Component

Commercial C. zeylanicum bark oil in the 2017 fibroblast study

Commercial C. zeylanicum bark oil in the 2017 fibroblast study. Species, exposure and limitations are retained in each linked claim.

6 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. The bark oil reduced CCL2 production in the stimulated human dermal-fibroblast system.

    Commercial C. zeylanicum bark oil in the 2017 fibroblast study → Human CCL2 / monocyte chemoattractant protein 1 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/ceylon-research/28444928.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53", "start_char": 0, "end_char": 1601, "text_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53"}
    experimental_model
    Stimulated primary human dermal-fibroblast biomarker screen
    exposure
    Commercial C. zeylanicum bark oil in cell culture
    limitations
    Antiproliferative activity accompanies biomarker changes; reduced signal is not demonstrated safe wound healing or benefit from ingestion/topical use.
    nutrient_topic
    Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
    organism
    Human
    plain_language
    This was a change in a cultured-cell inflammation model, not a demonstrated clinical skin benefit.
    primary_references
    [ceylon-p28444928] Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model. (2017). https://pubmed.ncbi.nlm.nih.gov/28444928/ DOI: 10.1002/ptr.5822
    tissue_or_cell_type
    Dermal fibroblast inflammatory/fibrotic model

    Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 1039–1050

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Stimulated primary human dermal-fibroblast biomarker screen · source_derived_draft · unverified_draft

    ### ceylon-ccl2 The bark oil reduced CCL2 production in the stimulated human dermal-fibroblast system. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: This was a change in a cultured-cell inflammation model, not a demonstrated clinical skin benefit. organism: Human tissue_or_cell_type: Dermal fibroblast inflammatory/fibrotic model experimental_model: Stimulated primary human dermal-fibroblast biomarker screen limitations: Antiproliferative activity accompanies biomarker changes; reduced signal is not demonstrated safe wound healing or benefit from ingestion/topical use. exposure: Commercial C. zeylanicum bark oil in cell culture evidence_span: {"source_cache": "artifacts/ceylon-research/28444928.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53", "start_char": 0, "end_char": 1601, "text_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53"} [ceylon-p28444928] Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model. (2017). https://pubmed.ncbi.nlm.nih.gov/28444928/ DOI: 10.1002/ptr.5822
    Complete structured claim and evidence

  2. The bark oil reduced cell proliferation in the stimulated human dermal-fibroblast system.

    Commercial C. zeylanicum bark oil in the 2017 fibroblast study → Human dermal fibroblast proliferation source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/ceylon-research/28444928.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53", "start_char": 0, "end_char": 1601, "text_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53"}
    experimental_model
    Stimulated primary human dermal-fibroblast biomarker screen
    exposure
    Commercial C. zeylanicum bark oil in cell culture
    limitations
    Antiproliferative activity accompanies biomarker changes; reduced signal is not demonstrated safe wound healing or benefit from ingestion/topical use.
    nutrient_topic
    Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
    organism
    Human
    plain_language
    This was a change in a cultured-cell inflammation model, not a demonstrated clinical skin benefit.
    primary_references
    [ceylon-p28444928] Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model. (2017). https://pubmed.ncbi.nlm.nih.gov/28444928/ DOI: 10.1002/ptr.5822
    tissue_or_cell_type
    Dermal fibroblast inflammatory/fibrotic model

    Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 1000–1011

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Stimulated primary human dermal-fibroblast biomarker screen · source_derived_draft · unverified_draft

    ### ceylon-fibroblast-growth The bark oil reduced cell proliferation in the stimulated human dermal-fibroblast system. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: This was a change in a cultured-cell inflammation model, not a demonstrated clinical skin benefit. organism: Human tissue_or_cell_type: Dermal fibroblast inflammatory/fibrotic model experimental_model: Stimulated primary human dermal-fibroblast biomarker screen limitations: Antiproliferative activity accompanies biomarker changes; reduced signal is not demonstrated safe wound healing or benefit from ingestion/topical use. exposure: Commercial C. zeylanicum bark oil in cell culture evidence_span: {"source_cache": "artifacts/ceylon-research/28444928.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53", "start_char": 0, "end_char": 1601, "text_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53"} [ceylon-p28444928] Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model. (2017). https://pubmed.ncbi.nlm.nih.gov/28444928/ DOI: 10.1002/ptr.5822
    Complete structured claim and evidence

  3. The bark oil reduced ICAM1 production in the stimulated human dermal-fibroblast system.

    Commercial C. zeylanicum bark oil in the 2017 fibroblast study → Human intercellular adhesion molecule 1 / ICAM1 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/ceylon-research/28444928.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53", "start_char": 0, "end_char": 1601, "text_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53"}
    experimental_model
    Stimulated primary human dermal-fibroblast biomarker screen
    exposure
    Commercial C. zeylanicum bark oil in cell culture
    limitations
    Antiproliferative activity accompanies biomarker changes; reduced signal is not demonstrated safe wound healing or benefit from ingestion/topical use.
    nutrient_topic
    Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
    organism
    Human
    plain_language
    This was a change in a cultured-cell inflammation model, not a demonstrated clinical skin benefit.
    primary_references
    [ceylon-p28444928] Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model. (2017). https://pubmed.ncbi.nlm.nih.gov/28444928/ DOI: 10.1002/ptr.5822
    tissue_or_cell_type
    Dermal fibroblast inflammatory/fibrotic model

    Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 1026–1037

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Stimulated primary human dermal-fibroblast biomarker screen · source_derived_draft · unverified_draft

    ### ceylon-icam1 The bark oil reduced ICAM1 production in the stimulated human dermal-fibroblast system. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: This was a change in a cultured-cell inflammation model, not a demonstrated clinical skin benefit. organism: Human tissue_or_cell_type: Dermal fibroblast inflammatory/fibrotic model experimental_model: Stimulated primary human dermal-fibroblast biomarker screen limitations: Antiproliferative activity accompanies biomarker changes; reduced signal is not demonstrated safe wound healing or benefit from ingestion/topical use. exposure: Commercial C. zeylanicum bark oil in cell culture evidence_span: {"source_cache": "artifacts/ceylon-research/28444928.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53", "start_char": 0, "end_char": 1601, "text_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53"} [ceylon-p28444928] Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model. (2017). https://pubmed.ncbi.nlm.nih.gov/28444928/ DOI: 10.1002/ptr.5822
    Complete structured claim and evidence

  4. The bark oil reduced MMP1 production in the stimulated human dermal-fibroblast system.

    Commercial C. zeylanicum bark oil in the 2017 fibroblast study → Human matrix metalloproteinase 1 / MMP1 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/ceylon-research/28444928.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53", "start_char": 0, "end_char": 1601, "text_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53"}
    experimental_model
    Stimulated primary human dermal-fibroblast biomarker screen
    exposure
    Commercial C. zeylanicum bark oil in cell culture
    limitations
    Antiproliferative activity accompanies biomarker changes; reduced signal is not demonstrated safe wound healing or benefit from ingestion/topical use.
    nutrient_topic
    Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
    organism
    Human
    plain_language
    This was a change in a cultured-cell inflammation model, not a demonstrated clinical skin benefit.
    primary_references
    [ceylon-p28444928] Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model. (2017). https://pubmed.ncbi.nlm.nih.gov/28444928/ DOI: 10.1002/ptr.5822
    tissue_or_cell_type
    Dermal fibroblast inflammatory/fibrotic model

    Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 1052–1063

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Stimulated primary human dermal-fibroblast biomarker screen · source_derived_draft · unverified_draft

    ### ceylon-mmp1 The bark oil reduced MMP1 production in the stimulated human dermal-fibroblast system. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: This was a change in a cultured-cell inflammation model, not a demonstrated clinical skin benefit. organism: Human tissue_or_cell_type: Dermal fibroblast inflammatory/fibrotic model experimental_model: Stimulated primary human dermal-fibroblast biomarker screen limitations: Antiproliferative activity accompanies biomarker changes; reduced signal is not demonstrated safe wound healing or benefit from ingestion/topical use. exposure: Commercial C. zeylanicum bark oil in cell culture evidence_span: {"source_cache": "artifacts/ceylon-research/28444928.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53", "start_char": 0, "end_char": 1601, "text_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53"} [ceylon-p28444928] Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model. (2017). https://pubmed.ncbi.nlm.nih.gov/28444928/ DOI: 10.1002/ptr.5822
    Complete structured claim and evidence

  5. The bark oil reduced PAI-1 production in the stimulated human dermal-fibroblast system.

    Commercial C. zeylanicum bark oil in the 2017 fibroblast study → Human SERPINE1 / plasminogen activator inhibitor 1 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/ceylon-research/28444928.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53", "start_char": 0, "end_char": 1601, "text_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53"}
    experimental_model
    Stimulated primary human dermal-fibroblast biomarker screen
    exposure
    Commercial C. zeylanicum bark oil in cell culture
    limitations
    Antiproliferative activity accompanies biomarker changes; reduced signal is not demonstrated safe wound healing or benefit from ingestion/topical use.
    nutrient_topic
    Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
    organism
    Human
    plain_language
    This was a change in a cultured-cell inflammation model, not a demonstrated clinical skin benefit.
    primary_references
    [ceylon-p28444928] Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model. (2017). https://pubmed.ncbi.nlm.nih.gov/28444928/ DOI: 10.1002/ptr.5822
    tissue_or_cell_type
    Dermal fibroblast inflammatory/fibrotic model

    Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 1065–1076

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Stimulated primary human dermal-fibroblast biomarker screen · source_derived_draft · unverified_draft

    ### ceylon-pai1 The bark oil reduced PAI-1 production in the stimulated human dermal-fibroblast system. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: This was a change in a cultured-cell inflammation model, not a demonstrated clinical skin benefit. organism: Human tissue_or_cell_type: Dermal fibroblast inflammatory/fibrotic model experimental_model: Stimulated primary human dermal-fibroblast biomarker screen limitations: Antiproliferative activity accompanies biomarker changes; reduced signal is not demonstrated safe wound healing or benefit from ingestion/topical use. exposure: Commercial C. zeylanicum bark oil in cell culture evidence_span: {"source_cache": "artifacts/ceylon-research/28444928.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53", "start_char": 0, "end_char": 1601, "text_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53"} [ceylon-p28444928] Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model. (2017). https://pubmed.ncbi.nlm.nih.gov/28444928/ DOI: 10.1002/ptr.5822
    Complete structured claim and evidence

  6. The bark oil reduced VCAM1 production in the stimulated human dermal-fibroblast system.

    Commercial C. zeylanicum bark oil in the 2017 fibroblast study → Human vascular cell adhesion molecule 1 / VCAM1 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/ceylon-research/28444928.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53", "start_char": 0, "end_char": 1601, "text_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53"}
    experimental_model
    Stimulated primary human dermal-fibroblast biomarker screen
    exposure
    Commercial C. zeylanicum bark oil in cell culture
    limitations
    Antiproliferative activity accompanies biomarker changes; reduced signal is not demonstrated safe wound healing or benefit from ingestion/topical use.
    nutrient_topic
    Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
    organism
    Human
    plain_language
    This was a change in a cultured-cell inflammation model, not a demonstrated clinical skin benefit.
    primary_references
    [ceylon-p28444928] Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model. (2017). https://pubmed.ncbi.nlm.nih.gov/28444928/ DOI: 10.1002/ptr.5822
    tissue_or_cell_type
    Dermal fibroblast inflammatory/fibrotic model

    Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 1013–1024

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Stimulated primary human dermal-fibroblast biomarker screen · source_derived_draft · unverified_draft

    ### ceylon-vcam1 The bark oil reduced VCAM1 production in the stimulated human dermal-fibroblast system. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: This was a change in a cultured-cell inflammation model, not a demonstrated clinical skin benefit. organism: Human tissue_or_cell_type: Dermal fibroblast inflammatory/fibrotic model experimental_model: Stimulated primary human dermal-fibroblast biomarker screen limitations: Antiproliferative activity accompanies biomarker changes; reduced signal is not demonstrated safe wound healing or benefit from ingestion/topical use. exposure: Commercial C. zeylanicum bark oil in cell culture evidence_span: {"source_cache": "artifacts/ceylon-research/28444928.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53", "start_char": 0, "end_char": 1601, "text_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53"} [ceylon-p28444928] Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model. (2017). https://pubmed.ncbi.nlm.nih.gov/28444928/ DOI: 10.1002/ptr.5822
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards