{"id":"096b34b8-192b-5e61-a711-ed41bc1f58a0","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-human-estradiol-null-1993","predicate":"did_not_change","statement":"The 1993 low-boron/supplementation study found no effect of the added boron on measured plasma sex steroids.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8b8690e6-e5e3-59ca-a416-c5ba34e7fb6d","mechanism_event_label":"The earlier hormone rise was not reproduced under this shorter regimen.","subject":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"object":{"id":"b742e57b-3d1f-535f-825b-03a4183596a9","slug":"circulating-estradiol","display_name":"Circulating estradiol concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8b8690e6-e5e3-59ca-a416-c5ba34e7fb6d","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-human-estradiol-null-1993-event","event_type":"observed_intervention","label":"The earlier hormone rise was not reproduced under this shorter regimen.","description":"The 1993 low-boron/supplementation study found no effect of the added boron on measured plasma sex steroids.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dffa79cf-8fea-51e0-8839-6ca30a81cd6a","slug":"circulating-total-testosterone","display_name":"Circulating total testosterone concentration","entity_type_key":"cellular_process"},"role":"measured_endpoint","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b742e57b-3d1f-535f-825b-03a4183596a9","slug":"circulating-estradiol","display_name":"Circulating estradiol concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/boron-research/8329361.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3e6e2137f75699ea6dce582375f335a85139fea1cfa7ec502f033e8bfe026d63\", \"start_char\": 0, \"end_char\": 1079, \"text_sha256\": \"3e6e2137f75699ea6dce582375f335a85139fea1cfa7ec502f033e8bfe026d63\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Metabolic-unit low-intake/supplementation follow-up","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"0.33 mg boron/day for three weeks, then an additional 3 mg/day for three weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small, short sequential study. The background diet produced positive calcium balance with increased urinary calcium; the authors proposed that this could mask a boron effect, but did not prove the explanation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Boron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human postmenopausal volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The earlier hormone rise was not reproduced under this shorter regimen.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[boron-p8329361] The influence of a low-boron diet and boron supplementation on bone, major mineral and sex steroid metabolism in postmenopausal women. (1993). https://pubmed.ncbi.nlm.nih.gov/8329361/ DOI: 10.1079/bjn19930087","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Mineral balance, hormones and bone-turnover markers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"b9abbd19-137c-5d8d-b36b-0417ca24df0b","evidence_kind":"source_excerpt","locator":"Lines 716-727","start_line":716,"end_line":727,"excerpt":"### boron-human-estradiol-null-1993\nThe 1993 low-boron/supplementation study found no effect of the added boron on measured plasma sex steroids.\nCondition category: nutrient_deficiency\nnutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The earlier hormone rise was not reproduced under this shorter regimen.\norganism: Human postmenopausal volunteers\ntissue_or_cell_type: Mineral balance, hormones and bone-turnover markers\nexperimental_model: Metabolic-unit low-intake/supplementation follow-up\nlimitations: Small, short sequential study. The background diet produced positive calcium balance with increased urinary calcium; the authors proposed that this could mask a boron effect, but did not prove the explanation.\nexposure: 0.33 mg boron/day for three weeks, then an additional 3 mg/day for three weeks\nevidence_span: {\"source_cache\": \"artifacts/boron-research/8329361.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3e6e2137f75699ea6dce582375f335a85139fea1cfa7ec502f033e8bfe026d63\", \"start_char\": 0, \"end_char\": 1079, \"text_sha256\": \"3e6e2137f75699ea6dce582375f335a85139fea1cfa7ec502f033e8bfe026d63\"}\n[boron-p8329361] The influence of a low-boron diet and boron supplementation on bone, major mineral and sex steroid metabolism in postmenopausal women. (1993). https://pubmed.ncbi.nlm.nih.gov/8329361/ DOI: 10.1079/bjn19930087","model_system":"Metabolic-unit low-intake/supplementation follow-up","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [boron-p8329361] The influence of a low-boron diet and boron supplementation on bone, major mineral and sex steroid metabolism in postmenopausal women. (1993). https://pubmed.ncbi.nlm.nih.gov/8329361/ DOI: 10.1079/bjn19930087","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2d96c547-aeec-5d8b-9d31-1288da209f89","stable_key":"import-7edf94bb-95c8-5234-9161-9eb338bb9b36","title":"Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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