Component

Vitamin D2 and D3

Two vitamin forms feed a regulated hormone system. Follow their activation, cellular responses, and links to calcium, phosphate and magnesium. D2, D3, their metabolites and blood measurements have separate records. Combined nutritional chapter covering ergocalciferol and cholecalciferol; chemically distinct metabolites remain separate.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

Where it participates (unsigned role)

  1. The Clcn5-null model lost 25-hydroxyvitamin D3 in urine.

    Mouse ClC-5 chloride/proton exchanger / Clcn5 → Urinary loss of 25-hydroxyvitamin D3 source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/chloride-research/11099045.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4929ed9da0f3702bbd28bf679f79c2dfb13b4e81d23e44327b27bebdcf3a7cca", "start_char": 0, "end_char": 1218, "text_sha256": "4929ed9da0f3702bbd28bf679f79c2dfb13b4e81d23e44327b27bebdcf3a7cca"}
    experimental_model
    Clcn5 knockout and uptake measurements
    exposure
    Clcn5 disruption
    limitations
    The PTH/vitamin-D/hypercalciuria explanation includes proposed downstream steps; do not treat every link as demonstrated.
    nutrient_topic
    Chloride research collection; topical membership is not evidence of a direct dietary effect. · Chloride
    organism
    Mouse
    plain_language
    The transporter defect connects chloride machinery to vitamin D handling.
    primary_references
    [chloride-p11099045] ClC-5 Cl- -channel disruption impairs endocytosis in a mouse model for Dent's disease. (2000). https://pubmed.ncbi.nlm.nih.gov/11099045/ DOI: 10.1038/35042597
    tissue_or_cell_type
    Proximal renal tubule
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Chloride: transport, acid-base balance, nutrient interactions and loss states (2026-09-17) · lines 692–703

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Clcn5 knockout and uptake measurements · source_derived_draft · unverified_draft

    ### chloride-clc5-vitd-loss The Clcn5-null model lost 25-hydroxyvitamin D3 in urine. Condition category: machinery_impairment nutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect. plain_language: The transporter defect connects chloride machinery to vitamin D handling. organism: Mouse tissue_or_cell_type: Proximal renal tubule experimental_model: Clcn5 knockout and uptake measurements limitations: The PTH/vitamin-D/hypercalciuria explanation includes proposed downstream steps; do not treat every link as demonstrated. exposure: Clcn5 disruption evidence_span: {"source_cache": "artifacts/chloride-research/11099045.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4929ed9da0f3702bbd28bf679f79c2dfb13b4e81d23e44327b27bebdcf3a7cca", "start_char": 0, "end_char": 1218, "text_sha256": "4929ed9da0f3702bbd28bf679f79c2dfb13b4e81d23e44327b27bebdcf3a7cca"} [chloride-p11099045] ClC-5 Cl- -channel disruption impairs endocytosis in a mouse model for Dent's disease. (2000). https://pubmed.ncbi.nlm.nih.gov/11099045/ DOI: 10.1038/35042597
    Complete structured claim and evidence

  2. dp-ucMGP changed by -212 pmol/L with MK-7 plus vitamin D versus +45 pmol/L with placebo.

    Menaquinone-7 / MK-7 → Dephosphorylated uncarboxylated matrix Gla protein source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/k2-research/35465686.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0bd565b58d0e78923a55d154f6a341de560d5674c63989d36042543e0ddc295c", "start_char": 0, "end_char": 2233, "text_sha256": "0bd565b58d0e78923a55d154f6a341de560d5674c63989d36042543e0ddc295c"}
    experimental_model
    Two-year randomized double-blind AVADEC trial
    exposure
    MK-7 720 micrograms plus vitamin D 25 micrograms/day versus placebo
    limitations
    Combined intervention, valve-disease population; neither K2-only effects nor universal prevention claims follow.
    nutrient_topic
    Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
    organism
    365 men, mean age 71, with aortic-valve calcium score above 300
    plain_language
    A biochemical response coexisted with a null valve-imaging result.
    primary_references
    [k2-p35465686] Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial. (2022). https://pubmed.ncbi.nlm.nih.gov/35465686/ DOI: 10.1161/circulationaha.121.057008
    tissue_or_cell_type
    Valve CT, echocardiography and dp-ucMGP

    Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 1215–1226

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Two-year randomized double-blind AVADEC trial · source_derived_draft · unverified_draft

    ### k2-avadec-marker dp-ucMGP changed by -212 pmol/L with MK-7 plus vitamin D versus +45 pmol/L with placebo. Condition category: normal nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: A biochemical response coexisted with a null valve-imaging result. organism: 365 men, mean age 71, with aortic-valve calcium score above 300 tissue_or_cell_type: Valve CT, echocardiography and dp-ucMGP experimental_model: Two-year randomized double-blind AVADEC trial limitations: Combined intervention, valve-disease population; neither K2-only effects nor universal prevention claims follow. exposure: MK-7 720 micrograms plus vitamin D 25 micrograms/day versus placebo evidence_span: {"source_cache": "artifacts/k2-research/35465686.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0bd565b58d0e78923a55d154f6a341de560d5674c63989d36042543e0ddc295c", "start_char": 0, "end_char": 2233, "text_sha256": "0bd565b58d0e78923a55d154f6a341de560d5674c63989d36042543e0ddc295c"} [k2-p35465686] Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial. (2022). https://pubmed.ncbi.nlm.nih.gov/35465686/ DOI: 10.1161/circulationaha.121.057008
    Complete structured claim and evidence

  3. MK-7 plus vitamin D did not significantly change aortic-valve calcification progression versus placebo over two years (P=0.64).

    Menaquinone-7 / MK-7 → Aortic valve calcification source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/k2-research/35465686.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0bd565b58d0e78923a55d154f6a341de560d5674c63989d36042543e0ddc295c", "start_char": 0, "end_char": 2233, "text_sha256": "0bd565b58d0e78923a55d154f6a341de560d5674c63989d36042543e0ddc295c"}
    experimental_model
    Two-year randomized double-blind AVADEC trial
    exposure
    MK-7 720 micrograms plus vitamin D 25 micrograms/day versus placebo
    limitations
    Combined intervention, valve-disease population; neither K2-only effects nor universal prevention claims follow.
    nutrient_topic
    Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
    organism
    365 men, mean age 71, with aortic-valve calcium score above 300
    plain_language
    The combination did not slow the valve endpoint in these men.
    primary_references
    [k2-p35465686] Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial. (2022). https://pubmed.ncbi.nlm.nih.gov/35465686/ DOI: 10.1161/circulationaha.121.057008
    tissue_or_cell_type
    Valve CT, echocardiography and dp-ucMGP

    Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 1202–1213

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Two-year randomized double-blind AVADEC trial · source_derived_draft · unverified_draft

    ### k2-avadec-null MK-7 plus vitamin D did not significantly change aortic-valve calcification progression versus placebo over two years (P=0.64). Condition category: normal nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The combination did not slow the valve endpoint in these men. organism: 365 men, mean age 71, with aortic-valve calcium score above 300 tissue_or_cell_type: Valve CT, echocardiography and dp-ucMGP experimental_model: Two-year randomized double-blind AVADEC trial limitations: Combined intervention, valve-disease population; neither K2-only effects nor universal prevention claims follow. exposure: MK-7 720 micrograms plus vitamin D 25 micrograms/day versus placebo evidence_span: {"source_cache": "artifacts/k2-research/35465686.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0bd565b58d0e78923a55d154f6a341de560d5674c63989d36042543e0ddc295c", "start_char": 0, "end_char": 2233, "text_sha256": "0bd565b58d0e78923a55d154f6a341de560d5674c63989d36042543e0ddc295c"} [k2-p35465686] Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial. (2022). https://pubmed.ncbi.nlm.nih.gov/35465686/ DOI: 10.1161/circulationaha.121.057008
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards