{"id":"76a40983-d6ad-514c-adf1-deadf88cfbf1","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-plasma-kinetics","predicate":"modulates","statement":"The fitted terminal boric-acid half-life was 21.0 ± 4.9 hours and total clearance 54.6 ± 8.0 mL/min/1.73 m² in the intravenous study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c44715d0-3dca-5345-8183-4063d6b191ea","mechanism_event_label":"The measured blood level reflected elimination over roughly a day, with variation among participants.","subject":{"id":"56db2f3c-f247-573f-bb7c-47cac02ea60f","slug":"boric-acid","display_name":"Boric acid / orthoboric acid / B(OH)3","entity_type_key":"small_molecule"},"object":{"id":"4ff95f93-b0fa-5a20-8c40-0b65e78a768d","slug":"circulating-boron-concentration","display_name":"Circulating boron concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c44715d0-3dca-5345-8183-4063d6b191ea","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-plasma-kinetics-event","event_type":"observed_intervention","label":"The measured blood level reflected elimination over roughly a day, with variation among participants.","description":"The fitted terminal boric-acid half-life was 21.0 ± 4.9 hours and total clearance 54.6 ± 8.0 mL/min/1.73 m² in the intravenous study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"56db2f3c-f247-573f-bb7c-47cac02ea60f","slug":"boric-acid","display_name":"Boric acid / orthoboric acid / B(OH)3","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4ff95f93-b0fa-5a20-8c40-0b65e78a768d","slug":"circulating-boron-concentration","display_name":"Circulating boron concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/boron-research/6732506.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7deee2df94fd1ab9d173e7ddf97660bd8402d51bed8ac2bb8cac8810be66ca61\", \"start_char\": 0, \"end_char\": 652, \"text_sha256\": \"7deee2df94fd1ab9d173e7ddf97660bd8402d51bed8ac2bb8cac8810be66ca61\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Single-dose intravenous pharmacokinetics in eight adult men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"562–611 mg boric acid over 20 minutes; plasma followed three days and urine 120 hours","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Historical intravenous experimental exposure is not an oral supplement regimen. These kinetics should not be generalized to kidney impairment or every exposure route.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Boron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The measured blood level reflected elimination over roughly a day, with variation among participants.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[boron-p6732506] Boric acid single dose pharmacokinetics after intravenous administration to man. (1984). https://pubmed.ncbi.nlm.nih.gov/6732506/ DOI: 10.1007/bf00316588","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma and urine; six participants included in compartment fitting","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c5813af2-e34f-5e98-83b5-923d5fe53b31","evidence_kind":"source_excerpt","locator":"Lines 1106-1117","start_line":1106,"end_line":1117,"excerpt":"### boron-plasma-kinetics\nThe fitted terminal boric-acid half-life was 21.0 ± 4.9 hours and total clearance 54.6 ± 8.0 mL/min/1.73 m² in the intravenous study.\nCondition category: normal\nnutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The measured blood level reflected elimination over roughly a day, with variation among participants.\norganism: Human\ntissue_or_cell_type: Plasma and urine; six participants included in compartment fitting\nexperimental_model: Single-dose intravenous pharmacokinetics in eight adult men\nlimitations: Historical intravenous experimental exposure is not an oral supplement regimen. These kinetics should not be generalized to kidney impairment or every exposure route.\nexposure: 562–611 mg boric acid over 20 minutes; plasma followed three days and urine 120 hours\nevidence_span: {\"source_cache\": \"artifacts/boron-research/6732506.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7deee2df94fd1ab9d173e7ddf97660bd8402d51bed8ac2bb8cac8810be66ca61\", \"start_char\": 0, \"end_char\": 652, \"text_sha256\": \"7deee2df94fd1ab9d173e7ddf97660bd8402d51bed8ac2bb8cac8810be66ca61\"}\n[boron-p6732506] Boric acid single dose pharmacokinetics after intravenous administration to man. (1984). https://pubmed.ncbi.nlm.nih.gov/6732506/ DOI: 10.1007/bf00316588","model_system":"Single-dose intravenous pharmacokinetics in eight adult men","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [boron-p6732506] Boric acid single dose pharmacokinetics after intravenous administration to man. (1984). https://pubmed.ncbi.nlm.nih.gov/6732506/ DOI: 10.1007/bf00316588","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2d96c547-aeec-5d8b-9d31-1288da209f89","stable_key":"import-7edf94bb-95c8-5234-9161-9eb338bb9b36","title":"Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"0a32c1c5c70cfb4a378f6ace35cf5b75d90ed3065ada91b9f9f64015d603c8e3","revision_id":"38f316f2-4344-542e-a638-0ac5402f678d","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}