Component

Trinuclear oxo chromium(III) propionate complex / Cr3

Trinuclear oxo chromium(III) propionate complex / Cr3. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. High chromium-propionate supplementation did not deepen the measured adverse iron-status and hematologic changes from iron restriction.

    Trinuclear oxo chromium(III) propionate complex / Cr3 → Iron-status and hematologic measurements source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/chromium-research/29173471.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9de0b60d39b67304da3d1042ebc5f1ed5622a5675e6a0cda4c531bf64249ef2e", "start_char": 0, "end_char": 1448, "text_sha256": "9de0b60d39b67304da3d1042ebc5f1ed5622a5675e6a0cda4c531bf64249ef2e"}
    experimental_model
    Six-week factorial chromium/iron feeding study
    exposure
    Iron at 10% versus 100% of the study reference level; chromium propionate at 1, 50 or 500 mg Cr/kg diet
    limitations
    Very high chromium doses in an animal experiment. Changes do not establish a recommended human ratio, a chromium rescue for anemia or a universal competition rule.
    nutrient_topic
    Chromium research collection; topical membership is not evidence of a direct dietary effect. · Chromium
    organism
    Female Wistar rats
    plain_language
    This animal experiment did not show the predicted worsening of iron status.
    primary_references
    [chromium-p29173471] The combined effect of supplementary Cr(III) propionate complex and iron deficiency on the chromium and iron status in female rats. (2018). https://pubmed.ncbi.nlm.nih.gov/29173471/ DOI: 10.1016/j.jtemb.2017.10.010
    tissue_or_cell_type
    Tissue metals and hematologic indices
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17) · lines 497–508

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Six-week factorial chromium/iron feeding study · source_derived_draft · unverified_draft

    ### chromium-iron-deficiency-not-worsened High chromium-propionate supplementation did not deepen the measured adverse iron-status and hematologic changes from iron restriction. Condition category: nutrient_deficiency nutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect. plain_language: This animal experiment did not show the predicted worsening of iron status. organism: Female Wistar rats tissue_or_cell_type: Tissue metals and hematologic indices experimental_model: Six-week factorial chromium/iron feeding study limitations: Very high chromium doses in an animal experiment. Changes do not establish a recommended human ratio, a chromium rescue for anemia or a universal competition rule. exposure: Iron at 10% versus 100% of the study reference level; chromium propionate at 1, 50 or 500 mg Cr/kg diet evidence_span: {"source_cache": "artifacts/chromium-research/29173471.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9de0b60d39b67304da3d1042ebc5f1ed5622a5675e6a0cda4c531bf64249ef2e", "start_char": 0, "end_char": 1448, "text_sha256": "9de0b60d39b67304da3d1042ebc5f1ed5622a5675e6a0cda4c531bf64249ef2e"} [chromium-p29173471] The combined effect of supplementary Cr(III) propionate complex and iron deficiency on the chromium and iron status in female rats. (2018). https://pubmed.ncbi.nlm.nih.gov/29173471/ DOI: 10.1016/j.jtemb.2017.10.010
    Complete structured claim and evidence

  2. Chromium supplementation reduced kidney iron with adequate dietary iron, but increasing chromium raised kidney iron when the background diet was iron-excessive.

    Trinuclear oxo chromium(III) propionate complex / Cr3 → Renal iron concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/chromium-research/29164513.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4d99145cb86f4110fd0087f9162fa057d87b445b9bc6a60c6467bb310f5e300b", "start_char": 0, "end_char": 2450, "text_sha256": "4d99145cb86f4110fd0087f9162fa057d87b445b9bc6a60c6467bb310f5e300b"}
    experimental_model
    Factorial six-group iron-excess/chromium feeding experiment
    exposure
    Iron 45 versus 180 mg/kg diet; chromium propionate 1, 50 or 500 mg Cr/kg diet; six animals/group
    limitations
    High-dose animal study. The direction changed with background iron; do not extrapolate a universal nutrient antagonism or human dose ratio.
    nutrient_topic
    Chromium research collection; topical membership is not evidence of a direct dietary effect. · Chromium
    organism
    Female Wistar rats
    plain_language
    The same supplement did not have one fixed effect on kidney iron.
    primary_references
    [chromium-p29164513] The Combined Effects of Iron Excess in the Diet and Chromium(III) Supplementation on the Iron and Chromium Status in Female Rats. (2018). https://pubmed.ncbi.nlm.nih.gov/29164513/ DOI: 10.1007/s12011-017-1203-z
    tissue_or_cell_type
    Serum, liver and kidney metals

    Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17) · lines 523–534

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Factorial six-group iron-excess/chromium feeding experiment · source_derived_draft · unverified_draft

    ### chromium-renal-iron-context Chromium supplementation reduced kidney iron with adequate dietary iron, but increasing chromium raised kidney iron when the background diet was iron-excessive. Condition category: normal nutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect. plain_language: The same supplement did not have one fixed effect on kidney iron. organism: Female Wistar rats tissue_or_cell_type: Serum, liver and kidney metals experimental_model: Factorial six-group iron-excess/chromium feeding experiment limitations: High-dose animal study. The direction changed with background iron; do not extrapolate a universal nutrient antagonism or human dose ratio. exposure: Iron 45 versus 180 mg/kg diet; chromium propionate 1, 50 or 500 mg Cr/kg diet; six animals/group evidence_span: {"source_cache": "artifacts/chromium-research/29164513.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4d99145cb86f4110fd0087f9162fa057d87b445b9bc6a60c6467bb310f5e300b", "start_char": 0, "end_char": 2450, "text_sha256": "4d99145cb86f4110fd0087f9162fa057d87b445b9bc6a60c6467bb310f5e300b"} [chromium-p29164513] The Combined Effects of Iron Excess in the Diet and Chromium(III) Supplementation on the Iron and Chromium Status in Female Rats. (2018). https://pubmed.ncbi.nlm.nih.gov/29164513/ DOI: 10.1007/s12011-017-1203-z
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Chromium supplementation raised tissue chromium less strongly in iron-deficient rats than in rats with adequate iron.

    Iron → Delivery of chromium to tissues source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/chromium-research/29173471.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9de0b60d39b67304da3d1042ebc5f1ed5622a5675e6a0cda4c531bf64249ef2e", "start_char": 0, "end_char": 1448, "text_sha256": "9de0b60d39b67304da3d1042ebc5f1ed5622a5675e6a0cda4c531bf64249ef2e"}
    experimental_model
    Six-week factorial chromium/iron feeding study
    exposure
    Iron at 10% versus 100% of the study reference level; chromium propionate at 1, 50 or 500 mg Cr/kg diet
    limitations
    Very high chromium doses in an animal experiment. Changes do not establish a recommended human ratio, a chromium rescue for anemia or a universal competition rule.
    nutrient_topic
    Chromium research collection; topical membership is not evidence of a direct dietary effect. · Chromium
    organism
    Female Wistar rats
    plain_language
    Low iron did not simply free more carrier space and increase chromium accumulation.
    primary_references
    [chromium-p29173471] The combined effect of supplementary Cr(III) propionate complex and iron deficiency on the chromium and iron status in female rats. (2018). https://pubmed.ncbi.nlm.nih.gov/29173471/ DOI: 10.1016/j.jtemb.2017.10.010
    tissue_or_cell_type
    Tissue metals and hematologic indices
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17) · lines 484–495

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Six-week factorial chromium/iron feeding study · source_derived_draft · unverified_draft

    ### chromium-iron-deficiency-chromium Chromium supplementation raised tissue chromium less strongly in iron-deficient rats than in rats with adequate iron. Condition category: nutrient_deficiency nutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Low iron did not simply free more carrier space and increase chromium accumulation. organism: Female Wistar rats tissue_or_cell_type: Tissue metals and hematologic indices experimental_model: Six-week factorial chromium/iron feeding study limitations: Very high chromium doses in an animal experiment. Changes do not establish a recommended human ratio, a chromium rescue for anemia or a universal competition rule. exposure: Iron at 10% versus 100% of the study reference level; chromium propionate at 1, 50 or 500 mg Cr/kg diet evidence_span: {"source_cache": "artifacts/chromium-research/29173471.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9de0b60d39b67304da3d1042ebc5f1ed5622a5675e6a0cda4c531bf64249ef2e", "start_char": 0, "end_char": 1448, "text_sha256": "9de0b60d39b67304da3d1042ebc5f1ed5622a5675e6a0cda4c531bf64249ef2e"} [chromium-p29173471] The combined effect of supplementary Cr(III) propionate complex and iron deficiency on the chromium and iron status in female rats. (2018). https://pubmed.ncbi.nlm.nih.gov/29173471/ DOI: 10.1016/j.jtemb.2017.10.010
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards