{"id":"7ef03d37-131e-591b-a689-e70d2f4e89fe","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-capillary-kir21-sensing","predicate":"activates_local_signaling_through","statement":"Local potassium stimulated Kir2.1-dependent capillary signaling; endothelial Kir2.1 deletion abolished the tested potassium-evoked upstream dilation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9b471ec8-6321-55a7-aebe-a1446a71385b","mechanism_event_label":"Brain capillaries can send an electrical signal upstream to their supplying arteriole.","subject":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"object":{"id":"416f3f9e-2f1f-5d0e-9650-628d3c0d05cb","slug":"kcnj2","display_name":"KCNJ2 / Kir2.1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"9b471ec8-6321-55a7-aebe-a1446a71385b","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-capillary-kir21-sensing-event","event_type":"biochemical_relationship","label":"Brain capillaries can send an electrical signal upstream to their supplying arteriole.","description":"Local potassium stimulated Kir2.1-dependent capillary signaling; endothelial Kir2.1 deletion abolished the tested potassium-evoked upstream dilation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3c4f58fa-d557-5f9d-8ed0-639a3e223bb7","slug":"capillary-endothelial-hyperpolarization","display_name":"Capillary endothelial hyperpolarization","entity_type_key":"cellular_process"},"role":"signal","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"12574c86-7d7d-5cab-8049-077a23637bcf","slug":"arteriolar-dilation","display_name":"Arteriolar dilation","entity_type_key":"cellular_process"},"role":"upstream_response","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"416f3f9e-2f1f-5d0e-9650-628d3c0d05cb","slug":"kcnj2","display_name":"KCNJ2 / Kir2.1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Mouse isolated capillary-arteriole preparations and in-vivo imaging.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Local 10 mmol/L K application.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Local experimental potassium exposure, not dietary supplementation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Brain capillaries can send an electrical signal upstream to their supplying arteriole.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[k-longden2017] Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow (2017). https://pubmed.ncbi.nlm.nih.gov/28319610/ DOI: 10.1038/nn.4533","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Brain capillary endothelium and upstream arterioles","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e4420e8f-b6e5-5f3a-a993-5c889bbb1603","evidence_kind":"source_excerpt","locator":"Lines 1604-1614","start_line":1604,"end_line":1614,"excerpt":"### k-capillary-kir21-sensing\nLocal potassium stimulated Kir2.1-dependent capillary signaling; endothelial Kir2.1 deletion abolished the tested potassium-evoked upstream dilation.\nCondition category: normal\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Brain capillaries can send an electrical signal upstream to their supplying arteriole.\norganism: Mus musculus\ntissue_or_cell_type: Brain capillary endothelium and upstream arterioles\nexperimental_model: Mouse isolated capillary-arteriole preparations and in-vivo imaging.\nlimitations: Local experimental potassium exposure, not dietary supplementation.\nexposure: Local 10 mmol/L K application.\n[k-longden2017] Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow (2017). https://pubmed.ncbi.nlm.nih.gov/28319610/ DOI: 10.1038/nn.4533","model_system":"Mouse isolated capillary-arteriole preparations and in-vivo imaging.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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