{"id":"ac9437af-cd26-5ab1-b28f-e88803bf851d","stable_key":"53d9b98d-e3a0-5416-bc88-adbe42a8cb1b:curcumin-thal-hepcidin-null","predicate":"did_not_significantly_change","statement":"Hepcidin did not change significantly in this trial.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8775ee81-978a-5799-9ed6-add4cc3a1409","mechanism_event_label":"The human marker result did not establish hepcidin suppression.","subject":{"id":"0e625439-d093-5d1b-8713-dcfdafcf6811","slug":"curcumin","display_name":"Curcumin","entity_type_key":"small_molecule"},"object":{"id":"398677e5-b00a-5d07-bffb-cb4b42ba9f87","slug":"circulating-hepcidin-concentration","display_name":"Circulating hepcidin concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8775ee81-978a-5799-9ed6-add4cc3a1409","stable_key":"53d9b98d-e3a0-5416-bc88-adbe42a8cb1b:curcumin-thal-hepcidin-null-event","event_type":"observed_intervention","label":"The human marker result did not establish hepcidin suppression.","description":"Hepcidin did not change significantly in this trial.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0e625439-d093-5d1b-8713-dcfdafcf6811","slug":"curcumin","display_name":"Curcumin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"398677e5-b00a-5d07-bffb-cb4b42ba9f87","slug":"circulating-hepcidin-concentration","display_name":"Circulating hepcidin concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/curcumin-research/29806132.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d000b66ecff021e755bef4a69beb4e1699039b55f1af96844c7860bae4b1847c\", \"start_char\": 0, \"end_char\": 1511, \"text_sha256\": \"d000b66ecff021e755bef4a69beb4e1699039b55f1af96844c7860bae4b1847c\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Double-blind randomized trial in 68 beta-thalassemia major patients","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Two 500-mg capsules per day, total 1000 mg/day, for 12 weeks; placebo comparison","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Disease-specific adjunctive experiment. 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Lower NTBI is not proof that standard chelation can be replaced or that hepcidin mediates the change.\nexposure: Two 500-mg capsules per day, total 1000 mg/day, for 12 weeks; placebo comparison\nevidence_span: {\"source_cache\": \"artifacts/curcumin-research/29806132.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d000b66ecff021e755bef4a69beb4e1699039b55f1af96844c7860bae4b1847c\", \"start_char\": 0, \"end_char\": 1511, \"text_sha256\": \"d000b66ecff021e755bef4a69beb4e1699039b55f1af96844c7860bae4b1847c\"}\n[curcumin-p29806132] An investigation of the effects of curcumin on iron overload, hepcidin level, and liver function in β-thalassemia major patients: A double-blind randomized controlled clinical trial. 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