Component

Human cannabinoid receptor 2 / CB2 / CNR2

Human cannabinoid receptor 2 / CB2 / CNR2. Species, exposure and limitations are retained in each linked claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. The cryo-EM structure of the human CB2 receptor in complex with Gi resolved the active-state signalling complex.

    Human cannabinoid receptor 2 / CB2 / CNR2 → Heterotrimeric Gi/o proteins source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/thc-research/32004460.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "928d847ab187a3e3fe459d16f2b1e4068e3378ba613d8122ae49173f03a42c92", "start_char": 0, "end_char": 885, "text_sha256": "928d847ab187a3e3fe459d16f2b1e4068e3378ba613d8122ae49173f03a42c92"}
    experimental_model
    Cryo-electron microscopy of the CB2 receptor bound to heterotrimeric Gi
    exposure
    Agonist-bound receptor coupled to Gi
    limitations
    Captures the active, G-protein-coupled state rather than an antagonist-bound one, which is what makes the coupling claim structural rather than inferred.
    nutrient_topic
    THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
    organism
    Human receptor complex
    plain_language
    The receptor was caught in the act of holding its signalling partner.
    primary_references
    [thc-p32004460] Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex. (2020). https://pubmed.ncbi.nlm.nih.gov/32004460/ DOI: 10.1016/j.cell.2020.01.007
    tissue_or_cell_type
    Purified signalling complex

    THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 140–151

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cryo-electron microscopy of the CB2 receptor bound to heterotrimeric Gi · source_derived_draft · unverified_draft

    ### thc-cb2-gi-structure The cryo-EM structure of the human CB2 receptor in complex with Gi resolved the active-state signalling complex. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: The receptor was caught in the act of holding its signalling partner. organism: Human receptor complex tissue_or_cell_type: Purified signalling complex experimental_model: Cryo-electron microscopy of the CB2 receptor bound to heterotrimeric Gi limitations: Captures the active, G-protein-coupled state rather than an antagonist-bound one, which is what makes the coupling claim structural rather than inferred. exposure: Agonist-bound receptor coupled to Gi evidence_span: {"source_cache": "artifacts/thc-research/32004460.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "928d847ab187a3e3fe459d16f2b1e4068e3378ba613d8122ae49173f03a42c92", "start_char": 0, "end_char": 885, "text_sha256": "928d847ab187a3e3fe459d16f2b1e4068e3378ba613d8122ae49173f03a42c92"} [thc-p32004460] Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex. (2020). https://pubmed.ncbi.nlm.nih.gov/32004460/ DOI: 10.1016/j.cell.2020.01.007
    Complete structured claim and evidence

  2. CB1 and CB2 receptors were characterised for expression and adenylate cyclase modulation within the immune system.

    Human cannabinoid receptor 2 / CB2 / CNR2 → Adenylyl cyclase catalytic activity, model specified source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/thc-research/9070350.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ee1863096eec8d8a18cd47cbc858ebaba4cf13d8bb3b78cd5179e1c1200c130c", "start_char": 0, "end_char": 2231, "text_sha256": "ee1863096eec8d8a18cd47cbc858ebaba4cf13d8bb3b78cd5179e1c1200c130c"}
    experimental_model
    Expression and adenylate cyclase modulation across immune cell populations
    exposure
    Cannabinoid agonists with cAMP measurement
    limitations
    Maps which immune cells carry which receptor. Expression and cAMP modulation are measured; immune function outcomes are not.
    nutrient_topic
    THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
    organism
    Mouse and human immune cells
    plain_language
    Immune cells carry the second receptor and respond through the same messenger.
    primary_references
    [thc-p9070350] Cannabinoid receptors CB1 and CB2: a characterization of expression and adenylate cyclase modulation within the immune system. (1997). https://pubmed.ncbi.nlm.nih.gov/9070350/ DOI: 10.1006/taap.1996.8034
    tissue_or_cell_type
    Immune system

    THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 101–112

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Expression and adenylate cyclase modulation across immune cell populations · source_derived_draft · unverified_draft

    ### thc-cb2-immune CB1 and CB2 receptors were characterised for expression and adenylate cyclase modulation within the immune system. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: Immune cells carry the second receptor and respond through the same messenger. organism: Mouse and human immune cells tissue_or_cell_type: Immune system experimental_model: Expression and adenylate cyclase modulation across immune cell populations limitations: Maps which immune cells carry which receptor. Expression and cAMP modulation are measured; immune function outcomes are not. exposure: Cannabinoid agonists with cAMP measurement evidence_span: {"source_cache": "artifacts/thc-research/9070350.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ee1863096eec8d8a18cd47cbc858ebaba4cf13d8bb3b78cd5179e1c1200c130c", "start_char": 0, "end_char": 2231, "text_sha256": "ee1863096eec8d8a18cd47cbc858ebaba4cf13d8bb3b78cd5179e1c1200c130c"} [thc-p9070350] Cannabinoid receptors CB1 and CB2: a characterization of expression and adenylate cyclase modulation within the immune system. (1997). https://pubmed.ncbi.nlm.nih.gov/9070350/ DOI: 10.1006/taap.1996.8034
    Complete structured claim and evidence

  3. The crystal structure of the human CB2 receptor was determined, showing how its binding pocket differs from that of CB1.

    Human cannabinoid receptor 2 / CB2 / CNR2 → Delta-9-tetrahydrocannabinol / THC source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/thc-research/30639103.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e8e9d44274299ee2844e8fdb56ae1a20709f3fde09ed0ef99ee406a4e46a3c7f", "start_char": 0, "end_char": 1108, "text_sha256": "e8e9d44274299ee2844e8fdb56ae1a20709f3fde09ed0ef99ee406a4e46a3c7f"}
    experimental_model
    X-ray crystallography of the human CB2 receptor
    exposure
    Ligand-bound receptor crystallography
    limitations
    A companion structure for the second receptor, from the same structural programme.
    nutrient_topic
    THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
    organism
    Human receptor
    plain_language
    The two receptors are shaped differently, which is why drugs can prefer one.
    primary_references
    [thc-p30639103] Crystal Structure of the Human Cannabinoid Receptor CB2. (2019). https://pubmed.ncbi.nlm.nih.gov/30639103/ DOI: 10.1016/j.cell.2018.12.011
    tissue_or_cell_type
    Purified receptor

    THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 127–138

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · X-ray crystallography of the human CB2 receptor · source_derived_draft · unverified_draft

    ### thc-cb2-structure The crystal structure of the human CB2 receptor was determined, showing how its binding pocket differs from that of CB1. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: The two receptors are shaped differently, which is why drugs can prefer one. organism: Human receptor tissue_or_cell_type: Purified receptor experimental_model: X-ray crystallography of the human CB2 receptor limitations: A companion structure for the second receptor, from the same structural programme. exposure: Ligand-bound receptor crystallography evidence_span: {"source_cache": "artifacts/thc-research/30639103.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e8e9d44274299ee2844e8fdb56ae1a20709f3fde09ed0ef99ee406a4e46a3c7f", "start_char": 0, "end_char": 1108, "text_sha256": "e8e9d44274299ee2844e8fdb56ae1a20709f3fde09ed0ef99ee406a4e46a3c7f"} [thc-p30639103] Crystal Structure of the Human Cannabinoid Receptor CB2. (2019). https://pubmed.ncbi.nlm.nih.gov/30639103/ DOI: 10.1016/j.cell.2018.12.011
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. The murine CB2 peripheral cannabinoid receptor was cloned, expressed and shown to function as a cannabinoid receptor distinct from the brain receptor.

    Mouse peripheral cannabinoid receptor CB2 / Cnr2 → Delta-9-tetrahydrocannabinol / THC source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/thc-research/8679694.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6140a784856b6848c64e4be175012e45a0c7343fa524308753bee15fc57162d4", "start_char": 0, "end_char": 967, "text_sha256": "6140a784856b6848c64e4be175012e45a0c7343fa524308753bee15fc57162d4"}
    experimental_model
    Cloning, expression and functional characterisation of the murine CB2 receptor
    exposure
    Heterologous expression with ligand binding
    limitations
    Establishes a second, peripheral receptor. It is the mouse orthologue.
    nutrient_topic
    THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
    organism
    Mouse receptor
    plain_language
    A second receptor exists, and it sits mostly outside the brain.
    primary_references
    [thc-p8679694] Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor. (1996). https://pubmed.ncbi.nlm.nih.gov/8679694/ DOI: 10.1016/0167-4781(96)00047-4
    tissue_or_cell_type
    Peripheral and immune tissue

    THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 88–99

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cloning, expression and functional characterisation of the murine CB2 receptor · source_derived_draft · unverified_draft

    ### thc-cb2-cloned The murine CB2 peripheral cannabinoid receptor was cloned, expressed and shown to function as a cannabinoid receptor distinct from the brain receptor. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: A second receptor exists, and it sits mostly outside the brain. organism: Mouse receptor tissue_or_cell_type: Peripheral and immune tissue experimental_model: Cloning, expression and functional characterisation of the murine CB2 receptor limitations: Establishes a second, peripheral receptor. It is the mouse orthologue. exposure: Heterologous expression with ligand binding evidence_span: {"source_cache": "artifacts/thc-research/8679694.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6140a784856b6848c64e4be175012e45a0c7343fa524308753bee15fc57162d4", "start_char": 0, "end_char": 967, "text_sha256": "6140a784856b6848c64e4be175012e45a0c7343fa524308753bee15fc57162d4"} [thc-p8679694] Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor. (1996). https://pubmed.ncbi.nlm.nih.gov/8679694/ DOI: 10.1016/0167-4781(96)00047-4
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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