{"id":"f6e65bfc-9cea-536b-bc08-d7c4ac2f7478","stable_key":"56f1d914-e7da-595a-af69-c217b2b47407:l-phenylalanine-microbial-branch","predicate":"supports_competing_formation_of","statement":"The C. sporogenes FldH-dependent reductive aromatic-amino-acid branch competed with the PorA-associated oxidative branch; gene perturbations changed phenylacetate versus phenylpropionate output.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8dde2488-bb7a-55bf-bc74-9bef98c6d3b4","mechanism_event_label":"Which microbial enzymes are present can change which metabolite is produced.","subject":{"id":"6c5f6b75-d6ec-59e3-bcf7-7f2e2155e694","slug":"c-sporogenes-fldh","display_name":"Clostridium sporogenes FldH","entity_type_key":"protein"},"object":{"id":"d635d4de-2e00-50ea-83e9-69d78838d6c9","slug":"phenylpropionic-acid","display_name":"3-Phenylpropionic acid / phenylpropionate","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"8dde2488-bb7a-55bf-bc74-9bef98c6d3b4","stable_key":"56f1d914-e7da-595a-af69-c217b2b47407:l-phenylalanine-microbial-branch-event","event_type":"observed_relationship","label":"Which microbial enzymes are present can change which metabolite is produced.","description":"The C. sporogenes FldH-dependent reductive aromatic-amino-acid branch competed with the PorA-associated oxidative branch; 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gene perturbations changed phenylacetate versus phenylpropionate output.\nModel: C. sporogenes mutant culture and metabolite measurements.\nLimitations: A branch in one organism is not a fixed whole-microbiome fate map.\nEvidence access: Primary full text\nA Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32142679/ · DOI 10.1016/j.cell.2020.02.016","model_system":"C. sporogenes mutant culture and metabolite measurements.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"54de7c56-1e60-5d7b-8ef9-852c58ae92ba","stable_key":"import-56f1d914-e7da-595a-af69-c217b2b47407","title":"L-Phenylalanine: transport, protein synthesis, cofactor recycling and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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