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(1981). https://pubmed.ncbi.nlm.nih.gov/7263928/ DOI: 10.1002/j.1552-4604.1981.tb01770.x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Whole blood","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"011e3384-aea6-58f4-9fbe-d5684c49e858","evidence_kind":"source_excerpt","locator":"Lines 657-668","start_line":657,"end_line":668,"excerpt":"### coumarin-human-glucuronide\n7-Hydroxycoumarin glucuronide was measured after oral coumarin, supporting extensive absorption and first-pass metabolism.\nCondition category: normal\nnutrient_topic: Coumarin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The conjugated metabolite records processing of the swallowed compound.\norganism: Human\ntissue_or_cell_type: Whole blood\nexperimental_model: Pilot oral, sustained-release and intravenous pharmacokinetic comparison\nlimitations: Pilot formulation comparison; low parent exposure does not imply poor intestinal absorption.\nexposure: Coumarin formulations; full dosing not specified in abstract\nevidence_span: {\"source_cache\": \"artifacts/coumarin-research/7263928.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a0e89cd9655c11d4758646e8e40305b497ba72eef60100f660deaa87390cd385\", \"start_char\": 0, \"end_char\": 1084, \"text_sha256\": \"a0e89cd9655c11d4758646e8e40305b497ba72eef60100f660deaa87390cd385\"}\n[coumarin-p7263928] Pilot study on bioavailability of coumarin and 7-hydroxycoumarin upon peroral administration of coumarin in a sustained-release dosage form. 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