{"id":"d93f5a93-43a5-514c-be5b-145a636972e3","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-pai1","predicate":"reduces","statement":"The bark oil reduced PAI-1 production in the stimulated human dermal-fibroblast system.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"bb27b141-9be2-55a5-8461-434e105365f7","mechanism_event_label":"This was a change in a cultured-cell inflammation model, not a demonstrated clinical skin benefit.","subject":{"id":"99738739-553f-5d2b-a2cf-6e65e9b52889","slug":"ceylon-bark-oil-fibroblasts","display_name":"Commercial C. zeylanicum bark oil in the 2017 fibroblast study","entity_type_key":"chemical_species"},"object":{"id":"b4b08646-fd4e-5294-8fab-b29e62ff988a","slug":"human-serpine1","display_name":"Human SERPINE1 / plasminogen activator inhibitor 1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"bb27b141-9be2-55a5-8461-434e105365f7","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-pai1-event","event_type":"biochemical_relationship","label":"This was a change in a cultured-cell inflammation model, not a demonstrated clinical skin benefit.","description":"The bark oil reduced PAI-1 production in the stimulated human dermal-fibroblast system.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"99738739-553f-5d2b-a2cf-6e65e9b52889","slug":"ceylon-bark-oil-fibroblasts","display_name":"Commercial C. zeylanicum bark oil in the 2017 fibroblast study","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b4b08646-fd4e-5294-8fab-b29e62ff988a","slug":"human-serpine1","display_name":"Human SERPINE1 / plasminogen activator inhibitor 1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/ceylon-research/28444928.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53\", \"start_char\": 0, \"end_char\": 1601, \"text_sha256\": \"8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Stimulated primary human dermal-fibroblast biomarker screen","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Commercial C. zeylanicum bark oil in cell culture","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Antiproliferative activity accompanies biomarker changes; reduced signal is not demonstrated safe wound healing or benefit from ingestion/topical use.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ceylon","display_name":"Ceylon cinnamon / Cinnamomum verum bark preparations","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This was a change in a cultured-cell inflammation model, not a demonstrated clinical skin benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ceylon-p28444928] Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model. (2017). https://pubmed.ncbi.nlm.nih.gov/28444928/ DOI: 10.1002/ptr.5822","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Dermal fibroblast inflammatory/fibrotic model","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d0742be9-4977-5c97-afd9-37967516ab90","evidence_kind":"source_excerpt","locator":"Lines 1065-1076","start_line":1065,"end_line":1076,"excerpt":"### ceylon-pai1\nThe bark oil reduced PAI-1 production in the stimulated human dermal-fibroblast system.\nCondition category: normal\nnutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This was a change in a cultured-cell inflammation model, not a demonstrated clinical skin benefit.\norganism: Human\ntissue_or_cell_type: Dermal fibroblast inflammatory/fibrotic model\nexperimental_model: Stimulated primary human dermal-fibroblast biomarker screen\nlimitations: Antiproliferative activity accompanies biomarker changes; reduced signal is not demonstrated safe wound healing or benefit from ingestion/topical use.\nexposure: Commercial C. zeylanicum bark oil in cell culture\nevidence_span: {\"source_cache\": \"artifacts/ceylon-research/28444928.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53\", \"start_char\": 0, \"end_char\": 1601, \"text_sha256\": \"8abd44e4f6be7090f7789d8a303e7e7ad9b0070bc22ad6c22354fdfd1fbbfb53\"}\n[ceylon-p28444928] Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model. (2017). https://pubmed.ncbi.nlm.nih.gov/28444928/ DOI: 10.1002/ptr.5822","model_system":"Stimulated primary human dermal-fibroblast biomarker screen","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ceylon-p28444928] Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model. (2017). https://pubmed.ncbi.nlm.nih.gov/28444928/ DOI: 10.1002/ptr.5822","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3aed3c5b-8016-5e37-ad6f-9019d34d19eb","stable_key":"import-3d41d18a-e13a-59a0-a081-55bfcdd43e55","title":"Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"639b1d8dcff42f2cf1f00a7dc38202289b70213e37c357c375b1f5905d6cf832","revision_id":"9675eb03-ee34-5160-b928-46b6ca9d1ecc","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}