-response studies in three species · source_derived_draft · unverified_draft

### dhc-selected-from-a-screen On screening a heterogeneous group of TRPV1 agonists in conscious rats, dihydrocapsaicin displayed a desirable hypothermic profile with regard to duration, depth and control, and in rats infusion at 0.125, 0.25, 0.50 and 0.75 mg/kg/h caused maximal temperature changes against vehicle of -0.9, -1.5, -2.0 and -4.2 degrees within about one hour until the six hour infusion was stopped, with dose-dependent immediate decreases also in cynomolgus monkeys. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: Out of a set of receptor agonists, this one gave the most controllable cooling, and the deeper the dose the deeper the drop. organism: Rat, cynomolgus monkey and calf tissue_or_cell_type: Whole body experimental_model: Screening of a heterogeneous group of TRPV1 agonists followed by dose-response studies in three species limitations: The reason dihydrocapsaicin rather than capsaicin is the agent used for this purpose: it was selected out of a screen. The calf arm matters because it is the only body mass here comparable to an adult human. exposure: Continuous intravenous infusion of dihydrocapsaicin at 0.125 to 0.75 mg/kg/h in conscious animals evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/20932337.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "add9a23357b3b1d89126189d178c377e3b4934e1c047d4022cf4aa15fdfa6602", "start_char": 0, "end_char": 1847, "text_sha256": "add9a23357b3b1d89126189d178c377e3b4934e1c047d4022cf4aa15fdfa6602"} [dhc-p20932337] Drug-induced mild therapeutic hypothermia obtained by administration of a transient receptor potential vanilloid type 1 agonist. (2010). https://pubmed.ncbi.nlm.nih.gov/20932337/ DOI: 10.1186/1471-2261-10-51

evidence_span

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experimental_model

Controlled prospective study in conscious unrestrained young and aged male mice with implanted thermocouples and wireless transponders

exposure

Dihydrocapsaicin 2 to 4 mg/kg subcutaneously, alone and combined with the TRPM8 inhibitor compound 5 at 20 to 30 mg/kg

limitations

Includes aged animals, which most of this collection does not. Its finding that the effect does not desensitise is the direct opposite of the 1982 rat result and the two are recorded as conflicting.

nutrient_topic

Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin

organism

Mouse

plain_language

Blocking the cold sensor at the same time makes the cooling go deeper and last longer.

primary_references

[dhc-p24595220] Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse. (2014). https://pubmed.ncbi.nlm.nih.gov/24595220/ DOI: 10.1097/ccm.0000000000000229

tissue_or_cell_type

Core temperature

Dihydrocapsaicin: the second capsaicinoid, the hypothermia it is used to induce, what the gut and liver do to it, and what it does without TRPV1 (2026-09-21) · lines 283–294

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Controlled prospective study in conscious unrestrained young and aged male mice with implanted thermocouples and wireless transponders · source_derived_draft · unverified_draft

### dhc-trpm8-inhibition-potentiates The TRPM8 inhibitor compound 5 at 20 mg/kg subcutaneously augmented the drop in core temperature during cold exposure at 8 degrees, and when combined with dihydrocapsaicin at 1.25 to 2.5 mg/kg the drop in core temperature was amplified and prolonged, so that activating warm receptors and simultaneously inhibiting cold receptors potentiated the effect. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: Blocking the cold sensor at the same time makes the cooling go deeper and last longer. organism: Mouse tissue_or_cell_type: Core temperature experimental_model: Controlled prospective study in conscious unrestrained young and aged male mice with implanted thermocouples and wireless transponders limitations: Includes aged animals, which most of this collection does not. Its finding that the effect does not desensitise is the direct opposite of the 1982 rat result and the two are recorded as conflicting. exposure: Dihydrocapsaicin 2 to 4 mg/kg subcutaneously, alone and combined with the TRPM8 inhibitor compound 5 at 20 to 30 mg/kg evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/24595220.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f8844f6469d0412a4fabe00ebd706924083ebc2759c847bff9da104ae4404a87", "start_char": 0, "end_char": 1882, "text_sha256": "f8844f6469d0412a4fabe00ebd706924083ebc2759c847bff9da104ae4404a87"} [dhc-p24595220] Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse. (2014). https://pubmed.ncbi.nlm.nih.gov/24595220/ DOI: 10.1097/ccm.0000000000000229