{"id":"aaf9bcd1-f96e-5b1e-83c3-9b8be5bf7d69","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-vascular-edhf-context-boundary","predicate":"does_not_universally_reproduce","statement":"In pressurized rat mesenteric arteries, raised potassium did not reliably reproduce acetylcholine-evoked EDHF relaxation or hyperpolarization.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"42f203bc-46f4-5b48-93b4-665f787e31eb","mechanism_event_label":"Potassium is not a universal explanation for endothelial relaxation.","subject":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"object":{"id":"12574c86-7d7d-5cab-8049-077a23637bcf","slug":"arteriolar-dilation","display_name":"Arteriolar dilation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"42f203bc-46f4-5b48-93b4-665f787e31eb","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-vascular-edhf-context-boundary-event","event_type":"biochemical_relationship","label":"Potassium is not a universal explanation for endothelial relaxation.","description":"In pressurized rat mesenteric arteries, raised potassium did not reliably reproduce acetylcholine-evoked EDHF relaxation or hyperpolarization.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3b49e4fc-d70c-5b07-8258-e46efb8df912","slug":"vascular-smooth-muscle-hyperpolarization","display_name":"Vascular smooth muscle hyperpolarization","entity_type_key":"cellular_process"},"role":"measured_response","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"12574c86-7d7d-5cab-8049-077a23637bcf","slug":"arteriolar-dilation","display_name":"Arteriolar dilation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Myogenic tone at 60/90 mmHg, nitric oxide and prostanoid pathways blocked.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Preparation and tone differ from earlier work; record scope rather than inventing an unexplained contradiction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Potassium is not a universal explanation for endothelial relaxation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[k-brochet2014] A comparison of responses to raised extracellular potassium and endothelium-derived hyperpolarizing factor (EDHF) in rat pressurised mesenteric arteries (2014). https://pubmed.ncbi.nlm.nih.gov/25372386/ DOI: 10.1371/journal.pone.0111977","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Mesenteric resistance arteries","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"aeb47358-6b49-5464-bc44-82342d6b1154","evidence_kind":"source_excerpt","locator":"Lines 1627-1636","start_line":1627,"end_line":1636,"excerpt":"### k-vascular-edhf-context-boundary\nIn pressurized rat mesenteric arteries, raised potassium did not reliably reproduce acetylcholine-evoked EDHF relaxation or hyperpolarization.\nCondition category: normal\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Potassium is not a universal explanation for endothelial relaxation.\norganism: Rattus norvegicus\ntissue_or_cell_type: Mesenteric resistance arteries\nexperimental_model: Myogenic tone at 60/90 mmHg, nitric oxide and prostanoid pathways blocked.\nlimitations: Preparation and tone differ from earlier work; record scope rather than inventing an unexplained contradiction.\n[k-brochet2014] A comparison of responses to raised extracellular potassium and endothelium-derived hyperpolarizing factor (EDHF) in rat pressurised mesenteric arteries (2014). https://pubmed.ncbi.nlm.nih.gov/25372386/ DOI: 10.1371/journal.pone.0111977","model_system":"Myogenic tone at 60/90 mmHg, nitric oxide and prostanoid pathways blocked.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [k-brochet2014] A comparison of responses to raised extracellular potassium and endothelium-derived hyperpolarizing factor (EDHF) in rat pressurised mesenteric arteries (2014). https://pubmed.ncbi.nlm.nih.gov/25372386/ DOI: 10.1371/journal.pone.0111977","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}