{"id":"312a721b-899e-57e2-b10c-a3f0bde78611","stable_key":"4d8e4781-3878-5818-8d0a-7dbd6e024555:chromium-renal-iron-context","predicate":"modulates","statement":"Chromium supplementation reduced kidney iron with adequate dietary iron, but increasing chromium raised kidney iron when the background diet was iron-excessive.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d3191651-1141-5507-869c-15d2d72910bb","mechanism_event_label":"The same supplement did not have one fixed effect on kidney iron.","subject":{"id":"b8d4f4d8-aa58-53f0-aedd-5f712c4a4c12","slug":"chromium-iii-propionate-complex","display_name":"Trinuclear oxo chromium(III) propionate complex / Cr3","entity_type_key":"chemical_species"},"object":{"id":"c14bd807-eb7e-54b8-8879-eb848ab1d857","slug":"renal-iron-concentration","display_name":"Renal iron concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d3191651-1141-5507-869c-15d2d72910bb","stable_key":"4d8e4781-3878-5818-8d0a-7dbd6e024555:chromium-renal-iron-context-event","event_type":"observed_intervention","label":"The same supplement did not have one fixed effect on kidney iron.","description":"Chromium supplementation reduced kidney iron with adequate dietary iron, but increasing chromium raised kidney iron when the background diet was iron-excessive.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"effect_modifier","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b8d4f4d8-aa58-53f0-aedd-5f712c4a4c12","slug":"chromium-iii-propionate-complex","display_name":"Trinuclear oxo chromium(III) propionate complex / Cr3","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c14bd807-eb7e-54b8-8879-eb848ab1d857","slug":"renal-iron-concentration","display_name":"Renal iron concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chromium-research/29164513.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4d99145cb86f4110fd0087f9162fa057d87b445b9bc6a60c6467bb310f5e300b\", \"start_char\": 0, \"end_char\": 2450, \"text_sha256\": \"4d99145cb86f4110fd0087f9162fa057d87b445b9bc6a60c6467bb310f5e300b\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Factorial six-group iron-excess/chromium feeding experiment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Iron 45 versus 180 mg/kg diet; chromium propionate 1, 50 or 500 mg Cr/kg diet; six animals/group","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"High-dose animal study. The direction changed with background iron; do not extrapolate a universal nutrient antagonism or human dose ratio.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chromium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chromium","display_name":"Chromium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Female Wistar rats","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The same supplement did not have one fixed effect on kidney iron.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chromium-p29164513] The Combined Effects of Iron Excess in the Diet and Chromium(III) Supplementation on the Iron and Chromium Status in Female Rats. (2018). https://pubmed.ncbi.nlm.nih.gov/29164513/ DOI: 10.1007/s12011-017-1203-z","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Serum, liver and kidney metals","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d0b70089-3ec4-54d5-88b2-d94b00cf21c9","evidence_kind":"source_excerpt","locator":"Lines 523-534","start_line":523,"end_line":534,"excerpt":"### chromium-renal-iron-context\nChromium supplementation reduced kidney iron with adequate dietary iron, but increasing chromium raised kidney iron when the background diet was iron-excessive.\nCondition category: normal\nnutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The same supplement did not have one fixed effect on kidney iron.\norganism: Female Wistar rats\ntissue_or_cell_type: Serum, liver and kidney metals\nexperimental_model: Factorial six-group iron-excess/chromium feeding experiment\nlimitations: High-dose animal study. The direction changed with background iron; do not extrapolate a universal nutrient antagonism or human dose ratio.\nexposure: Iron 45 versus 180 mg/kg diet; chromium propionate 1, 50 or 500 mg Cr/kg diet; six animals/group\nevidence_span: {\"source_cache\": \"artifacts/chromium-research/29164513.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4d99145cb86f4110fd0087f9162fa057d87b445b9bc6a60c6467bb310f5e300b\", \"start_char\": 0, \"end_char\": 2450, \"text_sha256\": \"4d99145cb86f4110fd0087f9162fa057d87b445b9bc6a60c6467bb310f5e300b\"}\n[chromium-p29164513] The Combined Effects of Iron Excess in the Diet and Chromium(III) Supplementation on the Iron and Chromium Status in Female Rats. 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