Component

Clostridium sporogenes FldH

Context-specific entity; species, compartment and exposure are stated on each claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. The C. sporogenes FldH-dependent reductive aromatic-amino-acid branch competed with the PorA-associated oxidative branch; gene perturbations changed phenylacetate versus phenylpropionate output.

    Clostridium sporogenes FldH → 3-Phenylpropionic acid / phenylpropionate source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    C. sporogenes mutant culture and metabolite measurements.
    limitations
    A branch in one organism is not a fixed whole-microbiome fate map.
    nutrient_topic
    L-Phenylalanine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Phenylalanine
    plain_language
    Which microbial enzymes are present can change which metabolite is produced.
    primary_references
    A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32142679/ · DOI 10.1016/j.cell.2020.02.016

    L-Phenylalanine: transport, protein synthesis, cofactor recycling and cross-nutrient mechanisms (2026-09-19) · lines 350–356

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · C. sporogenes mutant culture and metabolite measurements. · source_derived_draft · unverified_draft

    ## l-phenylalanine-microbial-branch Which microbial enzymes are present can change which metabolite is produced. The C. sporogenes FldH-dependent reductive aromatic-amino-acid branch competed with the PorA-associated oxidative branch; gene perturbations changed phenylacetate versus phenylpropionate output. Model: C. sporogenes mutant culture and metabolite measurements. Limitations: A branch in one organism is not a fixed whole-microbiome fate map. Evidence access: Primary full text A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32142679/ · DOI 10.1016/j.cell.2020.02.016
    Complete structured claim and evidence

  2. C. sporogenes fldH disruption impaired the reductive metabolism of aromatic amino acids needed for indolepropionate production.

    Clostridium sporogenes FldH → Indole-3-propionic acid / indolepropionate source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary full text, Figure 3
    experimental_model
    Bacterial targeted-mutant metabolomics.
    limitations
    Genetic pathway necessity is not a purified-enzyme substrate-specificity measurement.
    nutrient_topic
    Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Tryptophan
    plain_language
    The microbial route needs more than one enzyme.
    primary_references
    A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites. · 2017 · https://pubmed.ncbi.nlm.nih.gov/29168502/ · DOI 10.1038/nature24661
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Tryptophan: transport, protein synthesis, neuroactive metabolites, NAD and microbial pathways (2026-09-19) · lines 498–504

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Bacterial targeted-mutant metabolomics. · source_derived_draft · unverified_draft

    ## tryptophan-fldh-loss The microbial route needs more than one enzyme. C. sporogenes fldH disruption impaired the reductive metabolism of aromatic amino acids needed for indolepropionate production. Model: Bacterial targeted-mutant metabolomics. Limitations: Genetic pathway necessity is not a purified-enzyme substrate-specificity measurement. Evidence access: Primary full text, Figure 3 A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites. · 2017 · https://pubmed.ncbi.nlm.nih.gov/29168502/ · DOI 10.1038/nature24661
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards