Component

Circulating estradiol concentration

Circulating estradiol concentration. Species, exposure and limitations are retained in each linked claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Boron supplementation increased circulating 17β-estradiol in the 1987 postmenopausal feeding study, with an apparently larger response when dietary magnesium was low.

    Boron → Circulating estradiol concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/boron-research/3678698.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8f95ac01b63502b366e2bd79785b7203deb793d258df065f13cc1e0123c89fb7", "start_char": 0, "end_char": 1373, "text_sha256": "8f95ac01b63502b366e2bd79785b7203deb793d258df065f13cc1e0123c89fb7"}
    experimental_model
    Sequential controlled feeding in a metabolic unit; 12 postmenopausal women
    exposure
    About 0.25 mg boron/day for 119 days, then 3 mg/day supplement; seven low-magnesium and five adequate-magnesium participants
    limitations
    Small sequential study, not a fracture or bone-density trial. Diet and magnesium status matter. Later studies did not consistently reproduce the reported effects.
    nutrient_topic
    Boron research collection; topical membership is not evidence of a direct dietary effect. · Boron
    organism
    Human
    plain_language
    A hormone measurement rose in this small study; later findings do not support a reliable hormone-boosting rule.
    primary_references
    [boron-p3678698] Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. (1987). https://pubmed.ncbi.nlm.nih.gov/3678698/ DOI: 10.1096/fasebj.1.5.3678698
    tissue_or_cell_type
    Systemic mineral balance and circulating hormones
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17) · lines 638–649

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Sequential controlled feeding in a metabolic unit; 12 postmenopausal women · source_derived_draft · unverified_draft

    ### boron-estradiol-1987 Boron supplementation increased circulating 17β-estradiol in the 1987 postmenopausal feeding study, with an apparently larger response when dietary magnesium was low. Condition category: nutrient_deficiency nutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect. plain_language: A hormone measurement rose in this small study; later findings do not support a reliable hormone-boosting rule. organism: Human tissue_or_cell_type: Systemic mineral balance and circulating hormones experimental_model: Sequential controlled feeding in a metabolic unit; 12 postmenopausal women limitations: Small sequential study, not a fracture or bone-density trial. Diet and magnesium status matter. Later studies did not consistently reproduce the reported effects. exposure: About 0.25 mg boron/day for 119 days, then 3 mg/day supplement; seven low-magnesium and five adequate-magnesium participants evidence_span: {"source_cache": "artifacts/boron-research/3678698.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8f95ac01b63502b366e2bd79785b7203deb793d258df065f13cc1e0123c89fb7", "start_char": 0, "end_char": 1373, "text_sha256": "8f95ac01b63502b366e2bd79785b7203deb793d258df065f13cc1e0123c89fb7"} [boron-p3678698] Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. (1987). https://pubmed.ncbi.nlm.nih.gov/3678698/ DOI: 10.1096/fasebj.1.5.3678698
    Complete structured claim and evidence

  2. Boron supplementation decreased serum 17β-estradiol when dietary magnesium was low in the 2004 study.

    Boron → Circulating estradiol concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/boron-research/15724868.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7009311021e781ba9b1e9a9244c081cf20700511cc8704e8294b1a2c55dc0e24", "start_char": 0, "end_char": 2138, "text_sha256": "7009311021e781ba9b1e9a9244c081cf20700511cc8704e8294b1a2c55dc0e24"}
    experimental_model
    Double-blind Latin-square metabolic-unit feeding in 13 postmenopausal women
    exposure
    Approximately 118 versus 318 mg Mg/day and 0.25 versus 3.25 mg B/day; 42-day periods
    limitations
    Boron had no obvious overall effect on the response to magnesium deprivation. Results cannot establish boron as a treatment for hypomagnesemia or a substitute for magnesium.
    nutrient_topic
    Boron research collection; topical membership is not evidence of a direct dietary effect. · Boron
    organism
    Human
    plain_language
    Under this low-magnesium regimen the hormone response went downward.
    primary_references
    [boron-p15724868] The alteration of magnesium, calcium and phosphorus metabolism by dietary magnesium deprivation in postmenopausal women is not affected by dietary boron deprivation. (2004). https://pubmed.ncbi.nlm.nih.gov/15724868/
    tissue_or_cell_type
    Mineral balance and endocrine measurements
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17) · lines 755–766

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind Latin-square metabolic-unit feeding in 13 postmenopausal women · source_derived_draft · unverified_draft

    ### boron-estradiol-low-mg-2004 Boron supplementation decreased serum 17β-estradiol when dietary magnesium was low in the 2004 study. Condition category: nutrient_deficiency nutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect. plain_language: Under this low-magnesium regimen the hormone response went downward. organism: Human tissue_or_cell_type: Mineral balance and endocrine measurements experimental_model: Double-blind Latin-square metabolic-unit feeding in 13 postmenopausal women limitations: Boron had no obvious overall effect on the response to magnesium deprivation. Results cannot establish boron as a treatment for hypomagnesemia or a substitute for magnesium. exposure: Approximately 118 versus 318 mg Mg/day and 0.25 versus 3.25 mg B/day; 42-day periods evidence_span: {"source_cache": "artifacts/boron-research/15724868.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7009311021e781ba9b1e9a9244c081cf20700511cc8704e8294b1a2c55dc0e24", "start_char": 0, "end_char": 2138, "text_sha256": "7009311021e781ba9b1e9a9244c081cf20700511cc8704e8294b1a2c55dc0e24"} [boron-p15724868] The alteration of magnesium, calcium and phosphorus metabolism by dietary magnesium deprivation in postmenopausal women is not affected by dietary boron deprivation. (2004). https://pubmed.ncbi.nlm.nih.gov/15724868/
    Complete structured claim and evidence

