{"id":"4bfc6e75-b6fa-5060-9429-deddc25a0d99","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-trx-parent","predicate":"weakly_inhibits","statement":"Parent cinnamaldehyde was a weak TrxR inhibitor compared with the more potent hydroxy- and benzoyloxy-substituted analogues.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8e75e2cf-d384-590b-922d-cd477c520b0e","mechanism_event_label":"The stronger laboratory results belonged to modified chemicals, not ordinary cinnamon.","subject":{"id":"2dc093c6-9373-5b24-a17b-a6b21b5a0432","slug":"trans-cinnamaldehyde","display_name":"trans-Cinnamaldehyde / cinnamal","entity_type_key":"small_molecule"},"object":{"id":"7ae0421e-ee45-54d1-af79-fd05621339ba","slug":"cinnamaldehyde-trxr-preparation","display_name":"Thioredoxin reductase preparations in the 2009 analogue study; isoform/species unresolved from abstract","entity_type_key":"protein_family"},"evidence_count":1,"mechanism_event":{"id":"8e75e2cf-d384-590b-922d-cd477c520b0e","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-trx-parent-event","event_type":"biochemical_relationship","label":"The stronger laboratory results belonged to modified chemicals, not ordinary cinnamon.","description":"Parent cinnamaldehyde was a weak TrxR inhibitor compared with the more potent hydroxy- and benzoyloxy-substituted analogues.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2dc093c6-9373-5b24-a17b-a6b21b5a0432","slug":"trans-cinnamaldehyde","display_name":"trans-Cinnamaldehyde / cinnamal","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7ae0421e-ee45-54d1-af79-fd05621339ba","slug":"cinnamaldehyde-trxr-preparation","display_name":"Thioredoxin reductase preparations in the 2009 analogue study; isoform/species unresolved from abstract","entity_type_key":"protein_family"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/ceylon-research/19837157.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"49ea5e5f0f771d7ac09c9072aae28a1bf3ad872bb9e9ec4ac22bc7070ac348cb\", \"start_char\": 0, \"end_char\": 1607, \"text_sha256\": \"49ea5e5f0f771d7ac09c9072aae28a1bf3ad872bb9e9ec4ac22bc7070ac348cb\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Synthetic analogue screen, recombinant enzyme and cancer-cell assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Parent cinnamaldehyde versus substituted analogues; recombinant enzyme incubation 1 hour","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Selenocysteine was a possible target, not a demonstrated dietary selenium depletion pathway. Strong analogue potency must not be assigned to the parent or spice.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ceylon","display_name":"Ceylon cinnamon / Cinnamomum verum bark preparations","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Recombinant TrxR species/isoform unresolved here; human HCT116 cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The stronger laboratory results belonged to modified chemicals, not ordinary cinnamon.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ceylon-p19837157] Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention. (2010). https://pubmed.ncbi.nlm.nih.gov/19837157/ DOI: 10.1016/j.freeradbiomed.2009.10.028","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Thioredoxin reductase assays and cultured cells","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"923fa016-134c-546c-bcbd-9b166ef21985","evidence_kind":"source_excerpt","locator":"Lines 701-712","start_line":701,"end_line":712,"excerpt":"### ceylon-trx-parent\nParent cinnamaldehyde was a weak TrxR inhibitor compared with the more potent hydroxy- and benzoyloxy-substituted analogues.\nCondition category: normal\nnutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The stronger laboratory results belonged to modified chemicals, not ordinary cinnamon.\norganism: Recombinant TrxR species/isoform unresolved here; human HCT116 cells\ntissue_or_cell_type: Thioredoxin reductase assays and cultured cells\nexperimental_model: Synthetic analogue screen, recombinant enzyme and cancer-cell assays\nlimitations: Selenocysteine was a possible target, not a demonstrated dietary selenium depletion pathway. Strong analogue potency must not be assigned to the parent or spice.\nexposure: Parent cinnamaldehyde versus substituted analogues; recombinant enzyme incubation 1 hour\nevidence_span: {\"source_cache\": \"artifacts/ceylon-research/19837157.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"49ea5e5f0f771d7ac09c9072aae28a1bf3ad872bb9e9ec4ac22bc7070ac348cb\", \"start_char\": 0, \"end_char\": 1607, \"text_sha256\": \"49ea5e5f0f771d7ac09c9072aae28a1bf3ad872bb9e9ec4ac22bc7070ac348cb\"}\n[ceylon-p19837157] Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention. 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