{"id":"98a871c2-0101-5b8d-8b1b-a37f3a9a4e02","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-inflammation","predicate":"increases_in_protocol","statement":"CRP, hepcidin, midkine and IL-8 increased during prolonged fasting.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"518e966e-572b-5180-8bc8-59f0fcffd22e","mechanism_event_label":"Whole-body inflammatory measurements did not simply follow the anti-inflammatory ketone story.","subject":{"id":"2d5df4b9-44d7-56a5-8ecf-7c08c0ae9f4f","slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"},"object":{"id":"4fcc319b-f86d-5bb5-b92b-5ec68d86a0d8","slug":"fasting-acute-inflammatory-response","display_name":"Acute inflammatory markers during prolonged fasting","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"518e966e-572b-5180-8bc8-59f0fcffd22e","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-inflammation-event","event_type":"observed_relationship","label":"Whole-body inflammatory measurements did not simply follow the anti-inflammatory ketone story.","description":"CRP, hepcidin, midkine and IL-8 increased during prolonged fasting.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2d5df4b9-44d7-56a5-8ecf-7c08c0ae9f4f","slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4fcc319b-f86d-5bb5-b92b-5ec68d86a0d8","slug":"fasting-acute-inflammatory-response","display_name":"Acute inflammatory markers during prolonged fasting","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"398677e5-b00a-5d07-bffb-cb4b42ba9f87","slug":"circulating-hepcidin-concentration","display_name":"Circulating hepcidin concentration","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Twenty adults; supervised water fast averaging 9.8 days, then guided refeeding.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not proof that every fast increases inflammation; cellular NLRP3 results measure something different.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"Whole-body inflammatory measurements did not simply follow the anti-inflammatory ketone story.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Prolonged fasting promotes systemic inflammation and platelet activation in humans: A medically supervised, water-only fasting and refeeding study. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40268190/ · DOI 10.1016/j.molmet.2025.102152","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"fbf4b968-c837-553a-8181-cb80fd2e1778","evidence_kind":"source_excerpt","locator":"Lines 432-438","start_line":432,"end_line":438,"excerpt":"## fast-inflammation\nWhole-body inflammatory measurements did not simply follow the anti-inflammatory ketone story.\nCRP, hepcidin, midkine and IL-8 increased during prolonged fasting.\nModel: Twenty adults; supervised water fast averaging 9.8 days, then guided refeeding.\nLimitations: Not proof that every fast increases inflammation; cellular NLRP3 results measure something different.\nEvidence access: Primary abstract\nProlonged fasting promotes systemic inflammation and platelet activation in humans: A medically supervised, water-only fasting and refeeding study. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40268190/ · DOI 10.1016/j.molmet.2025.102152","model_system":"Twenty adults; supervised water fast averaging 9.8 days, then guided refeeding.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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