  3. The 1993 low-boron/supplementation study found no effect of the added boron on measured plasma sex steroids.

    Boron → Circulating estradiol concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/boron-research/8329361.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3e6e2137f75699ea6dce582375f335a85139fea1cfa7ec502f033e8bfe026d63", "start_char": 0, "end_char": 1079, "text_sha256": "3e6e2137f75699ea6dce582375f335a85139fea1cfa7ec502f033e8bfe026d63"}
    experimental_model
    Metabolic-unit low-intake/supplementation follow-up
    exposure
    0.33 mg boron/day for three weeks, then an additional 3 mg/day for three weeks
    limitations
    Small, short sequential study. The background diet produced positive calcium balance with increased urinary calcium; the authors proposed that this could mask a boron effect, but did not prove the explanation.
    nutrient_topic
    Boron research collection; topical membership is not evidence of a direct dietary effect. · Boron
    organism
    Human postmenopausal volunteers
    plain_language
    The earlier hormone rise was not reproduced under this shorter regimen.
    primary_references
    [boron-p8329361] The influence of a low-boron diet and boron supplementation on bone, major mineral and sex steroid metabolism in postmenopausal women. (1993). https://pubmed.ncbi.nlm.nih.gov/8329361/ DOI: 10.1079/bjn19930087
    tissue_or_cell_type
    Mineral balance, hormones and bone-turnover markers
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17) · lines 716–727

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Metabolic-unit low-intake/supplementation follow-up · source_derived_draft · unverified_draft

    ### boron-human-estradiol-null-1993 The 1993 low-boron/supplementation study found no effect of the added boron on measured plasma sex steroids. Condition category: nutrient_deficiency nutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect. plain_language: The earlier hormone rise was not reproduced under this shorter regimen. organism: Human postmenopausal volunteers tissue_or_cell_type: Mineral balance, hormones and bone-turnover markers experimental_model: Metabolic-unit low-intake/supplementation follow-up limitations: Small, short sequential study. The background diet produced positive calcium balance with increased urinary calcium; the authors proposed that this could mask a boron effect, but did not prove the explanation. exposure: 0.33 mg boron/day for three weeks, then an additional 3 mg/day for three weeks evidence_span: {"source_cache": "artifacts/boron-research/8329361.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3e6e2137f75699ea6dce582375f335a85139fea1cfa7ec502f033e8bfe026d63", "start_char": 0, "end_char": 1079, "text_sha256": "3e6e2137f75699ea6dce582375f335a85139fea1cfa7ec502f033e8bfe026d63"} [boron-p8329361] The influence of a low-boron diet and boron supplementation on bone, major mineral and sex steroid metabolism in postmenopausal women. (1993). https://pubmed.ncbi.nlm.nih.gov/8329361/ DOI: 10.1079/bjn19930087
    Complete structured claim and evidence

  4. Mean estradiol decreased at the one-week morning measurement in the eight-man supplementation study.

    Boron → Circulating estradiol concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/boron-research/21129941.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157", "start_char": 0, "end_char": 1706, "text_sha256": "4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157"}
    experimental_model
    Sequential placebo-day and supplementation observations in eight men
    exposure
    10 mg boron/day for one week; acute six-hour and day-seven measurements
    limitations
    Eight participants without a randomized parallel control. Time effects, short duration and multiple endpoints limit causal and clinical interpretation. Lower SHBG does not demonstrate direct boron binding to SHBG.
    nutrient_topic
    Boron research collection; topical membership is not evidence of a direct dietary effect. · Boron
    organism
    Human healthy male volunteers
    plain_language
    The hormone response differed from the earlier postmenopausal result.
    primary_references
    [boron-p21129941] Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. (2011). https://pubmed.ncbi.nlm.nih.gov/21129941/ DOI: 10.1016/j.jtemb.2010.10.001
    tissue_or_cell_type
    Plasma hormones and inflammatory biomarkers

    Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17) · lines 1028–1039

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Sequential placebo-day and supplementation observations in eight men · source_derived_draft · unverified_draft

    ### boron-short-study-estradiol Mean estradiol decreased at the one-week morning measurement in the eight-man supplementation study. Condition category: normal nutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect. plain_language: The hormone response differed from the earlier postmenopausal result. organism: Human healthy male volunteers tissue_or_cell_type: Plasma hormones and inflammatory biomarkers experimental_model: Sequential placebo-day and supplementation observations in eight men limitations: Eight participants without a randomized parallel control. Time effects, short duration and multiple endpoints limit causal and clinical interpretation. Lower SHBG does not demonstrate direct boron binding to SHBG. exposure: 10 mg boron/day for one week; acute six-hour and day-seven measurements evidence_span: {"source_cache": "artifacts/boron-research/21129941.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157", "start_char": 0, "end_char": 1706, "text_sha256": "4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157"} [boron-p21129941] Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. (2011). https://pubmed.ncbi.nlm.nih.gov/21129941/ DOI: 10.1016/j.jtemb.2010.10.001
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

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