Component
Warfarin dose required to maintain anticoagulation
Warfarin dose required to maintain anticoagulation. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
INR remained stable and mean warfarin dose did not change significantly during CoQ versus placebo periods.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/coq10-research/12772396.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0c668036863182db6c07a131179cd78f773088609808e320fdee5fe34d2d9d14", "start_char": 0, "end_char": 1260, "text_sha256": "0c668036863182db6c07a131179cd78f773088609808e320fdee5fe34d2d9d14"}
- experimental_model
- Randomized double-blind placebo-controlled crossover trial
- exposure
- CoQ10 100 mg/day for four weeks; separate ginkgo and placebo periods
- limitations
- Small short trial with dose adjustment to maintain INR. Same trial was reported in a 2002 letter; not independent replication.
- nutrient_topic
- Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. · Coenzyme Q10 / CoQ10 redox system
- organism
- 24 stable warfarin-treated outpatients; three withdrawals
- plain_language
- A small controlled study did not demonstrate the interaction reported in cases.
- primary_references
- [coq10-p12772396] [Effect of Coenzyme Q10 and Ginkgo biloba on warfarin dosage in patients on long-term warfarin treatment. A randomized, double-blind, placebo-controlled cross-over trial]. (2003). https://pubmed.ncbi.nlm.nih.gov/12772396/
- tissue_or_cell_type
- INR and adjusted weekly warfarin dose
Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17) · lines 1269–1280
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind placebo-controlled crossover trial · source_derived_draft · unverified_draft
### coq10-warfarin-trial INR remained stable and mean warfarin dose did not change significantly during CoQ versus placebo periods. Condition category: normal nutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. plain_language: A small controlled study did not demonstrate the interaction reported in cases. organism: 24 stable warfarin-treated outpatients; three withdrawals tissue_or_cell_type: INR and adjusted weekly warfarin dose experimental_model: Randomized double-blind placebo-controlled crossover trial limitations: Small short trial with dose adjustment to maintain INR. Same trial was reported in a 2002 letter; not independent replication. exposure: CoQ10 100 mg/day for four weeks; separate ginkgo and placebo periods evidence_span: {"source_cache": "artifacts/coq10-research/12772396.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0c668036863182db6c07a131179cd78f773088609808e320fdee5fe34d2d9d14", "start_char": 0, "end_char": 1260, "text_sha256": "0c668036863182db6c07a131179cd78f773088609808e320fdee5fe34d2d9d14"} [coq10-p12772396] [Effect of Coenzyme Q10 and Ginkgo biloba on warfarin dosage in patients on long-term warfarin treatment. A randomized, double-blind, placebo-controlled cross-over trial]. (2003). https://pubmed.ncbi.nlm.nih.gov/12772396/
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.