Component

Thioredoxin reductase preparations in the 2009 analogue study; isoform/species unresolved from abstract

Thioredoxin reductase preparations in the 2009 analogue study; isoform/species unresolved from abstract. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. The synthetic 5-fluoro-2-hydroxy analogue inhibited recombinant TrxR with IC50 7 micromolar after one hour.

    5-Fluoro-2-hydroxycinnamaldehyde, synthetic analogue → Thioredoxin reductase preparations in the 2009 analogue study; isoform/species unresolved from abstract source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/ceylon-research/19837157.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "49ea5e5f0f771d7ac09c9072aae28a1bf3ad872bb9e9ec4ac22bc7070ac348cb", "start_char": 0, "end_char": 1607, "text_sha256": "49ea5e5f0f771d7ac09c9072aae28a1bf3ad872bb9e9ec4ac22bc7070ac348cb"}
    experimental_model
    Synthetic analogue screen, recombinant enzyme and cancer-cell assays
    exposure
    Parent cinnamaldehyde versus substituted analogues; recombinant enzyme incubation 1 hour
    limitations
    Selenocysteine was a possible target, not a demonstrated dietary selenium depletion pathway. Strong analogue potency must not be assigned to the parent or spice.
    nutrient_topic
    Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
    organism
    Recombinant TrxR species/isoform unresolved here; human HCT116 cells
    plain_language
    A separately named synthetic analogue strongly inhibited the enzyme in this assay.
    primary_references
    [ceylon-p19837157] Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention. (2010). https://pubmed.ncbi.nlm.nih.gov/19837157/ DOI: 10.1016/j.freeradbiomed.2009.10.028
    tissue_or_cell_type
    Thioredoxin reductase assays and cultured cells

    Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 714–725

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Synthetic analogue screen, recombinant enzyme and cancer-cell assays · source_derived_draft · unverified_draft

    ### ceylon-trx-analogue The synthetic 5-fluoro-2-hydroxy analogue inhibited recombinant TrxR with IC50 7 micromolar after one hour. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: A separately named synthetic analogue strongly inhibited the enzyme in this assay. organism: Recombinant TrxR species/isoform unresolved here; human HCT116 cells tissue_or_cell_type: Thioredoxin reductase assays and cultured cells experimental_model: Synthetic analogue screen, recombinant enzyme and cancer-cell assays limitations: Selenocysteine was a possible target, not a demonstrated dietary selenium depletion pathway. Strong analogue potency must not be assigned to the parent or spice. exposure: Parent cinnamaldehyde versus substituted analogues; recombinant enzyme incubation 1 hour evidence_span: {"source_cache": "artifacts/ceylon-research/19837157.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "49ea5e5f0f771d7ac09c9072aae28a1bf3ad872bb9e9ec4ac22bc7070ac348cb", "start_char": 0, "end_char": 1607, "text_sha256": "49ea5e5f0f771d7ac09c9072aae28a1bf3ad872bb9e9ec4ac22bc7070ac348cb"} [ceylon-p19837157] Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention. (2010). https://pubmed.ncbi.nlm.nih.gov/19837157/ DOI: 10.1016/j.freeradbiomed.2009.10.028
    Complete structured claim and evidence

  2. Parent cinnamaldehyde was a weak TrxR inhibitor compared with the more potent hydroxy- and benzoyloxy-substituted analogues.

    trans-Cinnamaldehyde / cinnamal → Thioredoxin reductase preparations in the 2009 analogue study; isoform/species unresolved from abstract source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/ceylon-research/19837157.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "49ea5e5f0f771d7ac09c9072aae28a1bf3ad872bb9e9ec4ac22bc7070ac348cb", "start_char": 0, "end_char": 1607, "text_sha256": "49ea5e5f0f771d7ac09c9072aae28a1bf3ad872bb9e9ec4ac22bc7070ac348cb"}
    experimental_model
    Synthetic analogue screen, recombinant enzyme and cancer-cell assays
    exposure
    Parent cinnamaldehyde versus substituted analogues; recombinant enzyme incubation 1 hour
    limitations
    Selenocysteine was a possible target, not a demonstrated dietary selenium depletion pathway. Strong analogue potency must not be assigned to the parent or spice.
    nutrient_topic
    Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
    organism
    Recombinant TrxR species/isoform unresolved here; human HCT116 cells
    plain_language
    The stronger laboratory results belonged to modified chemicals, not ordinary cinnamon.
    primary_references
    [ceylon-p19837157] Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention. (2010). https://pubmed.ncbi.nlm.nih.gov/19837157/ DOI: 10.1016/j.freeradbiomed.2009.10.028
    tissue_or_cell_type
    Thioredoxin reductase assays and cultured cells

    Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 701–712

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Synthetic analogue screen, recombinant enzyme and cancer-cell assays · source_derived_draft · unverified_draft

    ### ceylon-trx-parent Parent cinnamaldehyde was a weak TrxR inhibitor compared with the more potent hydroxy- and benzoyloxy-substituted analogues. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: The stronger laboratory results belonged to modified chemicals, not ordinary cinnamon. organism: Recombinant TrxR species/isoform unresolved here; human HCT116 cells tissue_or_cell_type: Thioredoxin reductase assays and cultured cells experimental_model: Synthetic analogue screen, recombinant enzyme and cancer-cell assays limitations: Selenocysteine was a possible target, not a demonstrated dietary selenium depletion pathway. Strong analogue potency must not be assigned to the parent or spice. exposure: Parent cinnamaldehyde versus substituted analogues; recombinant enzyme incubation 1 hour evidence_span: {"source_cache": "artifacts/ceylon-research/19837157.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "49ea5e5f0f771d7ac09c9072aae28a1bf3ad872bb9e9ec4ac22bc7070ac348cb", "start_char": 0, "end_char": 1607, "text_sha256": "49ea5e5f0f771d7ac09c9072aae28a1bf3ad872bb9e9ec4ac22bc7070ac348cb"} [ceylon-p19837157] Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention. (2010). https://pubmed.ncbi.nlm.nih.gov/19837157/ DOI: 10.1016/j.freeradbiomed.2009.10.028
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards