Component

Circulating hepcidin concentration

Circulating hepcidin concentration. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Hepcidin did not change significantly in this trial.

    Curcumin → Circulating hepcidin concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/curcumin-research/29806132.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d000b66ecff021e755bef4a69beb4e1699039b55f1af96844c7860bae4b1847c", "start_char": 0, "end_char": 1511, "text_sha256": "d000b66ecff021e755bef4a69beb4e1699039b55f1af96844c7860bae4b1847c"}
    experimental_model
    Double-blind randomized trial in 68 beta-thalassemia major patients
    exposure
    Two 500-mg capsules per day, total 1000 mg/day, for 12 weeks; placebo comparison
    limitations
    Disease-specific adjunctive experiment. Lower NTBI is not proof that standard chelation can be replaced or that hepcidin mediates the change.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Homo sapiens
    plain_language
    The human marker result did not establish hepcidin suppression.
    primary_references
    [curcumin-p29806132] An investigation of the effects of curcumin on iron overload, hepcidin level, and liver function in β-thalassemia major patients: A double-blind randomized controlled clinical trial. (2018). https://pubmed.ncbi.nlm.nih.gov/29806132/ DOI: 10.1002/ptr.6118
    tissue_or_cell_type
    Circulating iron markers

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 762–773

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind randomized trial in 68 beta-thalassemia major patients · source_derived_draft · unverified_draft

    ### curcumin-thal-hepcidin-null Hepcidin did not change significantly in this trial. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The human marker result did not establish hepcidin suppression. organism: Homo sapiens tissue_or_cell_type: Circulating iron markers experimental_model: Double-blind randomized trial in 68 beta-thalassemia major patients limitations: Disease-specific adjunctive experiment. Lower NTBI is not proof that standard chelation can be replaced or that hepcidin mediates the change. exposure: Two 500-mg capsules per day, total 1000 mg/day, for 12 weeks; placebo comparison evidence_span: {"source_cache": "artifacts/curcumin-research/29806132.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d000b66ecff021e755bef4a69beb4e1699039b55f1af96844c7860bae4b1847c", "start_char": 0, "end_char": 1511, "text_sha256": "d000b66ecff021e755bef4a69beb4e1699039b55f1af96844c7860bae4b1847c"} [curcumin-p29806132] An investigation of the effects of curcumin on iron overload, hepcidin level, and liver function in β-thalassemia major patients: A double-blind randomized controlled clinical trial. (2018). https://pubmed.ncbi.nlm.nih.gov/29806132/ DOI: 10.1002/ptr.6118
    Complete structured claim and evidence

  2. Doses of at least 60 mg raised hepcidin at 24 hours and reduced fractional absorption of subsequent iron by 35–45%.

    Ferrous sulfate → Circulating hepcidin concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/iron-research/26289639.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "67eb8d47c0df5398c03a2a73fdd7698efc0467e85db72cfdcc829fab72b90096", "start_char": 0, "end_char": 1708, "text_sha256": "67eb8d47c0df5398c03a2a73fdd7698efc0467e85db72cfdcc829fab72b90096"}
    experimental_model
    Stable-isotope dose studies
    exposure
    40–240 mg oral labeled ferrous sulfate; successive or twice-daily doses
    limitations
    Short-term fractional absorption is not equivalent to long-term hemoglobin recovery; dose values describe the experiment.
    nutrient_topic
    Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
    organism
    54 nonanemic iron-depleted young women
    plain_language
    An iron dose can temporarily make the next dose harder to absorb.
    primary_references
    [iron-p26289639] Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young women. (2015). https://pubmed.ncbi.nlm.nih.gov/26289639/ DOI: 10.1182/blood-2015-05-642223
    tissue_or_cell_type
    Iron absorption and circulating hepcidin

    Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 1278–1289

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Stable-isotope dose studies · source_derived_draft · unverified_draft

    ### iron-oral-iron-hepcidin Doses of at least 60 mg raised hepcidin at 24 hours and reduced fractional absorption of subsequent iron by 35–45%. Condition category: normal nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: An iron dose can temporarily make the next dose harder to absorb. organism: 54 nonanemic iron-depleted young women tissue_or_cell_type: Iron absorption and circulating hepcidin experimental_model: Stable-isotope dose studies limitations: Short-term fractional absorption is not equivalent to long-term hemoglobin recovery; dose values describe the experiment. exposure: 40–240 mg oral labeled ferrous sulfate; successive or twice-daily doses evidence_span: {"source_cache": "artifacts/iron-research/26289639.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "67eb8d47c0df5398c03a2a73fdd7698efc0467e85db72cfdcc829fab72b90096", "start_char": 0, "end_char": 1708, "text_sha256": "67eb8d47c0df5398c03a2a73fdd7698efc0467e85db72cfdcc829fab72b90096"} [iron-p26289639] Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young women. (2015). https://pubmed.ncbi.nlm.nih.gov/26289639/ DOI: 10.1182/blood-2015-05-642223
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. CRP, hepcidin, midkine and IL-8 increased during prolonged fasting.

    Fasting / abstention from energy intake → Acute inflammatory markers during prolonged fasting source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Twenty adults; supervised water fast averaging 9.8 days, then guided refeeding.
    limitations
    Not proof that every fast increases inflammation; cellular NLRP3 results measure something different.
    nutrient_topic
    Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished. · Fasting / abstention from energy intake
    plain_language
    Whole-body inflammatory measurements did not simply follow the anti-inflammatory ketone story.
    primary_references
    Prolonged fasting promotes systemic inflammation and platelet activation in humans: A medically supervised, water-only fasting and refeeding study. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40268190/ · DOI 10.1016/j.molmet.2025.102152

    Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18) · lines 432–438

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Twenty adults; supervised water fast averaging 9.8 days, then guided refeeding. · source_derived_draft · unverified_draft

    ## fast-inflammation Whole-body inflammatory measurements did not simply follow the anti-inflammatory ketone story. CRP, hepcidin, midkine and IL-8 increased during prolonged fasting. Model: Twenty adults; supervised water fast averaging 9.8 days, then guided refeeding. Limitations: Not proof that every fast increases inflammation; cellular NLRP3 results measure something different. Evidence access: Primary abstract Prolonged fasting promotes systemic inflammation and platelet activation in humans: A medically supervised, water-only fasting and refeeding study. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40268190/ · DOI 10.1016/j.molmet.2025.102152
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards