{"id":"b742c88e-cfea-5e40-a638-3cc96bab63a8","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-feeding-boron-homeostasis","predicate":"modulates","statement":"A ninefold difference in dietary boron produced only a 1.5-fold difference in plasma boron; fecal plus urinary excretion accounted for almost all intake without progressive accumulation.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"1a5dd9ed-cbb6-579f-ba69-7ddda167adf0","mechanism_event_label":"Blood boron did not rise in proportion to intake because the body eliminated much of the exposure.","subject":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"object":{"id":"4ff95f93-b0fa-5a20-8c40-0b65e78a768d","slug":"circulating-boron-concentration","display_name":"Circulating boron concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1a5dd9ed-cbb6-579f-ba69-7ddda167adf0","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-feeding-boron-homeostasis-event","event_type":"observed_intervention","label":"Blood boron did not rise in proportion to intake because the body eliminated much of the exposure.","description":"A ninefold difference in dietary boron produced only a 1.5-fold difference in plasma boron; fecal plus urinary excretion accounted for almost all intake without progressive accumulation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5ba7ded0-4d95-5ca2-ab42-da72fefef649","slug":"urinary-boron-excretion","display_name":"Urinary boron excretion","entity_type_key":"cellular_process"},"role":"measured_output","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"4ff95f93-b0fa-5a20-8c40-0b65e78a768d","slug":"circulating-boron-concentration","display_name":"Circulating boron concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/boron-research/9062533.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a23cd1fe09277bdd83b690746d4bbaf4742cdd74e51d5b27ee898bd87208b2be\", \"start_char\": 0, \"end_char\": 1720, \"text_sha256\": \"a23cd1fe09277bdd83b690746d4bbaf4742cdd74e51d5b27ee898bd87208b2be\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Metabolic-ward feeding; 11 postmenopausal volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"167-day study; basal 0.36 mg B and 109 mg Mg/8400 kJ; 3 mg/day B supplement in last two 24-day periods; magnesium supplement 0 or 200 mg/day","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small study with multiple dietary periods and supplements. Do not assume independence from related reports from the same research program. Urine composition is not a kidney-stone clinical endpoint.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Boron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Blood boron did not rise in proportion to intake because the body eliminated much of the exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[boron-p9062533] Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations. 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Do not assume independence from related reports from the same research program. Urine composition is not a kidney-stone clinical endpoint.\nexposure: 167-day study; basal 0.36 mg B and 109 mg Mg/8400 kJ; 3 mg/day B supplement in last two 24-day periods; magnesium supplement 0 or 200 mg/day\nevidence_span: {\"source_cache\": \"artifacts/boron-research/9062533.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a23cd1fe09277bdd83b690746d4bbaf4742cdd74e51d5b27ee898bd87208b2be\", \"start_char\": 0, \"end_char\": 1720, \"text_sha256\": \"a23cd1fe09277bdd83b690746d4bbaf4742cdd74e51d5b27ee898bd87208b2be\"}\n[boron-p9062533] Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations. 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