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Expression and cAMP modulation are measured; immune function outcomes are not.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates.","comparator":null,"unit":null,"notes":"","entity":{"slug":"tetrahydrocannabinol","display_name":"Delta-9-tetrahydrocannabinol / THC","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Mouse and human immune cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Immune cells carry the second receptor and respond through the same messenger.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[thc-p9070350] Cannabinoid receptors CB1 and CB2: a characterization of expression and adenylate cyclase modulation within the immune system. (1997). https://pubmed.ncbi.nlm.nih.gov/9070350/ DOI: 10.1006/taap.1996.8034","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Immune system","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d1d60ab9-f202-5033-a8db-4dbf8b904f68","evidence_kind":"source_excerpt","locator":"Lines 101-112","start_line":101,"end_line":112,"excerpt":"### thc-cb2-immune\nCB1 and CB2 receptors were characterised for expression and adenylate cyclase modulation within the immune system.\nCondition category: normal\nnutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates.\nplain_language: Immune cells carry the second receptor and respond through the same messenger.\norganism: Mouse and human immune cells\ntissue_or_cell_type: Immune system\nexperimental_model: Expression and adenylate cyclase modulation across immune cell populations\nlimitations: Maps which immune cells carry which receptor. Expression and cAMP modulation are measured; immune function outcomes are not.\nexposure: Cannabinoid agonists with cAMP measurement\nevidence_span: {\"source_cache\": \"artifacts/thc-research/9070350.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"ee1863096eec8d8a18cd47cbc858ebaba4cf13d8bb3b78cd5179e1c1200c130c\", \"start_char\": 0, \"end_char\": 2231, \"text_sha256\": \"ee1863096eec8d8a18cd47cbc858ebaba4cf13d8bb3b78cd5179e1c1200c130c\"}\n[thc-p9070350] Cannabinoid receptors CB1 and CB2: a characterization of expression and adenylate cyclase modulation within the immune system. (1997). https://pubmed.ncbi.nlm.nih.gov/9070350/ DOI: 10.1006/taap.1996.8034","model_system":"Expression and adenylate cyclase modulation across immune cell populations","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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