{"id":"c2cc14e2-098a-5afc-80cd-f40cde09333f","stable_key":"b3c3f45a-50fb-5b79-98d7-5e5228df00db:cold-bat-inverse-adiposity","predicate":"associated_with","statement":"Cold-activated brown adipose tissue activity was significantly lower in overweight or obese subjects than in lean subjects, with body-mass index and percentage body fat both negatively correlated and resting metabolic rate positively correlated.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"f2d6a37e-fcad-571a-9511-badb7a206764","mechanism_event_label":"The people with more fat had less of the tissue that burns it.","subject":{"id":"6f8e5ae1-088e-501d-a613-20d8f9693554","slug":"bat-glucose-uptake","display_name":"Brown adipose tissue glucose uptake","entity_type_key":"cellular_process"},"object":{"id":"edcc4ee6-dcac-54ec-b2e2-1aaa2adcc807","slug":"body-fat-mass","display_name":"Body fat mass","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f2d6a37e-fcad-571a-9511-badb7a206764","stable_key":"b3c3f45a-50fb-5b79-98d7-5e5228df00db:cold-bat-inverse-adiposity-event","event_type":"observed_intervention","label":"The people with more fat had less of the tissue that burns it.","description":"Cold-activated brown adipose tissue activity was significantly lower in overweight or obese subjects than in lean subjects, with body-mass index and percentage body fat both negatively correlated and resting metabolic rate positively correlated.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f852c25a-227b-571c-9f86-257dd9c90113","slug":"metabolic-rate","display_name":"Whole-body metabolic rate","entity_type_key":"cellular_process"},"role":"correlated_measure","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6f8e5ae1-088e-501d-a613-20d8f9693554","slug":"bat-glucose-uptake","display_name":"Brown adipose tissue glucose uptake","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"edcc4ee6-dcac-54ec-b2e2-1aaa2adcc807","slug":"body-fat-mass","display_name":"Body fat mass","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/cold-research/19357405.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"fc69ba9ec6aa4e295cde530497a3ef435ad5fa436888932b81565c05eb4ecf67\", \"start_char\": 0, \"end_char\": 2035, \"text_sha256\": \"fc69ba9ec6aa4e295cde530497a3ef435ad5fa436888932b81565c05eb4ecf67\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Twenty-four lean and overweight healthy men studied by integrated FDG PET and CT","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Thermoneutral 22 degrees C versus mild cold exposure at 16 degrees C","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A systematic human survey establishing that the tissue is present and cold-activated. Glucose uptake on PET is an activity surrogate, not a heat measurement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The people with more fat had less of the tissue that burns it.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cold-p19357405] Cold-activated brown adipose tissue in healthy men. 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Glucose uptake on PET is an activity surrogate, not a heat measurement.\nexposure: Thermoneutral 22 degrees C versus mild cold exposure at 16 degrees C\nevidence_span: {\"source_cache\": \"artifacts/cold-research/19357405.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"fc69ba9ec6aa4e295cde530497a3ef435ad5fa436888932b81565c05eb4ecf67\", \"start_char\": 0, \"end_char\": 2035, \"text_sha256\": \"fc69ba9ec6aa4e295cde530497a3ef435ad5fa436888932b81565c05eb4ecf67\"}\n[cold-p19357405] Cold-activated brown adipose tissue in healthy men. (2009). https://pubmed.ncbi.nlm.nih.gov/19357405/ DOI: 10.1056/nejmoa0808718","model_system":"Twenty-four lean and overweight healthy men studied by integrated FDG PET and CT","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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