Component

7-Hydroxycoumarin glucuronide

7-Hydroxycoumarin glucuronide. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. The 7-hydroxycoumarin glucuronide was ineffective in the proliferation assays where parent and unconjugated metabolite were active.

    7-Hydroxycoumarin glucuronide → Proliferation of study-specified human malignant cell lines source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/coumarin-research/9583093.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dd691821bbdc859459d1373d8150a4579e13a0110f2d2bf1880cd895a99c5957", "start_char": 0, "end_char": 779, "text_sha256": "dd691821bbdc859459d1373d8150a4579e13a0110f2d2bf1880cd895a99c5957"}
    experimental_model
    Comparative proliferation assays of parent, hydroxylated and glucuronidated compound
    exposure
    Parent IC50 1.59–3.57 mM; 7-hydroxy metabolite IC50 0.68–2.69 mM
    limitations
    High in vitro concentrations; effects cannot be assumed at food exposure or across cell types.
    nutrient_topic
    Coumarin research collection; topical membership is not evidence of a direct dietary effect. · Coumarin
    organism
    Human cell lines
    plain_language
    Conjugation changed the measured biological effect.
    primary_references
    [coumarin-p9583093] Antitumor-activities of coumarin, 7-hydroxy-coumarin and its glucuronide in several human tumor cell lines. (1998). https://pubmed.ncbi.nlm.nih.gov/9583093/
    tissue_or_cell_type
    Gastric carcinoma, Caco-2, HepG2 and CCRF-CEM cells

    Coumarin: metabolism, signaling and nutrient connections (2026-09-17) · lines 462–473

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Comparative proliferation assays of parent, hydroxylated and glucuronidated compound · source_derived_draft · unverified_draft

    ### coumarin-glucuronide-null The 7-hydroxycoumarin glucuronide was ineffective in the proliferation assays where parent and unconjugated metabolite were active. Condition category: normal nutrient_topic: Coumarin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Conjugation changed the measured biological effect. organism: Human cell lines tissue_or_cell_type: Gastric carcinoma, Caco-2, HepG2 and CCRF-CEM cells experimental_model: Comparative proliferation assays of parent, hydroxylated and glucuronidated compound limitations: High in vitro concentrations; effects cannot be assumed at food exposure or across cell types. exposure: Parent IC50 1.59–3.57 mM; 7-hydroxy metabolite IC50 0.68–2.69 mM evidence_span: {"source_cache": "artifacts/coumarin-research/9583093.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dd691821bbdc859459d1373d8150a4579e13a0110f2d2bf1880cd895a99c5957", "start_char": 0, "end_char": 779, "text_sha256": "dd691821bbdc859459d1373d8150a4579e13a0110f2d2bf1880cd895a99c5957"} [coumarin-p9583093] Antitumor-activities of coumarin, 7-hydroxy-coumarin and its glucuronide in several human tumor cell lines. (1998). https://pubmed.ncbi.nlm.nih.gov/9583093/
    Complete structured claim and evidence

What acts on it

  1. 7-Hydroxycoumarin glucuronide was measured after oral coumarin, supporting extensive absorption and first-pass metabolism.

    Coumarin → 7-Hydroxycoumarin glucuronide source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/coumarin-research/7263928.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a0e89cd9655c11d4758646e8e40305b497ba72eef60100f660deaa87390cd385", "start_char": 0, "end_char": 1084, "text_sha256": "a0e89cd9655c11d4758646e8e40305b497ba72eef60100f660deaa87390cd385"}
    experimental_model
    Pilot oral, sustained-release and intravenous pharmacokinetic comparison
    exposure
    Coumarin formulations; full dosing not specified in abstract
    limitations
    Pilot formulation comparison; low parent exposure does not imply poor intestinal absorption.
    nutrient_topic
    Coumarin research collection; topical membership is not evidence of a direct dietary effect. · Coumarin
    organism
    Human
    plain_language
    The conjugated metabolite records processing of the swallowed compound.
    primary_references
    [coumarin-p7263928] Pilot study on bioavailability of coumarin and 7-hydroxycoumarin upon peroral administration of coumarin in a sustained-release dosage form. (1981). https://pubmed.ncbi.nlm.nih.gov/7263928/ DOI: 10.1002/j.1552-4604.1981.tb01770.x
    tissue_or_cell_type
    Whole blood

