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(2003). https://pubmed.ncbi.nlm.nih.gov/12772396/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"INR and adjusted weekly warfarin dose","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5d7020d6-e164-5969-8541-4e5159dcde30","evidence_kind":"source_excerpt","locator":"Lines 1269-1280","start_line":1269,"end_line":1280,"excerpt":"### coq10-warfarin-trial\nINR remained stable and mean warfarin dose did not change significantly during CoQ versus placebo periods.\nCondition category: normal\nnutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A small controlled study did not demonstrate the interaction reported in cases.\norganism: 24 stable warfarin-treated outpatients; three withdrawals\ntissue_or_cell_type: INR and adjusted weekly warfarin dose\nexperimental_model: Randomized double-blind placebo-controlled crossover trial\nlimitations: Small short trial with dose adjustment to maintain INR. Same trial was reported in a 2002 letter; not independent replication.\nexposure: CoQ10 100 mg/day for four weeks; separate ginkgo and placebo periods\nevidence_span: {\"source_cache\": \"artifacts/coq10-research/12772396.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0c668036863182db6c07a131179cd78f773088609808e320fdee5fe34d2d9d14\", \"start_char\": 0, \"end_char\": 1260, \"text_sha256\": \"0c668036863182db6c07a131179cd78f773088609808e320fdee5fe34d2d9d14\"}\n[coq10-p12772396] [Effect of Coenzyme Q10 and Ginkgo biloba on warfarin dosage in patients on long-term warfarin treatment. A randomized, double-blind, placebo-controlled cross-over trial]. 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