Component
Aortic valve calcification
Aortic valve calcification. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
MK-7 plus vitamin D did not significantly change aortic-valve calcification progression versus placebo over two years (P=0.64).
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/k2-research/35465686.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0bd565b58d0e78923a55d154f6a341de560d5674c63989d36042543e0ddc295c", "start_char": 0, "end_char": 2233, "text_sha256": "0bd565b58d0e78923a55d154f6a341de560d5674c63989d36042543e0ddc295c"}
- experimental_model
- Two-year randomized double-blind AVADEC trial
- exposure
- MK-7 720 micrograms plus vitamin D 25 micrograms/day versus placebo
- limitations
- Combined intervention, valve-disease population; neither K2-only effects nor universal prevention claims follow.
- nutrient_topic
- Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
- organism
- 365 men, mean age 71, with aortic-valve calcium score above 300
- plain_language
- The combination did not slow the valve endpoint in these men.
- primary_references
- [k2-p35465686] Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial. (2022). https://pubmed.ncbi.nlm.nih.gov/35465686/ DOI: 10.1161/circulationaha.121.057008
- tissue_or_cell_type
- Valve CT, echocardiography and dp-ucMGP
Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 1202–1213
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Two-year randomized double-blind AVADEC trial · source_derived_draft · unverified_draft
### k2-avadec-null MK-7 plus vitamin D did not significantly change aortic-valve calcification progression versus placebo over two years (P=0.64). Condition category: normal nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The combination did not slow the valve endpoint in these men. organism: 365 men, mean age 71, with aortic-valve calcium score above 300 tissue_or_cell_type: Valve CT, echocardiography and dp-ucMGP experimental_model: Two-year randomized double-blind AVADEC trial limitations: Combined intervention, valve-disease population; neither K2-only effects nor universal prevention claims follow. exposure: MK-7 720 micrograms plus vitamin D 25 micrograms/day versus placebo evidence_span: {"source_cache": "artifacts/k2-research/35465686.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0bd565b58d0e78923a55d154f6a341de560d5674c63989d36042543e0ddc295c", "start_char": 0, "end_char": 2233, "text_sha256": "0bd565b58d0e78923a55d154f6a341de560d5674c63989d36042543e0ddc295c"} [k2-p35465686] Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial. (2022). https://pubmed.ncbi.nlm.nih.gov/35465686/ DOI: 10.1161/circulationaha.121.057008
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.