Component

Human beta-1 adrenergic receptor / ADRB1

Human beta-1 adrenergic receptor / ADRB1. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

Where it participates (unsigned role)

  1. All tested atenolol doses reduced nocturnal melatonin relative to placebo, with a dose-dependent pattern.

    Atenolol → Nocturnal circulating melatonin concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/melatonin-research/9406983.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7d3fe9b237757bb5797ed40bbc26931a04868f9160ea458dd1264671c77e0718", "start_char": 0, "end_char": 1175, "text_sha256": "7d3fe9b237757bb5797ed40bbc26931a04868f9160ea458dd1264671c77e0718"}
    experimental_model
    Randomized single-blind dose-response study
    exposure
    Atenolol 12.5, 25, 37.5 or 50 mg versus placebo; week washouts
    limitations
    Acute beta1 blockade and small sample. A lower concentration does not by itself establish symptomatic deficiency or a need for replacement.
    nutrient_topic
    Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
    organism
    Six healthy humans
    plain_language
    A medicine can weaken the normal secretion signal even when synthetic nutrients are available.
    primary_references
    [melatonin-p9406983] The effect of atenolol, a beta1-adrenergic antagonist, on nocturnal plasma melatonin secretion: evidence for a dose-response relationship in humans. (1997). https://pubmed.ncbi.nlm.nih.gov/9406983/ DOI: 10.1111/j.1600-079x.1997.tb00345.x
    tissue_or_cell_type
    Nocturnal melatonin secretion
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 968–979

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized single-blind dose-response study · source_derived_draft · unverified_draft

    ### melatonin-atenolol-suppression All tested atenolol doses reduced nocturnal melatonin relative to placebo, with a dose-dependent pattern. Condition category: machinery_impairment nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A medicine can weaken the normal secretion signal even when synthetic nutrients are available. organism: Six healthy humans tissue_or_cell_type: Nocturnal melatonin secretion experimental_model: Randomized single-blind dose-response study limitations: Acute beta1 blockade and small sample. A lower concentration does not by itself establish symptomatic deficiency or a need for replacement. exposure: Atenolol 12.5, 25, 37.5 or 50 mg versus placebo; week washouts evidence_span: {"source_cache": "artifacts/melatonin-research/9406983.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7d3fe9b237757bb5797ed40bbc26931a04868f9160ea458dd1264671c77e0718", "start_char": 0, "end_char": 1175, "text_sha256": "7d3fe9b237757bb5797ed40bbc26931a04868f9160ea458dd1264671c77e0718"} [melatonin-p9406983] The effect of atenolol, a beta1-adrenergic antagonist, on nocturnal plasma melatonin secretion: evidence for a dose-response relationship in humans. (1997). https://pubmed.ncbi.nlm.nih.gov/9406983/ DOI: 10.1111/j.1600-079x.1997.tb00345.x
    Complete structured claim and evidence

  2. UCP1 expression could be induced by any of the beta-1, beta-2 or beta-3 adrenergic receptor subtypes, but the greatest response came from stimulating all three simultaneously, and beta-3 stimulation did not prevent norepinephrine from further raising adenylyl cyclase activity, suggesting an additive cAMP response.

    Human beta-3 adrenergic receptor / ADRB3 → Human mitochondrial uncoupling protein 1 / UCP1 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/cold-research/7738011.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b1c5506f21f40d6674727a5fc3344f2b02f7fc9f2f1e911fd04bfecfc2399175", "start_char": 0, "end_char": 2592, "text_sha256": "b1c5506f21f40d6674727a5fc3344f2b02f7fc9f2f1e911fd04bfecfc2399175"}
    experimental_model
    Immortalized mouse brown adipocyte cell lines with selective beta-adrenergic agonists and antagonists
    exposure
    Norepinephrine, the beta-3 selective agonist CL316,243, and subtype-selective antagonists
    limitations
    A cell-line dissection of receptor subtypes. The additive cAMP response indicates the subtypes are not redundant, but these are immortalized cells.
    nutrient_topic
    Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Cold water immersion
    organism
    Mouse cell lines
    plain_language
    Three different receptors for the same messenger all feed the heat gene, and together they do more than any one alone.
    primary_references
    [cold-p7738011] Regulation of the uncoupling protein gene (Ucp) by beta 1, beta 2, and beta 3-adrenergic receptor subtypes in immortalized brown adipose cell lines. (1995). https://pubmed.ncbi.nlm.nih.gov/7738011/ DOI: 10.1074/jbc.270.18.10723
    tissue_or_cell_type
    Brown adipocytes

    Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19) · lines 364–375

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Immortalized mouse brown adipocyte cell lines with selective beta-adrenergic agonists and antagonists · source_derived_draft · unverified_draft

    ### cold-beta-receptors-ucp1 UCP1 expression could be induced by any of the beta-1, beta-2 or beta-3 adrenergic receptor subtypes, but the greatest response came from stimulating all three simultaneously, and beta-3 stimulation did not prevent norepinephrine from further raising adenylyl cyclase activity, suggesting an additive cAMP response. Condition category: normal nutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: Three different receptors for the same messenger all feed the heat gene, and together they do more than any one alone. organism: Mouse cell lines tissue_or_cell_type: Brown adipocytes experimental_model: Immortalized mouse brown adipocyte cell lines with selective beta-adrenergic agonists and antagonists limitations: A cell-line dissection of receptor subtypes. The additive cAMP response indicates the subtypes are not redundant, but these are immortalized cells. exposure: Norepinephrine, the beta-3 selective agonist CL316,243, and subtype-selective antagonists evidence_span: {"source_cache": "artifacts/cold-research/7738011.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b1c5506f21f40d6674727a5fc3344f2b02f7fc9f2f1e911fd04bfecfc2399175", "start_char": 0, "end_char": 2592, "text_sha256": "b1c5506f21f40d6674727a5fc3344f2b02f7fc9f2f1e911fd04bfecfc2399175"} [cold-p7738011] Regulation of the uncoupling protein gene (Ucp) by beta 1, beta 2, and beta 3-adrenergic receptor subtypes in immortalized brown adipose cell lines. (1995). https://pubmed.ncbi.nlm.nih.gov/7738011/ DOI: 10.1074/jbc.270.18.10723
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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