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(2017). https://pubmed.ncbi.nlm.nih.gov/28444928/ DOI: 10.1002/ptr.5822","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Dermal fibroblast inflammatory/fibrotic model","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0488b89b-e370-5f28-9420-df6f0f9f028b","evidence_kind":"source_excerpt","locator":"Lines 1026-1037","start_line":1026,"end_line":1037,"excerpt":"### ceylon-icam1\nThe bark oil reduced ICAM1 production in the stimulated human dermal-fibroblast system.\nCondition category: normal\nnutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This was a change in a cultured-cell inflammation model, not a demonstrated clinical skin benefit.\norganism: Human\ntissue_or_cell_type: Dermal fibroblast inflammatory/fibrotic model\nexperimental_model: Stimulated primary human dermal-fibroblast biomarker screen\nlimitations: Antiproliferative activity accompanies biomarker changes; reduced signal is not demonstrated safe wound healing or benefit from ingestion/topical use.\nexposure: Commercial C. zeylanicum bark oil in cell culture\nevidence_span: {\"source_cache\": \"artifacts/ceylon-research/28444928.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53\", \"start_char\": 0, \"end_char\": 1601, \"text_sha256\": \"8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53\"}\n[ceylon-p28444928] Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model. 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