Component
Renal iron concentration
Renal iron concentration. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Chromium supplementation reduced kidney iron with adequate dietary iron, but increasing chromium raised kidney iron when the background diet was iron-excessive.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chromium-research/29164513.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4d99145cb86f4110fd0087f9162fa057d87b445b9bc6a60c6467bb310f5e300b", "start_char": 0, "end_char": 2450, "text_sha256": "4d99145cb86f4110fd0087f9162fa057d87b445b9bc6a60c6467bb310f5e300b"}
- experimental_model
- Factorial six-group iron-excess/chromium feeding experiment
- exposure
- Iron 45 versus 180 mg/kg diet; chromium propionate 1, 50 or 500 mg Cr/kg diet; six animals/group
- limitations
- High-dose animal study. The direction changed with background iron; do not extrapolate a universal nutrient antagonism or human dose ratio.
- nutrient_topic
- Chromium research collection; topical membership is not evidence of a direct dietary effect. · Chromium
- organism
- Female Wistar rats
- plain_language
- The same supplement did not have one fixed effect on kidney iron.
- primary_references
- [chromium-p29164513] The Combined Effects of Iron Excess in the Diet and Chromium(III) Supplementation on the Iron and Chromium Status in Female Rats. (2018). https://pubmed.ncbi.nlm.nih.gov/29164513/ DOI: 10.1007/s12011-017-1203-z
- tissue_or_cell_type
- Serum, liver and kidney metals
Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17) · lines 523–534
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Factorial six-group iron-excess/chromium feeding experiment · source_derived_draft · unverified_draft
### chromium-renal-iron-context Chromium supplementation reduced kidney iron with adequate dietary iron, but increasing chromium raised kidney iron when the background diet was iron-excessive. Condition category: normal nutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect. plain_language: The same supplement did not have one fixed effect on kidney iron. organism: Female Wistar rats tissue_or_cell_type: Serum, liver and kidney metals experimental_model: Factorial six-group iron-excess/chromium feeding experiment limitations: High-dose animal study. The direction changed with background iron; do not extrapolate a universal nutrient antagonism or human dose ratio. exposure: Iron 45 versus 180 mg/kg diet; chromium propionate 1, 50 or 500 mg Cr/kg diet; six animals/group evidence_span: {"source_cache": "artifacts/chromium-research/29164513.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4d99145cb86f4110fd0087f9162fa057d87b445b9bc6a60c6467bb310f5e300b", "start_char": 0, "end_char": 2450, "text_sha256": "4d99145cb86f4110fd0087f9162fa057d87b445b9bc6a60c6467bb310f5e300b"} [chromium-p29164513] The Combined Effects of Iron Excess in the Diet and Chromium(III) Supplementation on the Iron and Chromium Status in Female Rats. (2018). https://pubmed.ncbi.nlm.nih.gov/29164513/ DOI: 10.1007/s12011-017-1203-z
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.