{"id":"c1a5e012-a014-57d1-b269-a872388901f2","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-short-study-estradiol","predicate":"reduces","statement":"Mean estradiol decreased at the one-week morning measurement in the eight-man supplementation study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"4009287e-e8f9-5e44-b222-690e530d8db7","mechanism_event_label":"The hormone response differed from the earlier postmenopausal result.","subject":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"object":{"id":"b742e57b-3d1f-535f-825b-03a4183596a9","slug":"circulating-estradiol","display_name":"Circulating estradiol concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4009287e-e8f9-5e44-b222-690e530d8db7","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-short-study-estradiol-event","event_type":"observed_intervention","label":"The hormone response differed from the earlier postmenopausal result.","description":"Mean estradiol decreased at the one-week morning measurement in the eight-man supplementation study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b742e57b-3d1f-535f-825b-03a4183596a9","slug":"circulating-estradiol","display_name":"Circulating estradiol concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/boron-research/21129941.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157\", \"start_char\": 0, \"end_char\": 1706, \"text_sha256\": \"4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Sequential placebo-day and supplementation observations in eight men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"10 mg boron/day for one week; acute six-hour and day-seven measurements","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Eight participants without a randomized parallel control. Time effects, short duration and multiple endpoints limit causal and clinical interpretation. Lower SHBG does not demonstrate direct boron binding to SHBG.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Boron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human healthy male volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The hormone response differed from the earlier postmenopausal result.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[boron-p21129941] Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. (2011). https://pubmed.ncbi.nlm.nih.gov/21129941/ DOI: 10.1016/j.jtemb.2010.10.001","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma hormones and inflammatory biomarkers","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"902f6d27-88a6-590c-ac0f-d242e93cfb27","evidence_kind":"source_excerpt","locator":"Lines 1028-1039","start_line":1028,"end_line":1039,"excerpt":"### boron-short-study-estradiol\nMean estradiol decreased at the one-week morning measurement in the eight-man supplementation study.\nCondition category: normal\nnutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The hormone response differed from the earlier postmenopausal result.\norganism: Human healthy male volunteers\ntissue_or_cell_type: Plasma hormones and inflammatory biomarkers\nexperimental_model: Sequential placebo-day and supplementation observations in eight men\nlimitations: Eight participants without a randomized parallel control. Time effects, short duration and multiple endpoints limit causal and clinical interpretation. Lower SHBG does not demonstrate direct boron binding to SHBG.\nexposure: 10 mg boron/day for one week; acute six-hour and day-seven measurements\nevidence_span: {\"source_cache\": \"artifacts/boron-research/21129941.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157\", \"start_char\": 0, \"end_char\": 1706, \"text_sha256\": \"4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157\"}\n[boron-p21129941] Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. 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