    Coumarin: metabolism, signaling and nutrient connections (2026-09-17) · lines 657–668

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Pilot oral, sustained-release and intravenous pharmacokinetic comparison · source_derived_draft · unverified_draft

    ### coumarin-human-glucuronide 7-Hydroxycoumarin glucuronide was measured after oral coumarin, supporting extensive absorption and first-pass metabolism. Condition category: normal nutrient_topic: Coumarin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The conjugated metabolite records processing of the swallowed compound. organism: Human tissue_or_cell_type: Whole blood experimental_model: Pilot oral, sustained-release and intravenous pharmacokinetic comparison limitations: Pilot formulation comparison; low parent exposure does not imply poor intestinal absorption. exposure: Coumarin formulations; full dosing not specified in abstract evidence_span: {"source_cache": "artifacts/coumarin-research/7263928.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a0e89cd9655c11d4758646e8e40305b497ba72eef60100f660deaa87390cd385", "start_char": 0, "end_char": 1084, "text_sha256": "a0e89cd9655c11d4758646e8e40305b497ba72eef60100f660deaa87390cd385"} [coumarin-p7263928] Pilot study on bioavailability of coumarin and 7-hydroxycoumarin upon peroral administration of coumarin in a sustained-release dosage form. (1981). https://pubmed.ncbi.nlm.nih.gov/7263928/ DOI: 10.1002/j.1552-4604.1981.tb01770.x
    Complete structured claim and evidence

  2. Bovine liver UGT preparation converted 7-hydroxycoumarin and UDP-glucuronic acid into its glucuronide.

    Bovine liver UDP-glucuronosyltransferase preparation; isoforms unresolved → 7-Hydroxycoumarin glucuronide source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/coumarin-research/8877866.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8092618f6e2773ad94670c810fb44af7c2acedc0680674872af23af8bc55e26d", "start_char": 0, "end_char": 2114, "text_sha256": "8092618f6e2773ad94670c810fb44af7c2acedc0680674872af23af8bc55e26d"}
    experimental_model
    Enzyme assay and HPLC metabolite identification
    exposure
    7-Hydroxycoumarin plus UDP-glucuronic acid
    limitations
    Bovine preparation does not identify a dominant human UGT isoform.
    nutrient_topic
    Coumarin research collection; topical membership is not evidence of a direct dietary effect. · Coumarin
    organism
    Bovine
    plain_language
    A sugar-acid donor enables the conjugation step.
    primary_references
    [coumarin-p8877866] Analysis of the glucuronidation of 7-hydroxycoumarin by HPLC. (1996). https://pubmed.ncbi.nlm.nih.gov/8877866/ DOI: 10.1016/0731-7085(96)01801-8
    tissue_or_cell_type
    Liver homogenate/crude UGT preparation

    Coumarin: metabolism, signaling and nutrient connections (2026-09-17) · lines 540–551

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Enzyme assay and HPLC metabolite identification · source_derived_draft · unverified_draft

    ### coumarin-ugt-conjugation Bovine liver UGT preparation converted 7-hydroxycoumarin and UDP-glucuronic acid into its glucuronide. Condition category: normal nutrient_topic: Coumarin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A sugar-acid donor enables the conjugation step. organism: Bovine tissue_or_cell_type: Liver homogenate/crude UGT preparation experimental_model: Enzyme assay and HPLC metabolite identification limitations: Bovine preparation does not identify a dominant human UGT isoform. exposure: 7-Hydroxycoumarin plus UDP-glucuronic acid evidence_span: {"source_cache": "artifacts/coumarin-research/8877866.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8092618f6e2773ad94670c810fb44af7c2acedc0680674872af23af8bc55e26d", "start_char": 0, "end_char": 2114, "text_sha256": "8092618f6e2773ad94670c810fb44af7c2acedc0680674872af23af8bc55e26d"} [coumarin-p8877866] Analysis of the glucuronidation of 7-hydroxycoumarin by HPLC. (1996). https://pubmed.ncbi.nlm.nih.gov/8877866/ DOI: 10.1016/0731-7085(96)01801-8
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards