Component
Tyrosol
Species, preparation, dose and limitations are retained on linked claims.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
After beer or red wine in 20 adults, urinary recovery supported tyrosol-to-hydroxytyrosol conversion, and the conversion ratio tracked CYP2A6/CYP2D6 activity score, sex and beverage matrix.
Experimental context and source evidence
- dose
- Red wine, IPA, blonde beer or non-alcoholic beer
- duration
- Single-dose crossover
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- Twenty healthy adults in a randomized crossover trial
- limitations
- Alcohol and beverage constituents are co-exposures; the study does not justify alcohol consumption for hydroxytyrosol production.
- nutrient_topic
- Hydroxytyrosol chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Hydroxytyrosol
- organism
- Twenty healthy adults in a randomized crossover trial
- plain_language
- After beer or red wine in 20 adults, urinary recovery supported tyrosol-to-hydroxytyrosol conversion, and the conversion ratio tracked CYP2A6/CYP2D6 activity score, sex and beverage matrix.
- primary_references
- Generation of the Antioxidant Hydroxytyrosol from Tyrosol Present in Beer and Red Wine in a Randomized Clinical Trial. (2019). https://pubmed.ncbi.nlm.nih.gov/31540384/ DOI: 10.3390/nu11092241
- route
- Oral beverage
- tissue
- Tyrosol and hydroxytyrosol recovery with genotype score
Hydroxytyrosol: mechanism of action and interactions (2026-09-20) · lines 55–64
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Twenty healthy adults in a randomized crossover trial · source_derived_draft · unverified_draft
## hydroxytyrosol-human-tyrosol-conversion After beer or red wine in 20 adults, urinary recovery supported tyrosol-to-hydroxytyrosol conversion, and the conversion ratio tracked CYP2A6/CYP2D6 activity score, sex and beverage matrix. Model/species: Twenty healthy adults in a randomized crossover trial Tissue/system: Tyrosol and hydroxytyrosol recovery with genotype score Exposure: Red wine, IPA, blonde beer or non-alcoholic beer Route: Oral beverage Duration: Single-dose crossover Limits: Alcohol and beverage constituents are co-exposures; the study does not justify alcohol consumption for hydroxytyrosol production. Primary reference: Generation of the Antioxidant Hydroxytyrosol from Tyrosol Present in Beer and Red Wine in a Randomized Clinical Trial. (2019). https://pubmed.ncbi.nlm.nih.gov/31540384/ DOI: 10.3390/nu11092241 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidenceHuman liver microsomes and recombinant enzymes converted tyrosol to hydroxytyrosol, with CYP2A6 and CYP2D6 supported as major contributors and CYP3A4 also active in baculosomes.
Experimental context and source evidence
- dose
- Tyrosol with selective CYP inhibitors or recombinant enzymes
- duration
- Enzyme incubation
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- Human liver microsomes, recombinant CYPs, genotyped livers and rat control experiments
- limitations
- Relative contribution varies by genotype and setting; this does not make every tyrosol food equivalent to hydroxytyrosol dosing.
- nutrient_topic
- Hydroxytyrosol chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Hydroxytyrosol
- organism
- Human liver microsomes, recombinant CYPs, genotyped livers and rat control experiments
- plain_language
- Human liver microsomes and recombinant enzymes converted tyrosol to hydroxytyrosol, with CYP2A6 and CYP2D6 supported as major contributors and CYP3A4 also active in baculosomes.
- primary_references
- CYP2D6 and CYP2A6 biotransform dietary tyrosol into hydroxytyrosol. (2017). https://pubmed.ncbi.nlm.nih.gov/27664690/ DOI: 10.1016/j.foodchem.2016.09.026
- route
- In vitro and in vivo experimental metabolism
- tissue
- Tyrosol hydroxylation
Hydroxytyrosol: mechanism of action and interactions (2026-09-20) · lines 44–53
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Human liver microsomes, recombinant CYPs, genotyped livers and rat control experiments · source_derived_draft · unverified_draft
## hydroxytyrosol-tyrosol-cyp-conversion Human liver microsomes and recombinant enzymes converted tyrosol to hydroxytyrosol, with CYP2A6 and CYP2D6 supported as major contributors and CYP3A4 also active in baculosomes. Model/species: Human liver microsomes, recombinant CYPs, genotyped livers and rat control experiments Tissue/system: Tyrosol hydroxylation Exposure: Tyrosol with selective CYP inhibitors or recombinant enzymes Route: In vitro and in vivo experimental metabolism Duration: Enzyme incubation Limits: Relative contribution varies by genotype and setting; this does not make every tyrosol food equivalent to hydroxytyrosol dosing. Primary reference: CYP2D6 and CYP2A6 biotransform dietary tyrosol into hydroxytyrosol. (2017). https://pubmed.ncbi.nlm.nih.gov/27664690/ DOI: 10.1016/j.foodchem.2016.09.026 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.