Component
TXNRD3
Independent protein record for Thioredoxin glutathione reductase.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Male Txnrd3-knockout mice showed impaired reproductive performance and reduced fertilization in the reported assays.
Experimental context and source evidence
- experimental_model
- Txnrd3-knockout mice, sperm thiol assays and in-vitro fertilization.
- limitations
- This experiment-specific relationship does not establish a human dietary-deficiency threshold or supplementation benefit.
- organism
- Mouse
Selenium: literature corrections and mechanism additions · lines 987–996
Metabolic Ledger literature curation, 17 September 2026; primary papers linked individually · supports · Txnrd3-knockout mice, sperm thiol assays and in-vitro fertilization. · secondary_verified · secondary_verified
## txnrd3-mouse-fertility Removing TXNRD3 impaired fertility in the studied mice. Male Txnrd3-knockout mice showed impaired reproductive performance and reduced fertilization in the reported assays. Experimental model: Txnrd3-knockout mice, sperm thiol assays and in-vitro fertilization. Organism: Mouse Limitations: This experiment-specific relationship does not establish a human dietary-deficiency threshold or supplementation benefit. Primary reference: [Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis](https://pmc.ncbi.nlm.nih.gov/articles/PMC9352919/)
Complete structured claim and evidenceTxnrd3 deletion in mice altered sperm protein thiol status, supporting a role for TXNRD3 in sperm redox remodeling.
Experimental context and source evidence
- experimental_model
- Txnrd3-knockout mice, sperm thiol assays and in-vitro fertilization.
- limitations
- This experiment-specific relationship does not establish a human dietary-deficiency threshold or supplementation benefit.
- organism
- Mouse
Selenium: literature corrections and mechanism additions · lines 976–985
Metabolic Ledger literature curation, 17 September 2026; primary papers linked individually · supports · Txnrd3-knockout mice, sperm thiol assays and in-vitro fertilization. · secondary_verified · secondary_verified
## txnrd3-sperm-thiol-control TXNRD3 helps manage protein sulfur bonds as sperm mature. Txnrd3 deletion in mice altered sperm protein thiol status, supporting a role for TXNRD3 in sperm redox remodeling. Experimental model: Txnrd3-knockout mice, sperm thiol assays and in-vitro fertilization. Organism: Mouse Limitations: This experiment-specific relationship does not establish a human dietary-deficiency threshold or supplementation benefit. Primary reference: [Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis](https://pmc.ncbi.nlm.nih.gov/articles/PMC9352919/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.