{"id":"2630bd85-ee28-5dbe-97cd-3abf98e963d0","stable_key":"cb41aa31-e26b-5b60-b7e0-e4985fb7aea8:hydroxytyrosol-human-tyrosol-conversion","predicate":"is_converted_in_humans_to","statement":"After beer or red wine in 20 adults, urinary recovery supported tyrosol-to-hydroxytyrosol conversion, and the conversion ratio tracked CYP2A6/CYP2D6 activity score, sex and beverage matrix.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"08ff2844-eb0c-5f99-a230-8e240ec38140","mechanism_event_label":"After beer or red wine in 20 adults, urinary recovery supported tyrosol-to-hydroxytyrosol conversion, and the conversion ratio tracked CYP2A6/CYP2D6 activity score, sex and beverage matrix.","subject":{"id":"677d24bc-5068-58d2-a9fb-91610c5f1983","slug":"tyrosol","display_name":"Tyrosol","entity_type_key":"small_molecule"},"object":{"id":"45a7aaec-8acc-5d5a-a014-c483ef5385e2","slug":"hydroxytyrosol","display_name":"Hydroxytyrosol","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"08ff2844-eb0c-5f99-a230-8e240ec38140","stable_key":"cb41aa31-e26b-5b60-b7e0-e4985fb7aea8:hydroxytyrosol-human-tyrosol-conversion-event","event_type":"observed_relationship","label":"After beer or red wine in 20 adults, urinary recovery supported tyrosol-to-hydroxytyrosol conversion, and the conversion ratio tracked CYP2A6/CYP2D6 activity score, sex and beverage matrix.","description":"After beer or red wine in 20 adults, urinary recovery supported tyrosol-to-hydroxytyrosol conversion, and the conversion ratio tracked CYP2A6/CYP2D6 activity score, sex and beverage matrix.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"677d24bc-5068-58d2-a9fb-91610c5f1983","slug":"tyrosol","display_name":"Tyrosol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"45a7aaec-8acc-5d5a-a014-c483ef5385e2","slug":"hydroxytyrosol","display_name":"Hydroxytyrosol","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"44b7b150-3615-5d52-9db8-beb212fc31eb","slug":"cyp2a6","display_name":"Human cytochrome P450 2A6 / CYP2A6","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"10f7a103-d63d-5bf4-8384-c5e1308ce126","slug":"cyp2d6","display_name":"Human cytochrome P450 2D6","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Red wine, IPA, blonde beer or non-alcoholic beer","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Single-dose crossover","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Twenty healthy adults in a randomized crossover trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Alcohol and beverage constituents are co-exposures; the study does not justify alcohol consumption for hydroxytyrosol production.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Hydroxytyrosol chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"hydroxytyrosol","display_name":"Hydroxytyrosol","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Twenty healthy adults in a randomized crossover trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"After beer or red wine in 20 adults, urinary recovery supported tyrosol-to-hydroxytyrosol conversion, and the conversion ratio tracked CYP2A6/CYP2D6 activity score, sex and beverage matrix.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Generation of the Antioxidant Hydroxytyrosol from Tyrosol Present in Beer and Red Wine in a Randomized Clinical Trial. (2019). https://pubmed.ncbi.nlm.nih.gov/31540384/ DOI: 10.3390/nu11092241","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral beverage","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Tyrosol and hydroxytyrosol recovery with genotype score","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"46e2d384-2c74-545f-98f7-c080f4e8e313","evidence_kind":"source_excerpt","locator":"Lines 55-64","start_line":55,"end_line":64,"excerpt":"## hydroxytyrosol-human-tyrosol-conversion\nAfter beer or red wine in 20 adults, urinary recovery supported tyrosol-to-hydroxytyrosol conversion, and the conversion ratio tracked CYP2A6/CYP2D6 activity score, sex and beverage matrix.\nModel/species: Twenty healthy adults in a randomized crossover trial\nTissue/system: Tyrosol and hydroxytyrosol recovery with genotype score\nExposure: Red wine, IPA, blonde beer or non-alcoholic beer\nRoute: Oral beverage\nDuration: Single-dose crossover\nLimits: Alcohol and beverage constituents are co-exposures; the study does not justify alcohol consumption for hydroxytyrosol production.\nPrimary reference: Generation of the Antioxidant Hydroxytyrosol from Tyrosol Present in Beer and Red Wine in a Randomized Clinical Trial. (2019). https://pubmed.ncbi.nlm.nih.gov/31540384/ DOI: 10.3390/nu11092241\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Twenty healthy adults in a randomized crossover trial","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"f83cd982-34f0-55d4-8563-eedfb0f009f2","stable_key":"import-cb41aa31-e26b-5b60-b7e0-e4985fb7aea8","title":"Hydroxytyrosol: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text.","file_path":"","sha256":"7677fedffc16af238fc1ace3f88d206dd42b29b163c40b6e69ba6ed2457a3aee","revision_id":"1e0bd617-6834-5a2d-a74e-c058967d99b7","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}