{"id":"5f0264ca-39c5-5408-9dd9-b17ebb05cd23","stable_key":"05a3cf47-e660-5ab3-8c32-5eba9847cf0a:thc-cb2-structure","predicate":"binds","statement":"The crystal structure of the human CB2 receptor was determined, showing how its binding pocket differs from that of CB1.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"93f73c9b-774d-5a77-9a70-78e013173690","mechanism_event_label":"The two receptors are shaped differently, which is why drugs can prefer one.","subject":{"id":"5abfafd4-17c3-587a-8f02-e38cce8f8028","slug":"cnr2","display_name":"Human cannabinoid receptor 2 / CB2 / CNR2","entity_type_key":"protein"},"object":{"id":"5a9e5b75-e6aa-5684-ad62-8a8d60148c84","slug":"tetrahydrocannabinol","display_name":"Delta-9-tetrahydrocannabinol / THC","entity_type_key":"drug"},"evidence_count":1,"mechanism_event":{"id":"93f73c9b-774d-5a77-9a70-78e013173690","stable_key":"05a3cf47-e660-5ab3-8c32-5eba9847cf0a:thc-cb2-structure-event","event_type":"biochemical_relationship","label":"The two receptors are shaped differently, which is why drugs can prefer one.","description":"The crystal structure of the human CB2 receptor was determined, showing how its binding pocket differs from that of CB1.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d092243c-94e9-5f03-a406-2fa245f2f4ae","slug":"cnr1","display_name":"Human cannabinoid receptor 1 / CB1 / CNR1","entity_type_key":"protein"},"role":"compared_receptor","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5abfafd4-17c3-587a-8f02-e38cce8f8028","slug":"cnr2","display_name":"Human cannabinoid receptor 2 / CB2 / CNR2","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5a9e5b75-e6aa-5684-ad62-8a8d60148c84","slug":"tetrahydrocannabinol","display_name":"Delta-9-tetrahydrocannabinol / THC","entity_type_key":"drug"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/thc-research/30639103.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e8e9d44274299ee2844e8fdb56ae1a20709f3fde09ed0ef99ee406a4e46a3c7f\", \"start_char\": 0, \"end_char\": 1108, \"text_sha256\": \"e8e9d44274299ee2844e8fdb56ae1a20709f3fde09ed0ef99ee406a4e46a3c7f\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"X-ray crystallography of the human CB2 receptor","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Ligand-bound receptor crystallography","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A companion structure for the second receptor, from the same structural programme.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates.","comparator":null,"unit":null,"notes":"","entity":{"slug":"tetrahydrocannabinol","display_name":"Delta-9-tetrahydrocannabinol / THC","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human receptor","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The two receptors are shaped differently, which is why drugs can prefer one.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[thc-p30639103] Crystal Structure of the Human Cannabinoid Receptor CB2. (2019). https://pubmed.ncbi.nlm.nih.gov/30639103/ DOI: 10.1016/j.cell.2018.12.011","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Purified receptor","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"11cad7dc-c182-5257-ba7b-9ea0af31fa75","evidence_kind":"source_excerpt","locator":"Lines 127-138","start_line":127,"end_line":138,"excerpt":"### thc-cb2-structure\nThe crystal structure of the human CB2 receptor was determined, showing how its binding pocket differs from that of CB1.\nCondition category: normal\nnutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates.\nplain_language: The two receptors are shaped differently, which is why drugs can prefer one.\norganism: Human receptor\ntissue_or_cell_type: Purified receptor\nexperimental_model: X-ray crystallography of the human CB2 receptor\nlimitations: A companion structure for the second receptor, from the same structural programme.\nexposure: Ligand-bound receptor crystallography\nevidence_span: {\"source_cache\": \"artifacts/thc-research/30639103.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e8e9d44274299ee2844e8fdb56ae1a20709f3fde09ed0ef99ee406a4e46a3c7f\", \"start_char\": 0, \"end_char\": 1108, \"text_sha256\": \"e8e9d44274299ee2844e8fdb56ae1a20709f3fde09ed0ef99ee406a4e46a3c7f\"}\n[thc-p30639103] Crystal Structure of the Human Cannabinoid Receptor CB2. (2019). https://pubmed.ncbi.nlm.nih.gov/30639103/ DOI: 10.1016/j.cell.2018.12.011","model_system":"X-ray crystallography of the human CB2 receptor","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [thc-p30639103] Crystal Structure of the Human Cannabinoid Receptor CB2. (2019). https://pubmed.ncbi.nlm.nih.gov/30639103/ DOI: 10.1016/j.cell.2018.12.011","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b4367320-9724-507a-bead-6932fa0a78cb","stable_key":"import-05a3cf47-e660-5ab3-8c32-5eba9847cf0a","title":"THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"60abc81737d18b7a50b01ca487e38291774ee15d9777651aa2d3eac8670ac3b2","revision_id":"2cba3552-af89-580d-b20a-8cfb1b14f9e7","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}