Component
Secondary thalamic injury after cortical stroke
Secondary thalamic injury after cortical stroke. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Hypothermia by dihydrocapsaicin initiated 3.5 hours after stroke significantly reduced primary cortical injury and also reduced secondary thalamic injury, with treated mice showing 53% smaller thalamic lesion size, decreased neuronal loss and astrogliosis in the thalamus and less thalamic fibre loss by diffusion tensor imaging, and a single 8 hour treatment produced improved behavioural recovery at one month after stroke.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/dihydrocapsaicin-research/29247238.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "02b1d92f9972bd978e0b35a0a4f8130145f3dcd6832ff8a95f9d022fc7a4ce08", "start_char": 0, "end_char": 1517, "text_sha256": "02b1d92f9972bd978e0b35a0a4f8130145f3dcd6832ff8a95f9d022fc7a4ce08"}
- experimental_model
- Long-term outcome study in mice with diffusion tensor imaging and one-month behavioural follow-up
- exposure
- A single 8 hour treatment of dihydrocapsaicin-induced hypothermia begun 3.5 hours after stroke
- limitations
- The long follow-up and the remote-injury endpoint are unusual and valuable. Still one model and one species.
- nutrient_topic
- Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin
- organism
- Mouse
- plain_language
- Cooling for eight hours protected not only the injured area but a distant region that degenerates later, and the benefit was still there a month on.
- primary_references
- [dhc-p29247238] TRPV1-mediated Pharmacological Hypothermia Promotes Improved Functional Recovery Following Ischemic Stroke. (2017). https://pubmed.ncbi.nlm.nih.gov/29247238/ DOI: 10.1038/s41598-017-17548-y
- tissue_or_cell_type
- Cortex and thalamus
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Long-term outcome study in mice with diffusion tensor imaging and one-month behavioural follow-up · source_derived_draft · unverified_draft
### dhc-secondary-injury-reduced Hypothermia by dihydrocapsaicin initiated 3.5 hours after stroke significantly reduced primary cortical injury and also reduced secondary thalamic injury, with treated mice showing 53% smaller thalamic lesion size, decreased neuronal loss and astrogliosis in the thalamus and less thalamic fibre loss by diffusion tensor imaging, and a single 8 hour treatment produced improved behavioural recovery at one month after stroke. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: Cooling for eight hours protected not only the injured area but a distant region that degenerates later, and the benefit was still there a month on. organism: Mouse tissue_or_cell_type: Cortex and thalamus experimental_model: Long-term outcome study in mice with diffusion tensor imaging and one-month behavioural follow-up limitations: The long follow-up and the remote-injury endpoint are unusual and valuable. Still one model and one species. exposure: A single 8 hour treatment of dihydrocapsaicin-induced hypothermia begun 3.5 hours after stroke evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/29247238.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "02b1d92f9972bd978e0b35a0a4f8130145f3dcd6832ff8a95f9d022fc7a4ce08", "start_char": 0, "end_char": 1517, "text_sha256": "02b1d92f9972bd978e0b35a0a4f8130145f3dcd6832ff8a95f9d022fc7a4ce08"} [dhc-p29247238] TRPV1-mediated Pharmacological Hypothermia Promotes Improved Functional Recovery Following Ischemic Stroke. (2017). https://pubmed.ncbi.nlm.nih.gov/29247238/ DOI: 10.1038/s41598-017-17548-y
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.