Component

Brown adipose tissue glucose uptake

Brown adipose tissue glucose uptake. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Cold-activated brown adipose tissue activity was significantly lower in overweight or obese subjects than in lean subjects, with body-mass index and percentage body fat both negatively correlated and resting metabolic rate positively correlated.

    Brown adipose tissue glucose uptake → Body fat mass source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/cold-research/19357405.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "fc69ba9ec6aa4e295cde530497a3ef435ad5fa436888932b81565c05eb4ecf67", "start_char": 0, "end_char": 2035, "text_sha256": "fc69ba9ec6aa4e295cde530497a3ef435ad5fa436888932b81565c05eb4ecf67"}
    experimental_model
    Twenty-four lean and overweight healthy men studied by integrated FDG PET and CT
    exposure
    Thermoneutral 22 degrees C versus mild cold exposure at 16 degrees C
    limitations
    A systematic human survey establishing that the tissue is present and cold-activated. Glucose uptake on PET is an activity surrogate, not a heat measurement.
    nutrient_topic
    Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
    organism
    Human
    plain_language
    The people with more fat had less of the tissue that burns it.
    primary_references
    [cold-p19357405] Cold-activated brown adipose tissue in healthy men. (2009). https://pubmed.ncbi.nlm.nih.gov/19357405/ DOI: 10.1056/nejmoa0808718
    tissue_or_cell_type
    Supraclavicular and paravertebral brown adipose tissue

    Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 260–271

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Twenty-four lean and overweight healthy men studied by integrated FDG PET and CT · source_derived_draft · unverified_draft

    ### cold-bat-inverse-adiposity Cold-activated brown adipose tissue activity was significantly lower in overweight or obese subjects than in lean subjects, with body-mass index and percentage body fat both negatively correlated and resting metabolic rate positively correlated. Condition category: normal nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: The people with more fat had less of the tissue that burns it. organism: Human tissue_or_cell_type: Supraclavicular and paravertebral brown adipose tissue experimental_model: Twenty-four lean and overweight healthy men studied by integrated FDG PET and CT limitations: A systematic human survey establishing that the tissue is present and cold-activated. Glucose uptake on PET is an activity surrogate, not a heat measurement. exposure: Thermoneutral 22 degrees C versus mild cold exposure at 16 degrees C evidence_span: {"source_cache": "artifacts/cold-research/19357405.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "fc69ba9ec6aa4e295cde530497a3ef435ad5fa436888932b81565c05eb4ecf67", "start_char": 0, "end_char": 2035, "text_sha256": "fc69ba9ec6aa4e295cde530497a3ef435ad5fa436888932b81565c05eb4ecf67"} [cold-p19357405] Cold-activated brown adipose tissue in healthy men. (2009). https://pubmed.ncbi.nlm.nih.gov/19357405/ DOI: 10.1056/nejmoa0808718
    Complete structured claim and evidence

What acts on it

  1. Brown adipose tissue activity was observed in 23 of 24 subjects during cold exposure at 16 degrees C but not under thermoneutral conditions.

    Brown adipose tissue → Brown adipose tissue glucose uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/cold-research/19357405.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "fc69ba9ec6aa4e295cde530497a3ef435ad5fa436888932b81565c05eb4ecf67", "start_char": 0, "end_char": 2035, "text_sha256": "fc69ba9ec6aa4e295cde530497a3ef435ad5fa436888932b81565c05eb4ecf67"}
    experimental_model
    Twenty-four lean and overweight healthy men studied by integrated FDG PET and CT
    exposure
    Thermoneutral 22 degrees C versus mild cold exposure at 16 degrees C
    limitations
    A systematic human survey establishing that the tissue is present and cold-activated. Glucose uptake on PET is an activity surrogate, not a heat measurement.
    nutrient_topic
    Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
    organism
    Human
    plain_language
    Nearly every young adult has this tissue, and only cold switches it on.
    primary_references
    [cold-p19357405] Cold-activated brown adipose tissue in healthy men. (2009). https://pubmed.ncbi.nlm.nih.gov/19357405/ DOI: 10.1056/nejmoa0808718
    tissue_or_cell_type
    Supraclavicular and paravertebral brown adipose tissue

    Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 247–258

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Twenty-four lean and overweight healthy men studied by integrated FDG PET and CT · source_derived_draft · unverified_draft

    ### cold-bat-present-in-adults Brown adipose tissue activity was observed in 23 of 24 subjects during cold exposure at 16 degrees C but not under thermoneutral conditions. Condition category: normal nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: Nearly every young adult has this tissue, and only cold switches it on. organism: Human tissue_or_cell_type: Supraclavicular and paravertebral brown adipose tissue experimental_model: Twenty-four lean and overweight healthy men studied by integrated FDG PET and CT limitations: A systematic human survey establishing that the tissue is present and cold-activated. Glucose uptake on PET is an activity surrogate, not a heat measurement. exposure: Thermoneutral 22 degrees C versus mild cold exposure at 16 degrees C evidence_span: {"source_cache": "artifacts/cold-research/19357405.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "fc69ba9ec6aa4e295cde530497a3ef435ad5fa436888932b81565c05eb4ecf67", "start_char": 0, "end_char": 2035, "text_sha256": "fc69ba9ec6aa4e295cde530497a3ef435ad5fa436888932b81565c05eb4ecf67"} [cold-p19357405] Cold-activated brown adipose tissue in healthy men. (2009). https://pubmed.ncbi.nlm.nih.gov/19357405/ DOI: 10.1056/nejmoa0808718
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Basal skeletal muscle GLUT4 translocation markedly increased without effects on insulin signalling or AMPK activation, and with only a minor increase in brown adipose glucose uptake.

    Cold water immersion → Basal skeletal-muscle GLUT4 translocation source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/cold-research/26147760.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ec2d7942d906f2c11c73487b4afb7682386a7b5759541dde161dde72787503c9", "start_char": 0, "end_char": 451, "text_sha256": "ec2d7942d906f2c11c73487b4afb7682386a7b5759541dde161dde72787503c9"}
    experimental_model
    Eight subjects with type 2 diabetes acclimated to 14 to 15 degrees C for ten days
    exposure
    Ten days of cold acclimation at 14 to 15 degrees C
    limitations
    A small uncontrolled intervention in patients. The effect ran through muscle GLUT4 rather than brown fat, which is the opposite of the expected route.
    nutrient_topic
    Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
    organism
    Human
    plain_language
    The glucose door opened in muscle, not in brown fat, and not through the usual signalling.
    primary_references
    [cold-p26147760] Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus. (2015). https://pubmed.ncbi.nlm.nih.gov/26147760/ DOI: 10.1038/nm.3891
    tissue_or_cell_type
    Skeletal muscle and brown adipose tissue

    Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 871–882

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Eight subjects with type 2 diabetes acclimated to 14 to 15 degrees C for ten days · source_derived_draft · unverified_draft

    ### cold-cold-glut4-route Basal skeletal muscle GLUT4 translocation markedly increased without effects on insulin signalling or AMPK activation, and with only a minor increase in brown adipose glucose uptake. Condition category: normal nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: The glucose door opened in muscle, not in brown fat, and not through the usual signalling. organism: Human tissue_or_cell_type: Skeletal muscle and brown adipose tissue experimental_model: Eight subjects with type 2 diabetes acclimated to 14 to 15 degrees C for ten days limitations: A small uncontrolled intervention in patients. The effect ran through muscle GLUT4 rather than brown fat, which is the opposite of the expected route. exposure: Ten days of cold acclimation at 14 to 15 degrees C evidence_span: {"source_cache": "artifacts/cold-research/26147760.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ec2d7942d906f2c11c73487b4afb7682386a7b5759541dde161dde72787503c9", "start_char": 0, "end_char": 451, "text_sha256": "ec2d7942d906f2c11c73487b4afb7682386a7b5759541dde161dde72787503c9"} [cold-p26147760] Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus. (2015). https://pubmed.ncbi.nlm.nih.gov/26147760/ DOI: 10.1038/nm.3891
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards