Component

Circulating boron concentration

Circulating boron concentration. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. A ninefold difference in dietary boron produced only a 1.5-fold difference in plasma boron; fecal plus urinary excretion accounted for almost all intake without progressive accumulation.

    Boron → Circulating boron concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/boron-research/9062533.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a23cd1fe09277bdd83b690746d4bbaf4742cdd74e51d5b27ee898bd87208b2be", "start_char": 0, "end_char": 1720, "text_sha256": "a23cd1fe09277bdd83b690746d4bbaf4742cdd74e51d5b27ee898bd87208b2be"}
    experimental_model
    Metabolic-ward feeding; 11 postmenopausal volunteers
    exposure
    167-day study; basal 0.36 mg B and 109 mg Mg/8400 kJ; 3 mg/day B supplement in last two 24-day periods; magnesium supplement 0 or 200 mg/day
    limitations
    Small study with multiple dietary periods and supplements. Do not assume independence from related reports from the same research program. Urine composition is not a kidney-stone clinical endpoint.
    nutrient_topic
    Boron research collection; topical membership is not evidence of a direct dietary effect. · Boron
    organism
    Human
    plain_language
    Blood boron did not rise in proportion to intake because the body eliminated much of the exposure.
    primary_references
    [boron-p9062533] Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations. (1997). https://pubmed.ncbi.nlm.nih.gov/9062533/ DOI: 10.1093/ajcn/65.3.803
    tissue_or_cell_type
    Mineral balance, blood and excreta

    Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17) · lines 690–701

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Metabolic-ward feeding; 11 postmenopausal volunteers · source_derived_draft · unverified_draft

    ### boron-feeding-boron-homeostasis A ninefold difference in dietary boron produced only a 1.5-fold difference in plasma boron; fecal plus urinary excretion accounted for almost all intake without progressive accumulation. Condition category: normal nutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect. plain_language: Blood boron did not rise in proportion to intake because the body eliminated much of the exposure. organism: Human tissue_or_cell_type: Mineral balance, blood and excreta experimental_model: Metabolic-ward feeding; 11 postmenopausal volunteers limitations: Small study with multiple dietary periods and supplements. Do not assume independence from related reports from the same research program. Urine composition is not a kidney-stone clinical endpoint. exposure: 167-day study; basal 0.36 mg B and 109 mg Mg/8400 kJ; 3 mg/day B supplement in last two 24-day periods; magnesium supplement 0 or 200 mg/day evidence_span: {"source_cache": "artifacts/boron-research/9062533.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a23cd1fe09277bdd83b690746d4bbaf4742cdd74e51d5b27ee898bd87208b2be", "start_char": 0, "end_char": 1720, "text_sha256": "a23cd1fe09277bdd83b690746d4bbaf4742cdd74e51d5b27ee898bd87208b2be"} [boron-p9062533] Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations. (1997). https://pubmed.ncbi.nlm.nih.gov/9062533/ DOI: 10.1093/ajcn/65.3.803
    Complete structured claim and evidence

  2. The fitted terminal boric-acid half-life was 21.0 ± 4.9 hours and total clearance 54.6 ± 8.0 mL/min/1.73 m² in the intravenous study.

    Boric acid / orthoboric acid / B(OH)3 → Circulating boron concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/boron-research/6732506.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7deee2df94fd1ab9d173e7ddf97660bd8402d51bed8ac2bb8cac8810be66ca61", "start_char": 0, "end_char": 652, "text_sha256": "7deee2df94fd1ab9d173e7ddf97660bd8402d51bed8ac2bb8cac8810be66ca61"}
    experimental_model
    Single-dose intravenous pharmacokinetics in eight adult men
    exposure
    562–611 mg boric acid over 20 minutes; plasma followed three days and urine 120 hours
    limitations
    Historical intravenous experimental exposure is not an oral supplement regimen. These kinetics should not be generalized to kidney impairment or every exposure route.
    nutrient_topic
    Boron research collection; topical membership is not evidence of a direct dietary effect. · Boron
    organism
    Human
    plain_language
    The measured blood level reflected elimination over roughly a day, with variation among participants.
    primary_references
    [boron-p6732506] Boric acid single dose pharmacokinetics after intravenous administration to man. (1984). https://pubmed.ncbi.nlm.nih.gov/6732506/ DOI: 10.1007/bf00316588
    tissue_or_cell_type
    Plasma and urine; six participants included in compartment fitting

    Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17) · lines 1106–1117

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Single-dose intravenous pharmacokinetics in eight adult men · source_derived_draft · unverified_draft

    ### boron-plasma-kinetics The fitted terminal boric-acid half-life was 21.0 ± 4.9 hours and total clearance 54.6 ± 8.0 mL/min/1.73 m² in the intravenous study. Condition category: normal nutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect. plain_language: The measured blood level reflected elimination over roughly a day, with variation among participants. organism: Human tissue_or_cell_type: Plasma and urine; six participants included in compartment fitting experimental_model: Single-dose intravenous pharmacokinetics in eight adult men limitations: Historical intravenous experimental exposure is not an oral supplement regimen. These kinetics should not be generalized to kidney impairment or every exposure route. exposure: 562–611 mg boric acid over 20 minutes; plasma followed three days and urine 120 hours evidence_span: {"source_cache": "artifacts/boron-research/6732506.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7deee2df94fd1ab9d173e7ddf97660bd8402d51bed8ac2bb8cac8810be66ca61", "start_char": 0, "end_char": 652, "text_sha256": "7deee2df94fd1ab9d173e7ddf97660bd8402d51bed8ac2bb8cac8810be66ca61"} [boron-p6732506] Boric acid single dose pharmacokinetics after intravenous administration to man. (1984). https://pubmed.ncbi.nlm.nih.gov/6732506/ DOI: 10.1007/bf00316588
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards