Component

Arteriolar dilation

Independent biological entity. Read linked claims for experimental scope and context.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. In pressurized rat mesenteric arteries, raised potassium did not reliably reproduce acetylcholine-evoked EDHF relaxation or hyperpolarization.

    Potassium ion → Arteriolar dilation source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    Myogenic tone at 60/90 mmHg, nitric oxide and prostanoid pathways blocked.
    limitations
    Preparation and tone differ from earlier work; record scope rather than inventing an unexplained contradiction.
    nutrient_topic
    Potassium research collection; topical membership is not evidence of a direct dietary effect. · Potassium
    organism
    Rattus norvegicus
    plain_language
    Potassium is not a universal explanation for endothelial relaxation.
    primary_references
    [k-brochet2014] A comparison of responses to raised extracellular potassium and endothelium-derived hyperpolarizing factor (EDHF) in rat pressurised mesenteric arteries (2014). https://pubmed.ncbi.nlm.nih.gov/25372386/ DOI: 10.1371/journal.pone.0111977
    tissue_or_cell_type
    Mesenteric resistance arteries

    Potassium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 1627–1636

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Myogenic tone at 60/90 mmHg, nitric oxide and prostanoid pathways blocked. · source_derived_draft · unverified_draft

    ### k-vascular-edhf-context-boundary In pressurized rat mesenteric arteries, raised potassium did not reliably reproduce acetylcholine-evoked EDHF relaxation or hyperpolarization. Condition category: normal nutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Potassium is not a universal explanation for endothelial relaxation. organism: Rattus norvegicus tissue_or_cell_type: Mesenteric resistance arteries experimental_model: Myogenic tone at 60/90 mmHg, nitric oxide and prostanoid pathways blocked. limitations: Preparation and tone differ from earlier work; record scope rather than inventing an unexplained contradiction. [k-brochet2014] A comparison of responses to raised extracellular potassium and endothelium-derived hyperpolarizing factor (EDHF) in rat pressurised mesenteric arteries (2014). https://pubmed.ncbi.nlm.nih.gov/25372386/ DOI: 10.1371/journal.pone.0111977
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Local potassium stimulated Kir2.1-dependent capillary signaling; endothelial Kir2.1 deletion abolished the tested potassium-evoked upstream dilation.

    Potassium ion → KCNJ2 / Kir2.1 source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    Mouse isolated capillary-arteriole preparations and in-vivo imaging.
    exposure
    Local 10 mmol/L K application.
    limitations
    Local experimental potassium exposure, not dietary supplementation.
    nutrient_topic
    Potassium research collection; topical membership is not evidence of a direct dietary effect. · Potassium
    organism
    Mus musculus
    plain_language
    Brain capillaries can send an electrical signal upstream to their supplying arteriole.
    primary_references
    [k-longden2017] Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow (2017). https://pubmed.ncbi.nlm.nih.gov/28319610/ DOI: 10.1038/nn.4533
    tissue_or_cell_type
    Brain capillary endothelium and upstream arterioles

    Potassium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 1604–1614

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse isolated capillary-arteriole preparations and in-vivo imaging. · source_derived_draft · unverified_draft

    ### k-capillary-kir21-sensing Local potassium stimulated Kir2.1-dependent capillary signaling; endothelial Kir2.1 deletion abolished the tested potassium-evoked upstream dilation. Condition category: normal nutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Brain capillaries can send an electrical signal upstream to their supplying arteriole. organism: Mus musculus tissue_or_cell_type: Brain capillary endothelium and upstream arterioles experimental_model: Mouse isolated capillary-arteriole preparations and in-vivo imaging. limitations: Local experimental potassium exposure, not dietary supplementation. exposure: Local 10 mmol/L K application. [k-longden2017] Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow (2017). https://pubmed.ncbi.nlm.nih.gov/28319610/ DOI: 10.1038/nn.4533
    Complete structured claim and evidence

  2. Small extracellular potassium elevations relaxed the studied rat arteries through ouabain/barium-sensitive pump and inward-rectifier pathways.

    Potassium ion → Vascular smooth muscle hyperpolarization source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    Potassium/sodium pump and potassium channels -> vessel response.
    experimental_model
    Isolated rat artery electrophysiology.
    limitations
    Channel family inference; not every artery or potassium concentration responds this way.
    nutrient_topic
    Potassium research collection; topical membership is not evidence of a direct dietary effect. · Potassium
    organism
    Rattus norvegicus
    plain_language
    A modest local potassium rise can relax a vessel under particular conditions.
    primary_references
    [k-edwards1998] K+ is an endothelium-derived hyperpolarizing factor in rat arteries (1998). https://pubmed.ncbi.nlm.nih.gov/9834033/ DOI: 10.1038/24388
    tissue_or_cell_type
    Arterial smooth muscle

    Potassium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 1592–1602

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Isolated rat artery electrophysiology. · source_derived_draft · unverified_draft

    ### k-vascular-pump-kir-relaxation Small extracellular potassium elevations relaxed the studied rat arteries through ouabain/barium-sensitive pump and inward-rectifier pathways. Condition category: normal nutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect. plain_language: A modest local potassium rise can relax a vessel under particular conditions. organism: Rattus norvegicus tissue_or_cell_type: Arterial smooth muscle experimental_model: Isolated rat artery electrophysiology. limitations: Channel family inference; not every artery or potassium concentration responds this way. cross_nutrient: Potassium/sodium pump and potassium channels -> vessel response. [k-edwards1998] K+ is an endothelium-derived hyperpolarizing factor in rat arteries (1998). https://pubmed.ncbi.nlm.nih.gov/9834033/ DOI: 10.1038/24388
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards