Component
Clostridium sporogenes PorA
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Clostridium sporogenes porA disruption reduced the oxidative conversion of phenylalanine-derived carbon to phenylacetate; labeled phenylalanine tracing supported the pathway through phenylpyruvate.
Experimental context and source evidence
- evidence_access
- Primary full text
- experimental_model
- Defined bacterial cultures and stable-isotope experiments; 100 micromolar labeled phenylalanine over 24 hours.
- limitations
- Bacterial flux is strain- and environment-dependent; no human dietary conversion fraction is established.
- nutrient_topic
- L-Phenylalanine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Phenylalanine
- plain_language
- Some gut bacteria send phenylalanine into a different metabolic route.
- primary_references
- A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32142679/ · DOI 10.1016/j.cell.2020.02.016
L-Phenylalanine: transport, protein synthesis, cofactor recycling and cross-nutrient mechanisms (2026-09-19) · lines 342–348
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Defined bacterial cultures and stable-isotope experiments; 100 micromolar labeled phenylalanine over 24 hours. · source_derived_draft · unverified_draft
## l-phenylalanine-microbial-oxidation Some gut bacteria send phenylalanine into a different metabolic route. Clostridium sporogenes porA disruption reduced the oxidative conversion of phenylalanine-derived carbon to phenylacetate; labeled phenylalanine tracing supported the pathway through phenylpyruvate. Model: Defined bacterial cultures and stable-isotope experiments; 100 micromolar labeled phenylalanine over 24 hours. Limitations: Bacterial flux is strain- and environment-dependent; no human dietary conversion fraction is established. Evidence access: Primary full text A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32142679/ · DOI 10.1016/j.cell.2020.02.016
Complete structured claim and evidence
Where it participates (unsigned role)
The C. sporogenes FldH-dependent reductive aromatic-amino-acid branch competed with the PorA-associated oxidative branch; gene perturbations changed phenylacetate versus phenylpropionate output.
Experimental context and source evidence
- evidence_access
- Primary full text
- experimental_model
- C. sporogenes mutant culture and metabolite measurements.
- limitations
- A branch in one organism is not a fixed whole-microbiome fate map.
- nutrient_topic
- L-Phenylalanine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Phenylalanine
- plain_language
- Which microbial enzymes are present can change which metabolite is produced.
- primary_references
- A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32142679/ · DOI 10.1016/j.cell.2020.02.016
L-Phenylalanine: transport, protein synthesis, cofactor recycling and cross-nutrient mechanisms (2026-09-19) · lines 350–356
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · C. sporogenes mutant culture and metabolite measurements. · source_derived_draft · unverified_draft
## l-phenylalanine-microbial-branch Which microbial enzymes are present can change which metabolite is produced. The C. sporogenes FldH-dependent reductive aromatic-amino-acid branch competed with the PorA-associated oxidative branch; gene perturbations changed phenylacetate versus phenylpropionate output. Model: C. sporogenes mutant culture and metabolite measurements. Limitations: A branch in one organism is not a fixed whole-microbiome fate map. Evidence access: Primary full text A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32142679/ · DOI 10.1016/j.cell.2020.02.016
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.