Component
5-Fluoro-2-hydroxycinnamaldehyde, synthetic analogue
5-Fluoro-2-hydroxycinnamaldehyde, synthetic analogue. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The synthetic 5-fluoro-2-hydroxy analogue inhibited recombinant TrxR with IC50 7 micromolar after one hour.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/ceylon-research/19837157.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "49ea5e5f0f771d7ac09c9072aae28a1bf3ad872bb9e9ec4ac22bc7070ac348cb", "start_char": 0, "end_char": 1607, "text_sha256": "49ea5e5f0f771d7ac09c9072aae28a1bf3ad872bb9e9ec4ac22bc7070ac348cb"}
- experimental_model
- Synthetic analogue screen, recombinant enzyme and cancer-cell assays
- exposure
- Parent cinnamaldehyde versus substituted analogues; recombinant enzyme incubation 1 hour
- limitations
- Selenocysteine was a possible target, not a demonstrated dietary selenium depletion pathway. Strong analogue potency must not be assigned to the parent or spice.
- nutrient_topic
- Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
- organism
- Recombinant TrxR species/isoform unresolved here; human HCT116 cells
- plain_language
- A separately named synthetic analogue strongly inhibited the enzyme in this assay.
- primary_references
- [ceylon-p19837157] Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention. (2010). https://pubmed.ncbi.nlm.nih.gov/19837157/ DOI: 10.1016/j.freeradbiomed.2009.10.028
- tissue_or_cell_type
- Thioredoxin reductase assays and cultured cells
Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 714–725
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Synthetic analogue screen, recombinant enzyme and cancer-cell assays · source_derived_draft · unverified_draft
### ceylon-trx-analogue The synthetic 5-fluoro-2-hydroxy analogue inhibited recombinant TrxR with IC50 7 micromolar after one hour. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: A separately named synthetic analogue strongly inhibited the enzyme in this assay. organism: Recombinant TrxR species/isoform unresolved here; human HCT116 cells tissue_or_cell_type: Thioredoxin reductase assays and cultured cells experimental_model: Synthetic analogue screen, recombinant enzyme and cancer-cell assays limitations: Selenocysteine was a possible target, not a demonstrated dietary selenium depletion pathway. Strong analogue potency must not be assigned to the parent or spice. exposure: Parent cinnamaldehyde versus substituted analogues; recombinant enzyme incubation 1 hour evidence_span: {"source_cache": "artifacts/ceylon-research/19837157.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "49ea5e5f0f771d7ac09c9072aae28a1bf3ad872bb9e9ec4ac22bc7070ac348cb", "start_char": 0, "end_char": 1607, "text_sha256": "49ea5e5f0f771d7ac09c9072aae28a1bf3ad872bb9e9ec4ac22bc7070ac348cb"} [ceylon-p19837157] Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention. (2010). https://pubmed.ncbi.nlm.nih.gov/19837157/ DOI: 10.1016/j.freeradbiomed.2009.10.028
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.