Component
Human dermal fibroblast proliferation
Human dermal fibroblast proliferation. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The bark oil reduced cell proliferation in the stimulated human dermal-fibroblast system.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/ceylon-research/28444928.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53", "start_char": 0, "end_char": 1601, "text_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53"}
- experimental_model
- Stimulated primary human dermal-fibroblast biomarker screen
- exposure
- Commercial C. zeylanicum bark oil in cell culture
- limitations
- Antiproliferative activity accompanies biomarker changes; reduced signal is not demonstrated safe wound healing or benefit from ingestion/topical use.
- nutrient_topic
- Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
- organism
- Human
- plain_language
- This was a change in a cultured-cell inflammation model, not a demonstrated clinical skin benefit.
- primary_references
- [ceylon-p28444928] Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model. (2017). https://pubmed.ncbi.nlm.nih.gov/28444928/ DOI: 10.1002/ptr.5822
- tissue_or_cell_type
- Dermal fibroblast inflammatory/fibrotic model
Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 1000–1011
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Stimulated primary human dermal-fibroblast biomarker screen · source_derived_draft · unverified_draft
### ceylon-fibroblast-growth The bark oil reduced cell proliferation in the stimulated human dermal-fibroblast system. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: This was a change in a cultured-cell inflammation model, not a demonstrated clinical skin benefit. organism: Human tissue_or_cell_type: Dermal fibroblast inflammatory/fibrotic model experimental_model: Stimulated primary human dermal-fibroblast biomarker screen limitations: Antiproliferative activity accompanies biomarker changes; reduced signal is not demonstrated safe wound healing or benefit from ingestion/topical use. exposure: Commercial C. zeylanicum bark oil in cell culture evidence_span: {"source_cache": "artifacts/ceylon-research/28444928.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53", "start_char": 0, "end_char": 1601, "text_sha256": "8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53"} [ceylon-p28444928] Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model. (2017). https://pubmed.ncbi.nlm.nih.gov/28444928/ DOI: 10.1002/ptr.5822
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.