Component

All-cause mortality

All-cause mortality. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. All-cause mortality was 10% versus 18%, and cardiovascular mortality was 9% versus 16%, favoring CoQ in Q-SYMBIO.

    Coenzyme Q10 / CoQ10 redox system → All-cause mortality source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/coq10-research/25282031.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "20ff9f86de1fab16a33ecadfb2c4e09e9017860f01854cfecf490d473fb8fb65", "start_char": 0, "end_char": 2024, "text_sha256": "20ff9f86de1fab16a33ecadfb2c4e09e9017860f01854cfecf490d473fb8fb65"}
    experimental_model
    Q-SYMBIO randomized double-blind multicenter trial
    exposure
    100 mg CoQ10 three times daily added to standard therapy
    limitations
    One adjunctive-treatment trial; recruitment preceded current heart-failure regimens. Does not show universal benefit or replacement of standard treatment.
    nutrient_topic
    Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. · Coenzyme Q10 / CoQ10 redox system
    organism
    420 patients with moderate-to-severe chronic heart failure
    plain_language
    Mortality was a reported secondary outcome, separate from symptom markers.
    primary_references
    [coq10-p25282031] The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. (2014). https://pubmed.ncbi.nlm.nih.gov/25282031/ DOI: 10.1016/j.jchf.2014.06.008
    tissue_or_cell_type
    Short-term function and two-year clinical events

    Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17) · lines 1100–1111

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Q-SYMBIO randomized double-blind multicenter trial · source_derived_draft · unverified_draft

    ### coq10-heart-failure-mortality All-cause mortality was 10% versus 18%, and cardiovascular mortality was 9% versus 16%, favoring CoQ in Q-SYMBIO. Condition category: normal nutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Mortality was a reported secondary outcome, separate from symptom markers. organism: 420 patients with moderate-to-severe chronic heart failure tissue_or_cell_type: Short-term function and two-year clinical events experimental_model: Q-SYMBIO randomized double-blind multicenter trial limitations: One adjunctive-treatment trial; recruitment preceded current heart-failure regimens. Does not show universal benefit or replacement of standard treatment. exposure: 100 mg CoQ10 three times daily added to standard therapy evidence_span: {"source_cache": "artifacts/coq10-research/25282031.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "20ff9f86de1fab16a33ecadfb2c4e09e9017860f01854cfecf490d473fb8fb65", "start_char": 0, "end_char": 2024, "text_sha256": "20ff9f86de1fab16a33ecadfb2c4e09e9017860f01854cfecf490d473fb8fb65"} [coq10-p25282031] The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. (2014). https://pubmed.ncbi.nlm.nih.gov/25282031/ DOI: 10.1016/j.jchf.2014.06.008
    Complete structured claim and evidence

  2. Without adjustment the meta-analysis replicated the classic J-shaped curve with reduced mortality for low-volume drinkers (relative risk 0.86), but after adjustment for abstainer biases and study quality no significant reduction remained (relative risk 0.97), while former drinkers had elevated risk (1.22).

    Misclassification of former and occasional drinkers as abstainers → All-cause mortality source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/alcohol-research/26997174.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "db6a3810963367be7e87327becdf62060843fbd53c764a0d5c8f3d6c3084e9ec", "start_char": 0, "end_char": 2096, "text_sha256": "db6a3810963367be7e87327becdf62060843fbd53c764a0d5c8f3d6c3084e9ec"}
    experimental_model
    Systematic review and meta-regression of 87 studies, 3,998,626 people and 367,103 deaths
    exposure
    Alcohol consumption categories against all-cause mortality, adjusted for study quality
    limitations
    A bias-adjustment analysis. It does not report new participants; it reanalyses the existing cohorts after correcting how abstainers were defined.
    nutrient_topic
    Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. · Ethanol
    organism
    Human
    plain_language
    The apparent benefit of light drinking disappears once sick ex-drinkers are taken out of the comparison group.
    primary_references
    [alcohol-p26997174] Do "Moderate" Drinkers Have Reduced Mortality Risk? A Systematic Review and Meta-Analysis of Alcohol Consumption and All-Cause Mortality. (2016). https://pubmed.ncbi.nlm.nih.gov/26997174/ DOI: 10.15288/jsad.2016.77.185
    tissue_or_cell_type
    Whole body

    Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21) · lines 579–590

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Systematic review and meta-regression of 87 studies, 3,998,626 people and 367,103 deaths · source_derived_draft · unverified_draft

    ### alcohol-jcurve-artefact Without adjustment the meta-analysis replicated the classic J-shaped curve with reduced mortality for low-volume drinkers (relative risk 0.86), but after adjustment for abstainer biases and study quality no significant reduction remained (relative risk 0.97), while former drinkers had elevated risk (1.22). Condition category: normal nutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. plain_language: The apparent benefit of light drinking disappears once sick ex-drinkers are taken out of the comparison group. organism: Human tissue_or_cell_type: Whole body experimental_model: Systematic review and meta-regression of 87 studies, 3,998,626 people and 367,103 deaths limitations: A bias-adjustment analysis. It does not report new participants; it reanalyses the existing cohorts after correcting how abstainers were defined. exposure: Alcohol consumption categories against all-cause mortality, adjusted for study quality evidence_span: {"source_cache": "artifacts/alcohol-research/26997174.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "db6a3810963367be7e87327becdf62060843fbd53c764a0d5c8f3d6c3084e9ec", "start_char": 0, "end_char": 2096, "text_sha256": "db6a3810963367be7e87327becdf62060843fbd53c764a0d5c8f3d6c3084e9ec"} [alcohol-p26997174] Do "Moderate" Drinkers Have Reduced Mortality Risk? A Systematic Review and Meta-Analysis of Alcohol Consumption and All-Cause Mortality. (2016). https://pubmed.ncbi.nlm.nih.gov/26997174/ DOI: 10.15288/jsad.2016.77.185
    Complete structured claim and evidence

  3. In unadjusted models, protective effects were identified for alcohol consumption against all-cause mortality in pooled English cohorts of adults aged 50 and over, which the authors examine to test the suitability of age-specific limits.

    Habitual alcohol consumption → All-cause mortality source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/alcohol-research/25670624.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "2915b9b52e02cedee89d34376f15e2efc97c6a66e83377240892b305c0c5c1b8", "start_char": 0, "end_char": 3171, "text_sha256": "2915b9b52e02cedee89d34376f15e2efc97c6a66e83377240892b305c0c5c1b8"}
    experimental_model
    Pooled analysis of up to 10 population cohorts from the Health Survey for England
    exposure
    Self-reported weekly and heaviest-day consumption in adults aged 50 and over
    limitations
    A large observational cohort with the abstainer comparison the reanalysis above criticises. Protective effects were identified in unadjusted models.
    nutrient_topic
    Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. · Ethanol
    organism
    Human
    plain_language
    In the raw numbers, older people who drank moderately died less often.
    primary_references
    [alcohol-p25670624] All cause mortality and the case for age specific alcohol consumption guidelines: pooled analyses of up to 10 population based cohorts. (2015). https://pubmed.ncbi.nlm.nih.gov/25670624/ DOI: 10.1136/bmj.h384
    tissue_or_cell_type
    Whole body

    Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21) · lines 592–603

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Pooled analysis of up to 10 population cohorts from the Health Survey for England · source_derived_draft · unverified_draft

    ### alcohol-jcurve-observed In unadjusted models, protective effects were identified for alcohol consumption against all-cause mortality in pooled English cohorts of adults aged 50 and over, which the authors examine to test the suitability of age-specific limits. Condition category: normal nutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. plain_language: In the raw numbers, older people who drank moderately died less often. organism: Human tissue_or_cell_type: Whole body experimental_model: Pooled analysis of up to 10 population cohorts from the Health Survey for England limitations: A large observational cohort with the abstainer comparison the reanalysis above criticises. Protective effects were identified in unadjusted models. exposure: Self-reported weekly and heaviest-day consumption in adults aged 50 and over evidence_span: {"source_cache": "artifacts/alcohol-research/25670624.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "2915b9b52e02cedee89d34376f15e2efc97c6a66e83377240892b305c0c5c1b8", "start_char": 0, "end_char": 3171, "text_sha256": "2915b9b52e02cedee89d34376f15e2efc97c6a66e83377240892b305c0c5c1b8"} [alcohol-p25670624] All cause mortality and the case for age specific alcohol consumption guidelines: pooled analyses of up to 10 population based cohorts. (2015). https://pubmed.ncbi.nlm.nih.gov/25670624/ DOI: 10.1136/bmj.h384
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards