{"id":"b0217949-71cb-599e-92dd-123a59b83dab","stable_key":"b3c3f45a-50fb-5b79-98d7-5e5228df00db:cold-bat-present-in-adults","predicate":"is_activated_by","statement":"Brown adipose tissue activity was observed in 23 of 24 subjects during cold exposure at 16 degrees C but not under thermoneutral conditions.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"a253959d-cd32-51a8-a58d-949d35355ece","mechanism_event_label":"Nearly every young adult has this tissue, and only cold switches it on.","subject":{"id":"5112507e-5510-574b-9b0a-231816fc28b3","slug":"brown-adipose-tissue","display_name":"Brown adipose tissue","entity_type_key":"cell_type"},"object":{"id":"6f8e5ae1-088e-501d-a613-20d8f9693554","slug":"bat-glucose-uptake","display_name":"Brown adipose tissue glucose uptake","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a253959d-cd32-51a8-a58d-949d35355ece","stable_key":"b3c3f45a-50fb-5b79-98d7-5e5228df00db:cold-bat-present-in-adults-event","event_type":"observed_intervention","label":"Nearly every young adult has this tissue, and only cold switches it on.","description":"Brown adipose tissue activity was observed in 23 of 24 subjects during cold exposure at 16 degrees C but not under thermoneutral conditions.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5112507e-5510-574b-9b0a-231816fc28b3","slug":"brown-adipose-tissue","display_name":"Brown adipose tissue","entity_type_key":"cell_type"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6f8e5ae1-088e-501d-a613-20d8f9693554","slug":"bat-glucose-uptake","display_name":"Brown adipose tissue glucose uptake","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/cold-research/19357405.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"fc69ba9ec6aa4e295cde530497a3ef435ad5fa436888932b81565c05eb4ecf67\", \"start_char\": 0, \"end_char\": 2035, \"text_sha256\": \"fc69ba9ec6aa4e295cde530497a3ef435ad5fa436888932b81565c05eb4ecf67\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Twenty-four lean and overweight healthy men studied by integrated FDG PET and CT","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Thermoneutral 22 degrees C versus mild cold exposure at 16 degrees C","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A systematic human survey establishing that the tissue is present and cold-activated. Glucose uptake on PET is an activity surrogate, not a heat measurement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Nearly every young adult has this tissue, and only cold switches it on.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cold-p19357405] Cold-activated brown adipose tissue in healthy men. (2009). https://pubmed.ncbi.nlm.nih.gov/19357405/ DOI: 10.1056/nejmoa0808718","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Supraclavicular and paravertebral brown adipose tissue","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3d253fda-aff9-546c-ab93-52c139b56a3b","evidence_kind":"source_excerpt","locator":"Lines 247-258","start_line":247,"end_line":258,"excerpt":"### cold-bat-present-in-adults\nBrown adipose tissue activity was observed in 23 of 24 subjects during cold exposure at 16 degrees C but not under thermoneutral conditions.\nCondition category: normal\nnutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.\nplain_language: Nearly every young adult has this tissue, and only cold switches it on.\norganism: Human\ntissue_or_cell_type: Supraclavicular and paravertebral brown adipose tissue\nexperimental_model: Twenty-four lean and overweight healthy men studied by integrated FDG PET and CT\nlimitations: A systematic human survey establishing that the tissue is present and cold-activated. Glucose uptake on PET is an activity surrogate, not a heat measurement.\nexposure: Thermoneutral 22 degrees C versus mild cold exposure at 16 degrees C\nevidence_span: {\"source_cache\": \"artifacts/cold-research/19357405.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"fc69ba9ec6aa4e295cde530497a3ef435ad5fa436888932b81565c05eb4ecf67\", \"start_char\": 0, \"end_char\": 2035, \"text_sha256\": \"fc69ba9ec6aa4e295cde530497a3ef435ad5fa436888932b81565c05eb4ecf67\"}\n[cold-p19357405] Cold-activated brown adipose tissue in healthy men. (2009). https://pubmed.ncbi.nlm.nih.gov/19357405/ DOI: 10.1056/nejmoa0808718","model_system":"Twenty-four lean and overweight healthy men studied by integrated FDG PET and CT","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [cold-p19357405] Cold-activated brown adipose tissue in healthy men. (2009). https://pubmed.ncbi.nlm.nih.gov/19357405/ DOI: 10.1056/nejmoa0808718","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"feeccadc-1392-573e-a0b5-0939ee5de6e2","stable_key":"import-b3c3f45a-50fb-5b79-98d7-5e5228df00db","title":"Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"557f074d372c49c502c34e648651aff7ebf2c8816305d2d2f08e338a7e96a5f0","revision_id":"ecc19e8d-40db-5b5d-b98e-0507f645976c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}