Iron-status and hematologic measurements: molecular mechanisms & dependencies

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

Chromium picolinate did not change the measured hematologic indices, serum iron or ferritin relative to placebo during the training study.
Chromium(III) picolinate / CrPic → Iron-status and hematologic measurements source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/chromium-research/9322572.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "767fd4144862b2bbc3bf416541442924fc69da030435898b1e6843dba8e35dc8", "start_char": 0, "end_char": 1869, "text_sha256": "767fd4144862b2bbc3bf416541442924fc69da030435898b1e6843dba8e35dc8"}
experimental_model
Randomized double-blind supplementation with resistance training; 18 men
exposure
924 µg chromium/day as picolinate versus placebo for 12 weeks; nine men/group
limitations
Small selected population and short follow-up. A negative result does not exclude every interaction in iron-deficient people or other exposures.
nutrient_topic
Chromium research collection; topical membership is not evidence of a direct dietary effect. · Chromium
organism
Human men aged 56–69
plain_language
The proposed iron-depleting effect was not observed in these older men.
primary_references
[chromium-p9322572] Chromium picolinate supplementation and resistive training by older men: effects on iron-status and hematologic indexes. (1997). https://pubmed.ncbi.nlm.nih.gov/9322572/ DOI: 10.1093/ajcn/66.4.944
tissue_or_cell_type
Iron-status and hematologic indices
Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17) · lines 536–547
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind supplementation with resistance training; 18 men · source_derived_draft · unverified_draft
### chromium-human-iron-status-null Chromium picolinate did not change the measured hematologic indices, serum iron or ferritin relative to placebo during the training study. Condition category: normal nutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect. plain_language: The proposed iron-depleting effect was not observed in these older men. organism: Human men aged 56–69 tissue_or_cell_type: Iron-status and hematologic indices experimental_model: Randomized double-blind supplementation with resistance training; 18 men limitations: Small selected population and short follow-up. A negative result does not exclude every interaction in iron-deficient people or other exposures. exposure: 924 µg chromium/day as picolinate versus placebo for 12 weeks; nine men/group evidence_span: {"source_cache": "artifacts/chromium-research/9322572.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "767fd4144862b2bbc3bf416541442924fc69da030435898b1e6843dba8e35dc8", "start_char": 0, "end_char": 1869, "text_sha256": "767fd4144862b2bbc3bf416541442924fc69da030435898b1e6843dba8e35dc8"} [chromium-p9322572] Chromium picolinate supplementation and resistive training by older men: effects on iron-status and hematologic indexes. (1997). https://pubmed.ncbi.nlm.nih.gov/9322572/ DOI: 10.1093/ajcn/66.4.944
Complete structured claim and evidence
High chromium-propionate supplementation did not deepen the measured adverse iron-status and hematologic changes from iron restriction.
Trinuclear oxo chromium(III) propionate complex / Cr3 → Iron-status and hematologic measurements source_derived_draftungraded
Experimental context and source evidence
availability_state
nutrient_deficiency Imported condition classification; unverified.
evidence_span
{"source_cache": "artifacts/chromium-research/29173471.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9de0b60d39b67304da3d1042ebc5f1ed5622a5675e6a0cda4c531bf64249ef2e", "start_char": 0, "end_char": 1448, "text_sha256": "9de0b60d39b67304da3d1042ebc5f1ed5622a5675e6a0cda4c531bf64249ef2e"}
experimental_model
Six-week factorial chromium/iron feeding study
exposure
Iron at 10% versus 100% of the study reference level; chromium propionate at 1, 50 or 500 mg Cr/kg diet
limitations
Very high chromium doses in an animal experiment. Changes do not establish a recommended human ratio, a chromium rescue for anemia or a universal competition rule.
nutrient_topic
Chromium research collection; topical membership is not evidence of a direct dietary effect. · Chromium
organism
Female Wistar rats
plain_language
This animal experiment did not show the predicted worsening of iron status.
primary_references
[chromium-p29173471] The combined effect of supplementary Cr(III) propionate complex and iron deficiency on the chromium and iron status in female rats. (2018). https://pubmed.ncbi.nlm.nih.gov/29173471/ DOI: 10.1016/j.jtemb.2017.10.010
tissue_or_cell_type
Tissue metals and hematologic indices
trigger_kind
nutrient_deficiency Imported condition classification; unverified.
Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17) · lines 497–508
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Six-week factorial chromium/iron feeding study · source_derived_draft · unverified_draft
### chromium-iron-deficiency-not-worsened High chromium-propionate supplementation did not deepen the measured adverse iron-status and hematologic changes from iron restriction. Condition category: nutrient_deficiency nutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect. plain_language: This animal experiment did not show the predicted worsening of iron status. organism: Female Wistar rats tissue_or_cell_type: Tissue metals and hematologic indices experimental_model: Six-week factorial chromium/iron feeding study limitations: Very high chromium doses in an animal experiment. Changes do not establish a recommended human ratio, a chromium rescue for anemia or a universal competition rule. exposure: Iron at 10% versus 100% of the study reference level; chromium propionate at 1, 50 or 500 mg Cr/kg diet evidence_span: {"source_cache": "artifacts/chromium-research/29173471.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9de0b60d39b67304da3d1042ebc5f1ed5622a5675e6a0cda4c531bf64249ef2e", "start_char": 0, "end_char": 1448, "text_sha256": "9de0b60d39b67304da3d1042ebc5f1ed5622a5675e6a0cda4c531bf64249ef2e"} [chromium-p29173471] The combined effect of supplementary Cr(III) propionate complex and iron deficiency on the chromium and iron status in female rats. (2018). https://pubmed.ncbi.nlm.nih.gov/29173471/ DOI: 10.1016/j.jtemb.2017.10.010
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

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Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

Iron-status and hematologic measurements