{"id":"1448673a-49f5-5262-b8d1-61aa17372dd6","stable_key":"4d8e4781-3878-5818-8d0a-7dbd6e024555:chromium-human-iron-status-null","predicate":"did_not_change","statement":"Chromium picolinate did not change the measured hematologic indices, serum iron or ferritin relative to placebo during the training study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"49a1c5e5-4fc2-580e-ae00-435f688c144a","mechanism_event_label":"The proposed iron-depleting effect was not observed in these older men.","subject":{"id":"89d5d39c-2663-5e0c-8eae-562a5b25a47d","slug":"chromium-iii-picolinate","display_name":"Chromium(III) picolinate / CrPic","entity_type_key":"chemical_species"},"object":{"id":"b5ece3fe-dc43-5756-9322-5d23366a5234","slug":"iron-status-indices","display_name":"Iron-status and hematologic measurements","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"49a1c5e5-4fc2-580e-ae00-435f688c144a","stable_key":"4d8e4781-3878-5818-8d0a-7dbd6e024555:chromium-human-iron-status-null-event","event_type":"observed_intervention","label":"The proposed iron-depleting effect was not observed in these older men.","description":"Chromium picolinate did not change the measured hematologic indices, serum iron or ferritin relative to placebo during the training study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"nutrient_context","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9b302959-20f9-5764-9635-793e8435e278","slug":"serum-ferritin-concentration","display_name":"Serum ferritin concentration","entity_type_key":"cellular_process"},"role":"measured_endpoint","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"89d5d39c-2663-5e0c-8eae-562a5b25a47d","slug":"chromium-iii-picolinate","display_name":"Chromium(III) picolinate / CrPic","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"b5ece3fe-dc43-5756-9322-5d23366a5234","slug":"iron-status-indices","display_name":"Iron-status and hematologic measurements","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chromium-research/9322572.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"767fd4144862b2bbc3bf416541442924fc69da030435898b1e6843dba8e35dc8\", \"start_char\": 0, \"end_char\": 1869, \"text_sha256\": \"767fd4144862b2bbc3bf416541442924fc69da030435898b1e6843dba8e35dc8\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind supplementation with resistance training; 18 men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"924 µg chromium/day as picolinate versus placebo for 12 weeks; nine men/group","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small selected population and short follow-up. A negative result does not exclude every interaction in iron-deficient people or other exposures.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chromium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chromium","display_name":"Chromium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human men aged 56–69","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The proposed iron-depleting effect was not observed in these older men.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chromium-p9322572] Chromium picolinate supplementation and resistive training by older men: effects on iron-status and hematologic indexes. (1997). https://pubmed.ncbi.nlm.nih.gov/9322572/ DOI: 10.1093/ajcn/66.4.944","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Iron-status and hematologic indices","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e697bdba-5516-5b43-bd06-cf9a3573b372","evidence_kind":"source_excerpt","locator":"Lines 536-547","start_line":536,"end_line":547,"excerpt":"### chromium-human-iron-status-null\nChromium picolinate did not change the measured hematologic indices, serum iron or ferritin relative to placebo during the training study.\nCondition category: normal\nnutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The proposed iron-depleting effect was not observed in these older men.\norganism: Human men aged 56–69\ntissue_or_cell_type: Iron-status and hematologic indices\nexperimental_model: Randomized double-blind supplementation with resistance training; 18 men\nlimitations: Small selected population and short follow-up. A negative result does not exclude every interaction in iron-deficient people or other exposures.\nexposure: 924 µg chromium/day as picolinate versus placebo for 12 weeks; nine men/group\nevidence_span: {\"source_cache\": \"artifacts/chromium-research/9322572.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"767fd4144862b2bbc3bf416541442924fc69da030435898b1e6843dba8e35dc8\", \"start_char\": 0, \"end_char\": 1869, \"text_sha256\": \"767fd4144862b2bbc3bf416541442924fc69da030435898b1e6843dba8e35dc8\"}\n[chromium-p9322572] Chromium picolinate supplementation and resistive training by older men: effects on iron-status and hematologic indexes. 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