{"id":"e120b480-2013-59ef-bcc7-7bbe518a89fa","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-vascular-pump-kir-relaxation","predicate":"local_increase_can_promote","statement":"Small extracellular potassium elevations relaxed the studied rat arteries through ouabain/barium-sensitive pump and inward-rectifier pathways.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9b594375-f2bf-571a-9d44-87cfa6fb99a6","mechanism_event_label":"A modest local potassium rise can relax a vessel under particular conditions.","subject":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"object":{"id":"3b49e4fc-d70c-5b07-8258-e46efb8df912","slug":"vascular-smooth-muscle-hyperpolarization","display_name":"Vascular smooth muscle hyperpolarization","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9b594375-f2bf-571a-9d44-87cfa6fb99a6","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-vascular-pump-kir-relaxation-event","event_type":"biochemical_relationship","label":"A modest local potassium rise can relax a vessel under particular conditions.","description":"Small extracellular potassium elevations relaxed the studied rat arteries through ouabain/barium-sensitive pump and inward-rectifier pathways.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"27c3e7bd-c6e1-5344-8130-b231a9da2cfb","slug":"sodium-potassium-atpase","display_name":"Sodium-potassium ATPase complexes","entity_type_key":"protein_family"},"role":"pump_dependency","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a9fc26db-2a2a-5725-b477-72abb21035cf","slug":"vascular-kir-channels","display_name":"Vascular inward-rectifier potassium channels","entity_type_key":"protein_family"},"role":"channel_dependency","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"12574c86-7d7d-5cab-8049-077a23637bcf","slug":"arteriolar-dilation","display_name":"Arteriolar dilation","entity_type_key":"cellular_process"},"role":"functional_response","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"3b49e4fc-d70c-5b07-8258-e46efb8df912","slug":"vascular-smooth-muscle-hyperpolarization","display_name":"Vascular smooth muscle hyperpolarization","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Potassium/sodium pump and potassium channels -> vessel response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Isolated rat artery electrophysiology.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Channel family inference; not every artery or potassium concentration responds this way.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A modest local potassium rise can relax a vessel under particular conditions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[k-edwards1998] K+ is an endothelium-derived hyperpolarizing factor in rat arteries (1998). https://pubmed.ncbi.nlm.nih.gov/9834033/ DOI: 10.1038/24388","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Arterial smooth muscle","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b98d2caf-e169-51ec-bcad-0b2eee9648b2","evidence_kind":"source_excerpt","locator":"Lines 1592-1602","start_line":1592,"end_line":1602,"excerpt":"### k-vascular-pump-kir-relaxation\nSmall extracellular potassium elevations relaxed the studied rat arteries through ouabain/barium-sensitive pump and inward-rectifier pathways.\nCondition category: normal\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A modest local potassium rise can relax a vessel under particular conditions.\norganism: Rattus norvegicus\ntissue_or_cell_type: Arterial smooth muscle\nexperimental_model: Isolated rat artery electrophysiology.\nlimitations: Channel family inference; not every artery or potassium concentration responds this way.\ncross_nutrient: Potassium/sodium pump and potassium channels -> vessel response.\n[k-edwards1998] K+ is an endothelium-derived hyperpolarizing factor in rat arteries (1998). https://pubmed.ncbi.nlm.nih.gov/9834033/ DOI: 10.1038/24388","model_system":"Isolated rat artery electrophysiology.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [k-edwards1998] K+ is an endothelium-derived hyperpolarizing factor in rat arteries (1998). https://pubmed.ncbi.nlm.nih.gov/9834033/ DOI: 10.1038/24388","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}